DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yin and Slc15a3

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_075531.2	Gene:	Slc15a3 / 65221	MGIID:	1929691	Length:	578	Species:	Mus musculus

Alignment Length:	730	Identity:	145/730 - (19%)
Similarity:	256/730 - (35%)	Gaps:	271/730 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SVAFIISNEFCERFNYYGMRTILVLYLTNKLGYN-----EETATVLFHTFTMLVYIFPLIGALIA 131
            :.|.::..:..||..::|:.:.||||| |.|.:|     ...||:||...:   |:...:|..:|
Mouse    34 AAAAVLLVQMLERAAFFGVTSNLVLYL-NSLNFNWDGQQASRATLLFLGAS---YLLAPVGGWLA 94

  Fly   132 DGWLGKYKTI-----LYLSLVYSLGAMVVSFG---------------AVPLS------GMPTKAV 170
            |.:||::.||     |||:....|...:.:.|               |.|.|      ..|..|.
Mouse    95 DVYLGRFLTISLSLLLYLAASGLLLTTITNDGRRSFCGEMPELPLEPACPSSSCQGSWSSPYCAT 159

  Fly   171 TV-VGLLLIAIGTGGIKPCVSAFGGDQ-FSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRA 233
            |: :.|||:|:....::..:::||.|| ..|...:.:  :||:.||::||.|:::|......:..
Mouse   160 TLYLVLLLLALAASSVRSTLTSFGADQVMDLGRDATR--RFFNWFYWSINLGAILSLLVVAFIEQ 222

  Fly   234 DVHCFGDQDCFSLAFGVPAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRCIADAFKGWQKRRH 298
            ::       .|...:.:...|:..:..||:....::..:||.|:.   ||..:..||:.....|.
Mouse   223 NI-------SFLWGYSIIVGLVGLAFFIFLFATPVFITKPPTGSQ---VSSMLKLAFQNCCPCRR 277

  Fly   299 SEPMESFLDYAKPTVGSRM----VQETKCLGRILRLFLPFPV----FWALFDQQGSRWTFQAT-- 353
            |...:|...:..|...|..    .||.....::|...||..|    :|.::.|..|.:..|..
Mouse   278 SSSRDSESAHLLPDQRSNQPGPSPQEDMANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHL 342

  Fly   354 ------RMDGNV--------LGFQIKPDQMQVVNPLLILGFLPLFDYIIYPALARCG-IRRPLQK 403
                  |.:.|:        ..::|....:.:.|..:||..:|:.|::|.|.|.||. :...|||
Mouse   343 HIPNIFRTNPNISLLLRSDSSNYRIPEAWLLLANVAVILILIPVKDHLIDPLLLRCKLLPSSLQK 407

  Fly   404 LTLGLLLAALGFFLSAGLEMKMEQAAYRATPIEPDMTHLRIYNGMPCRYEISSAVVQTPRVIEPL 468
            :.||:.
Mouse   408 MALGMF----------------------------------------------------------- 413

  Fly   469 NVWEDLSLQMTESKEYTFNAQPVSGECPSIIDKLRLQPGKSVSYFLAQDKLVEFADGLQMAATDT 533
                           :.|.:..|:|    :::|.|||                     .:||..|
Mouse   414 ---------------FGFTSIIVAG----VLEKERLQ---------------------YIAANQT 438

  Fly   534 GRTSVRALLNTPDGEGPVLLSTESATSQEPPLTLDKGNVPQLHRITPGFARVDINGKKVASFEAK 598
                                                  ||||            .||
Mouse   439 --------------------------------------VPQL------------IGK-------- 445

  Fly   599 EGRLYSILVTGSARDGYQHNVIEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFSYSQSPPSM 663
                                  ::...:.:||.||:||.:::..:|:..|:.||||:||::|.||
Mouse   446 ----------------------DLYYAAPLSIWWQIPQYLLIGVSEIFASIPGLEFAYSEAPRSM 488

  Fly   664 KSVLQACWLLSVAIGNML---VVVIAEF----KFTSSQSGE---------FTLFASLMLVDMMIF 712
            :..:...:.....:|::|   :|.:..|    .:.....|.         |.|.|.:..|..::|
Mouse   489 QGAIMGIFFCLSGVGSLLGSGLVALLSFPGGWMYCPKDFGNINNCQMDRYFFLLAGIEAVTAVLF 553

  Fly   713 LWLARSYQYKDQRED 727
            ||:|.  :|:..|:|
Mouse   554 LWIAG--RYERTRQD 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	139/707 (20%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	69/312 (22%)
Slc15a3	NP_075531.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		PTR2	41..567	CDD:225646	144/723 (20%)
		MFS	179..515	CDD:304372	93/526 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..301		3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D365203at2759
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950