DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yin and SLC15A2

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_066568.3	Gene:	SLC15A2 / 6565	HGNCID:	10921	Length:	729	Species:	Homo sapiens

Alignment Length:	747	Identity:	296/747 - (39%)
Similarity:	438/747 - (58%)	Gaps:	98/747 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ETPPIP---------------YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNEETATVL 112
            |.||.|               ||.|:|||:.|||||||:||||:.:|:||....|.:||:|:|.:
Human    21 EVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSI 85

  Fly   113 FHTFTMLVYIFPLIGALIADGWLGKYKTILYLSLVYSLGAMVVSFGAVPLSG--MPTKAVTVVGL 175
            :|.|:.|.|..|::||.|||.||||:|||:||||||.||.::.|.||:|:.|  :....::::||
Human    86 YHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGL 150

  Fly   176 LLIAIGTGGIKPCVSAFGGDQFSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRADVHCFGD 240
            .|||:|||||||||:|||||||. ...:.:..::||:||.:|||||||||..||:||.||.|||
Human   151 SLIALGTGGIKPCVAAFGGDQFE-EKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFG- 213

  Fly   241 QDCFSLAFGVPAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRC----IADAFKGWQ----KRR 297
            :||::||||||.:||:.::::|..|.::|...||.||::..|.:|    |::.||...    ||:
Human   214 EDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQ 278

  Fly   298 HSEPMESFLDYAKPTVGSRMVQETKCLGRILRLFLPFPVFWALFDQQGSRWTFQATRMDGNVLGF 362
            |      :||:|......:::.:.|.|.|:|.|::|.|:||||.||||||||.||.||:.|:..|
Human   279 H------WLDWAAEKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFF 337

  Fly   363 QIKPDQMQVVNPLLILGFLPLFDYIIYPALARCGIR-RPLQKLTLGLLLAALGFFLSAGLEMKME 426
            .::||||||:||||:|.|:||||::||..:::|||. ..|:|:.:|::||.|.|.::|.:|:|:.
Human   338 VLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKIN 402

  Fly   427 QAAYRATPIEPDMTHLRIYNGMPCRYEI-------SSAVVQTPRVIEPLNVWEDLSLQMTESKEY 484
            :.| .|.| .|....|::.|......::       :|.::::.:..:....:..|.|: |:|:::
Human   403 EMA-PAQP-GPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLK-TKSQDF 464

  Fly   485 TFNAQPVSGECPSIIDKLRLQPGKSVSYFLAQDK----LVEFADGLQMAA---------TDTGRT 536
            .|:.:         ...|.|....||     |:|    ||...||..:::         |..|.|
Human   465 HFHLK---------YHNLSLYTEHSV-----QEKNWYSLVIREDGNSISSMMVKDTESRTTNGMT 515

  Fly   537 SVRALLNTPDGEGPVLLSTESATSQEPPL------TLDKGNVPQLHRITPGFARVDINGKKVASF 595
            :|| .:||...:..:.|||:::.:.....      |:.:|..|.:|..|.     |.|      |
Human   516 TVR-FVNTLHKDVNISLSTDTSLNVGEDYGVSAYRTVQRGEYPAVHCRTE-----DKN------F 568

  Fly   596 EAKEGRL-----YSILVTGSARDGYQHNVIEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFS 655
            ....|.|     |..::|.:...|.|...||.:..:.:||.|||||..::||.||||||||||||
Human   569 SLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFS 633

  Fly   656 YSQSPPSMKSVLQACWLLSVAIGNMLVVVIAEFKFTSSQSGEFTLFASLMLVDMMIFLWLARSYQ 720
            |||:|.||||||||.|||::|:||::|:|:|:|. ...|..||.||:.|:||..:||..:  .|.
Human   634 YSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFS-GLVQWAEFILFSCLLLVICLIFSIM--GYY 695

  Fly   721 YKD-QREDFEDDDDATIDSVMQSKPKATTVDT 751
            |.. :.||.....|..|..:..:..|..|..|
Human   696 YVPVKTEDMRGPADKHIPHIQGNMIKLETKKT 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	271/675 (40%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	132/269 (49%)
SLC15A2	NP_066568.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		4/12 (33%)
		2A1704	58..696	CDD:273343	272/677 (40%)
		PTR2	111..481	CDD:279226	157/389 (40%)
		Extracellular domain (ECD). /evidence=ECO:0000250\|UniProtKB:Q63424	402..611		50/237 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1253
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1353
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm8648
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.880