DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yin and slc15a2

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001034917.1	Gene:	slc15a2 / 556684	ZFINID:	ZDB-GENE-030131-5866	Length:	719	Species:	Danio rerio

Alignment Length:	734	Identity:	297/734 - (40%)
Similarity:	428/734 - (58%)	Gaps:	99/734 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNEETATVLFHTFTMLVYIFPLIGALIADG 133
            ||.|:|||:.|||||||:||||:.:|.||..|.|.:::..:|.::|.|:.|.|..||:||||||.
Zfish    28 YPVSIAFIVVNEFCERFSYYGMKAVLTLYFMNYLHWDKNLSTAIYHAFSGLCYFTPLLGALIADS 92

  Fly   134 WLGKYKTILYLSLVYSLGAMVVSFGAVPLSGMPTK--AVTVVGLLLIAIGTGGIKPCVSAFGGDQ 196
            ||||:|||:|||:||.:|.:|.|.||:|..|..|.  |:::|||.|||:|||||||||:||||||
Zfish    93 WLGKFKTIIYLSIVYVIGHVVKSVGAIPDVGDSTVHIALSMVGLGLIALGTGGIKPCVAAFGGDQ 157

  Fly   197 FSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRADVHCFGDQDCFSLAFGVPAILMIFSVII 261
            |. .....:..||||:||.:|||||::||..|||||.||.|||. ||::|||||||.||:.::::
Zfish   158 FD-EDNIDERRKFFSIFYMSINAGSVLSTIITPILRGDVQCFGG-DCYALAFGVPAALMVIALVV 220

  Fly   262 FMAGKRLYRCQPPAGNMIFGVSRCIADAFKG-WQKRRHSEPMESFLDYAKPTVGSRMVQETKCLG 325
            |::|..||:..||.||::..|.:||..|... |...:.|.....:||:|:.....|::||.|.:.
Zfish   221 FISGSGLYKKSPPEGNVLVRVCKCIGFAISNRWTNSKKSPKRSHWLDWAEEKYSKRLIQEIKMVC 285

  Fly   326 RILRLFLPFPVFWALFDQQGSRWTFQATRMD---GNVLGFQIKPDQMQVVNPLLILGFLPLFDYI 387
            |:|.|::|.|:|||||||||||||.|||||:   |.  ||.|||||||::|.||||.|:|:||..
Zfish   286 RVLVLYIPLPMFWALFDQQGSRWTLQATRMNMDFGG--GFIIKPDQMQMLNALLILVFIPIFDMG 348

  Fly   388 IYPALARCGIR-RPLQKLTLGLLLAALGFFLSAGLEMKMEQAAYRATPIEPDMTHLRIYNGMPCR 451
            |||.:..|.|: .||:|:..|::||||.|..:..:|:.:.:......|.:..:  :::||.|.
Zfish   349 IYPLVGLCRIKLTPLKKMATGMILAALAFCAATAVEVYVIKTVVEPPPAKESL--VQVYNLMD-- 409

  Fly   452 YEISSAVVQTPR---VIEPLNVWED----LSLQMT---ESKEYTFNAQPVSGECP---------S 497
               |...||.|.   ..|||..:|:    .||.:|   :.:....:...|:.||.         |
Zfish   410 ---SDVTVQFPAHNVFSEPLKPYEEPSGYSSLPLTGESQLQNVVVSHNGVNYECRLTFTERMAYS 471

  Fly   498 IIDKLRLQPGKSVSYFLAQDKLVEFADGLQMAATDTGRTSVRALLNTPDGEGPVLLSTESATSQE 562
            ::.....|.|.||.. |.:|.:.:         ::||...:| .:||......|.:.||     |
Zfish   472 LLLHPPAQSGGSVCN-LVKDHITK---------SETGAAYIR-FINTHTENINVTVGTE-----E 520

  Fly   563 PPLTLDKG-----NVPQLHRITPGFARVDINGKKVASFEAKE----------GRLYSILVTGSAR 612
            ...:.:.|     :||          |.:.| |.|...::||          |..|:::::.:.
Zfish   521 VHASANYGISRNISVP----------RGEYN-KAVCVTDSKEYEINLGLLDFGAFYTVILSETG- 573

  Fly   613 DGYQHNV----IEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFSYSQSPPSMKSVLQACWLL 673
                :|:    :|.:..:.:.|.||:||.|.:||.|||||:|||||||||:|.||||||||.||:
Zfish   574 ----NNLAIKKMEDIQANNIHIGWQIPQYVFLTAGEVMFSITGLEFSYSQAPASMKSVLQAGWLM 634

  Fly   674 SVAIGNMLVVVIAEFKFTSSQSGEFTLFASLMLVDMMIFLWLARSYQY--KDQREDF--EDDDDA 734
            :||.||::|:::|| .....|..||.|||:|::...:||..:|..|.|  .||.:..  |:.|..
Zfish   635 TVAFGNVIVLIVAE-GAGMEQWVEFLLFAALLVAVSIIFSIMAYFYTYVDPDQLDKLFKEEGDGG 698

  Fly   735 TIDSVMQSK------PKAT 747
            .::|..:.:      ||.|
Zfish   699 KVESSKKDELSLGEIPKQT 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	275/678 (41%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	140/265 (53%)
slc15a2	NP_001034917.1	2A1704	44..679	CDD:273343	275/678 (41%)
		PTR2	97..416	CDD:279226	157/329 (48%)
		Extracellular domain (ECD). /evidence=ECO:0000250\|UniProtKB:Q63424	389..594		48/243 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	695..719		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1211
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm6421
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.880