DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yin and Slc15a2

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_113860.2	Gene:	Slc15a2 / 60577	RGDID:	61972	Length:	740	Species:	Rattus norvegicus

Alignment Length:	748	Identity:	299/748 - (39%)
Similarity:	431/748 - (57%)	Gaps:	107/748 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PPIP------------YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNEETATVLFHTFT 117
            ||.|            ||.|:|||:.|||||||:||||:.:|.||....|.:||:|:|.::|.|:
  Rat    37 PPSPPKKSPPKIFGSSYPVSIAFIVVNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYHAFS 101

  Fly   118 MLVYIFPLIGALIADGWLGKYKTILYLSLVYSLGAMVVSFGAVPLSG--MPTKAVTVVGLLLIAI 180
            .|.|..|::||.|||.||||:|||:||||||.||.:..|.||:|:.|  |....:::|||.|||:
  Rat   102 SLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVFKSLGAIPILGGKMLHTILSLVGLSLIAL 166

  Fly   181 GTGGIKPCVSAFGGDQFSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRADVHCFGDQDCFS 245
            |||||||||:|||||||. ...:....::||:||.||||||||||..||:||.||.||| |||::
  Rat   167 GTGGIKPCVAAFGGDQFE-EEHAEARTRYFSVFYLAINAGSLISTFITPMLRGDVKCFG-QDCYA 229

  Fly   246 LAFGVPAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRCI----ADAFKG----WQKRRHSEPM 302
            ||||||.:||:.::::|..|.::||..||.||::..|.:||    .:.|:.    ..||:|
  Rat   230 LAFGVPGLLMVLALVVFAMGSKMYRKPPPEGNIVAQVIKCIWFALCNRFRNRSGDLPKRQH---- 290

  Fly   303 ESFLDYAKPTVGSRMVQETKCLGRILRLFLPFPVFWALFDQQGSRWTFQATRMDGNVLGFQIKPD 367
              :||:|.......::.:.|.|.|:|.|::|.|:||||.||||||||.||.:|:|::..|.::||
  Rat   291 --WLDWAAEKYPKHLIADVKALTRVLFLYIPLPMFWALLDQQGSRWTLQANKMNGDLGFFVLQPD 353

  Fly   368 QMQVVNPLLILGFLPLFDYIIYPALARCGIR-RPLQKLTLGLLLAALGFFLSAGLEMKMEQAAYR 431
            ||||:||.|:|.|:||||.:||..:::|.|. ..|:|:.:|::||.|.|.::|.:|.|:
  Rat   354 QMQVLNPFLVLIFIPLFDLVIYRLISKCRINFSSLRKMAVGMILACLAFAVAALVETKI------ 412

  Fly   432 ATPIEPDMTHLRIYNGM----PCRYEI---------------------SSAVVQTPRVIEPLNVW 471
                          |||    |...||                     :|.:|::....:....:
  Rat   413 --------------NGMIHPQPASQEIFLQVLNLADGDVKVTVLGSRNNSLLVESVSSFQNTTHY 463

  Fly   472 EDLSLQMTESKEYTF----NAQPVSGECPSIIDK-----LRLQPGKSVSYFLAQDKLVEFADGLQ 527
            ..|.|: .:|::..|    |:..|..: .|:.:|     |..|.|:|:|..|.:|..::.|:|
  Rat   464 SKLHLE-AKSQDLHFHLKYNSLSVHND-HSVEEKNCYQLLIHQDGESISSMLVKDTGIKPANG-- 524

  Fly   528 MAATDTGRTSVRALLNTPDGEGPVLLSTESATSQEPPLTLDKGNVPQLHRITPGFARVDINGKKV 592
            |||.....|..:.|..:.|.:.|:.:..:...|..  .|:.:|..|.:|..|.         .||
  Rat   525 MAAIRFINTLHKDLNISLDTDAPLSVGKDYGVSAY--RTVLRGKYPAVHCETE---------DKV 578

  Fly   593 ASFEAKE---GRLYSILVTGSARDGYQHNVIEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEF 654
            .|.:..:   |..|..::|.....|.|....|.:.::.:||.|||||.|::||||||||||||||
  Rat   579 FSLDLGQLDFGTTYLFVITNITSQGLQAWKAEDIPVNKLSIAWQLPQYVLVTAAEVMFSVTGLEF 643

  Fly   655 SYSQSPPSMKSVLQACWLLSVAIGNMLVVVIAEFKFTSSQSGEFTLFASLMLVDMMIFLWLARSY 719
            ||||:|.||||||||.|||:||:||::|:|:|:|. ..:|..||.||:.|:||..:||..:|  |
  Rat   644 SYSQAPSSMKSVLQAAWLLTVAVGNIIVLVVAQFS-GLAQWAEFVLFSCLLLVVCLIFSVMA--Y 705

  Fly   720 QYKD-QREDFEDDDDATIDSVMQSKPKATTVDT 751
            .|.. :.||..:..|..|.:|..:.....|.:|
  Rat   706 YYVPLKSEDTREATDKQIPAVQGNMINLETKNT 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	275/681 (40%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	133/269 (49%)
Slc15a2	NP_113860.2	2A1704	69..707	CDD:273343	276/683 (40%)
Slc15a2	NP_113860.2	PTR2	122..441	CDD:279226	150/346 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	313	1.000	Domainoid score	I1257
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1279
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm9126
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880