Protein Alignment yin and SLC15A1

DIOPT Version :10

• Sequence 1: NP_001284844.1
• Gene: yin / 31340
• FlyBaseID: FBgn0265575
• Length: 780
• Species: Drosophila melanogaster
• Sequence 2: NP_005064.1
• Gene: SLC15A1 / 6564
• HGNCID: 10920
• Length: 708
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 274/735 - (37%)
• Similarity: 419/735 - (57%)
• Gaps: 109/735 - (14%)

  Fly    69 YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNEETATVLFHTFTMLVYIFPLIGALIADG 133
            ||.|:.||:.|||||||:|||||.||:||.||.:.:::..:|.::|||..|.|:.|::||||||.
Human    12 YPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFVALCYLTPILGALIADS 76

  Fly   134 WLGKYKTILYLSLVYSLGAMVVSFGAV-----------PLSGMPTKAV-TVVGLLLIAIGTGGIK 186
            ||||:|||:.||:||::|..|.|..::           | ..:|...| :::||.|||:||||||
Human    77 WLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTP-DSLPVHVVLSLIGLALIALGTGGIK 140

  Fly   187 PCVSAFGGDQFSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRAD---VHCFGDQDCFSLAF 248
            |||||||||||. ..|..|..:|||:||.|||||||:||..||:||..   :|  ..|.|:.|||
Human   141 PCVSAFGGDQFE-EGQEKQRNRFFSIFYLAINAGSLLSTIITPMLRVQQCGIH--SKQACYPLAF 202

  Fly   249 GVPAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRCIADAFKG-WQKRRHSEP-MESFLDYAKP 311
            ||||.||..::|:|:.|..:|:...|.||::..|::||..|.|. ::.|..:.| .|.:||:||.
Human   203 GVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKE 267

  Fly   312 TVGSRMVQETKCLGRILRLFLPFPVFWALFDQQGSRWTFQATRMDGNVLGFQIKPDQMQVVNPLL 376
            ....|::.:.|.:.|::.|::|.|:|||||||||||||.|||.|.|.:...:|:|||||.||.:|
Human   268 KYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMSGKIGALEIQPDQMQTVNAIL 332

  Fly   377 ILGFLPLFDYIIYPALARCGIR-RPLQKLTLGLLLAALGFFLSAGLEMKMEQAAYRATPIEPDMT 440
            |:..:|:||.::||.:|:||.. ..|:|:.:|::||::.|.::|.::::::    :..|:.|...
Human   333 IVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEID----KTLPVFPKGN 393

  Fly   441 HLRIYNGMPCRYEISSAVVQTPRVIEPLNVWEDLSL--------QMTESKEY-TFNAQPVSGECP 496
            .::|                  :|:...|...::||        .|:::..: ||:
Human   394 EVQI------------------KVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFD--------- 431

  Fly   497 SIIDKL-RL---QPGKSVSYFLAQDK------LVEFA--------DGLQMAATDTGRTSVRAL-- 541
              ::|| |:   .||..|:......|      |:.:|        |||.. ..:.|...:|.:
Human   432 --VNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQ-KPEKGENGIRFVNT 493

  Fly   542 ---LNTPDGEGPV---LLSTESATSQEPP-----LTLDKGNVPQLHRITPGFARVDINGKKVASF 595
               |.|....|.|   :.|..::|.|..|     .|:....:|.  :..|.|          .:|
Human   494 FNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPP--QCQPNF----------NTF 546

  Fly   596 EAKEGRLYSILVTGSARDGYQHNVIEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFSYSQSP 660
            ..:.|..|:.:|........:..|.|.::.:||::..|:||..::|..||:||||||||||||:|
Human   547 YLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAP 611

  Fly   661 PSMKSVLQACWLLSVAIGNMLVVVIAEFKFTSSQSGEFTLFASLMLVDMMIFLWLARSYQYKDQR 725
            .:|||||||.|||:||:||::|:::|.....|.|..|:.|||:|:||..:||..:||.|.|.:..
Human   612 SNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPA 676

  Fly   726 E-DFEDDDDATIDSVMQSKP 744
            | :.:.|:|...:.:.:|.|
Human   677 EIEAQFDEDEKKNRLEKSNP 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	256/691 (37%)
SLC15A1	NP_005064.1	2A1704	28..670	CDD:273343	256/691 (37%)
		Extracellular domain (ECD). /evidence=ECO:0000250|UniProtKB:Q9JIP7	383..584		44/246 (18%)