DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yin and Slc15a2

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_067276.3	Gene:	Slc15a2 / 57738	MGIID:	1890457	Length:	740	Species:	Mus musculus

Alignment Length:	721	Identity:	284/721 - (39%)
Similarity:	416/721 - (57%)	Gaps:	130/721 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PPIP------------YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNEETATVLFHTFT 117
            ||.|            ||.|:|||:.|||||||:||||:.:|.||....|.:||:|:|.::|.|:
Mouse    37 PPSPPKKSTPKLFGSSYPLSIAFIVVNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYHAFS 101

  Fly   118 MLVYIFPLIGALIADGWLGKYKTILYLSLVYSLGAMVVSFGAVPLSG--MPTKAVTVVGLLLIAI 180
            .|.|..|::||.|||.||||:|||:||||||.||.:..|.||:|:.|  |....:::|||.|||:
Mouse   102 SLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVFKSLGAIPILGGKMLHTILSLVGLSLIAL 166

  Fly   181 GTGGIKPCVSAFGGDQFSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRADVHCFGDQDCFS 245
            |||||||||:|||||||. ...:....::||:||.:|||||||||..||:||.||.||| :||::
Mouse   167 GTGGIKPCVAAFGGDQFE-EEHAEARTRYFSVFYLSINAGSLISTFITPMLRGDVKCFG-EDCYA 229

  Fly   246 LAFGVPAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRCIADAFKGW-----QKRRHSEPM--- 302
            ||||:|.:||:.::::|..|.::||..||.||::..|::||      |     :.|..||.:
Mouse   230 LAFGIPGLLMVLALVVFAMGSKMYRKPPPEGNIVAQVTKCI------WFAICNRFRNRSEDIPKR 288

  Fly   303 ESFLDYAKPTVGSRMVQETKCLGRILRLFLPFPVFWALFDQQGSRWTFQATRMDGNVLGFQIKPD 367
            :.:||:|.......::.:.|.|.|||.|::|.|:||||.||||||||.||.:|||::..|.::||
Mouse   289 QHWLDWAAEKYPKHLIMDVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPD 353

  Fly   368 QMQVVNPLLILGFLPLFDYIIYPALARCGIR-RPLQKLTLGLLLAALGFFLSAGLEMKMEQAAYR 431
            ||||:||.|:|.|:||||.:||..:::||:. ..|:|:.:|::||.|.|.::|.:|:|:
Mouse   354 QMQVLNPFLVLVFIPLFDLVIYRLISKCGVNFSSLRKMAVGMILACLAFAVAALVEIKI------ 412

  Fly   432 ATPIEPDMTHLRIYNGM----PCRYEISSAVV---------------QTPRVIEPLNVWED---- 473
                          |||    |...||...|:               ..|.::|.::.:::
Mouse   413 --------------NGMIHPQPASQEIFLQVLNLADGEIEVTVQGNRNNPLLVESISSFQNTTHY 463

  Fly   474 --LSLQMTESKEYTF----NAQPVSGE-------CPSIIDKLRLQPGKSVSYFLAQDKLVEFADG 525
              |.|: |:|::..|    |...|..|       |..::..   :.|:|:|..|.:|..::.|:|
Mouse   464 SKLRLE-TKSQDLHFHLKYNNLSVHNEYSVEEKNCYQLVVH---ENGESLSSMLVKDTGIKPANG 524

  Fly   526 LQMAATDTGRTSVRALLNT--------PDGEGPVLLSTESATSQEPPLTLDKGNVPQLHRITP-- 580
            :         |::| .:||        .|...|:.:..:...|:.  .|:.:|..|.:|..|.
Mouse   525 M---------TAIR-FINTLHKDMNISLDANAPLSVGKDYGVSEY--RTVQRGKYPAVHCETEDN 577

  Fly   581 ----GFARVDINGKKVASFEAKEGRLYSILVTGSARDGYQHNVIEVVALSTVSILWQLPQIVVMT 641
                ...::|.            |..|..::|.....|.|....|.:..:.:||.|||||.|::|
Mouse   578 VFSLNLGQLDF------------GTTYLFVITNITNRGLQAWKAEDIPANKLSIAWQLPQYVLVT 630

  Fly   642 AAEVMFSVTGLEFSYSQSPPSMKSVLQACWLLSVAIGNMLVVVIAEFKFTSSQSGEFTLFASLML 706
            |||||||||||||||||:|.||||||||.|||:||:||::|:::|:|. ...|..||.||:.|:|
Mouse   631 AAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFS-GLVQWAEFVLFSCLLL 694

  Fly   707 VDMMIF 712
            |..:||
Mouse   695 VVCLIF 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	269/689 (39%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	133/269 (49%)
Slc15a2	NP_067276.3	2A1704	69..707	CDD:273343	269/689 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	320	1.000	Domainoid score	I1232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1296
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm8880
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880