DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yin and SLC15A3

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_057666.1	Gene:	SLC15A3 / 51296	HGNCID:	18068	Length:	581	Species:	Homo sapiens

Alignment Length:	729	Identity:	136/729 - (18%)
Similarity:	244/729 - (33%)	Gaps:	274/729 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 AFIISNEFCERFNYYGMRTILVLYLTNKLGYN--EETATVLFHTFTMLVYIFPLIGALIADGWLG 136
            |.::..|..||..::|:...||||| |...:|  .|.||.....|....|:...:|..:||.:||
Human    36 AAVLLVEMLERAAFFGVTANLVLYL-NSTNFNWTGEQATRAALVFLGASYLLAPVGGWLADVYLG 99

  Fly   137 KYKTI-----LYLSLVYSLGAMVVSFG---------------AVPLSGMPTKA-------VTVVG 174
            :|:.:     |||:....|.|.....|               |.|.:|.|..:       |...|
Human   100 RYRAVALSLLLYLAASGLLPATAFPDGRSSFCGEMPASPLGPACPSAGCPRSSPSPYCAPVLYAG 164

  Fly   175 LLLIAIGTGGIKPCVSAFGGDQ-FSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRADVHCF 238
            |||:.:....::..:::||.|| ..|...:.:  :||:.||::||.|:::|......::.::
Human   165 LLLLGLAASSVRSNLTSFGADQVMDLGRDATR--RFFNWFYWSINLGAVLSLLVVAFIQQNI--- 224

  Fly   239 GDQDCFSLAFGVPAILMIFSVIIFMAGKRLYRCQPPAGNMI-----FGVSRCIADAFKGWQKRRH 298
                .|.|.:.:|...:..:..||:....::..:||.|:.:     ..:..|....   ||  ||
Human   225 ----SFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQL---WQ--RH 280

  Fly   299 S----EPMESFLDYAKPTVGSRMVQET---KCLGRILRLFLPFPVFWALFDQQGSRWTFQ----- 351
            |    :......|...|..|:...::.   :.|.:||.:.:....:|.::.|..|.:..|
Human   281 SARDRQCARVLADERSPQPGASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLH 345

  Fly   352 --------------ATRMDGNVLGFQIKPDQMQVVNPLLILGFLPLFDYIIYPALARCG-IRRPL 401
                          |.|..|:  .:.|....:.:.|.:::|..:||.|.:|.|.|.||. :...|
Human   346 IPNIFPANPANISVALRAQGS--SYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSAL 408

  Fly   402 QKLTLGLLLAALGFFLSAGLEMKMEQAAYRATPIEPDMTHLRIYNGMPCRYEISSAVVQTPRVIE 466
            ||:.||:........::..|||              :..|...:|
Human   409 QKMALGMFFGFTSVIVAGVLEM--------------ERLHYIHHN-------------------- 439

  Fly   467 PLNVWEDLSLQMTESKEYTFNAQPVSGECPSIIDKLRLQPGKSVSYFLAQDKLVEFADGLQMAAT 531
                 |.:|.|:   .|..:||.|
Human   440 -----ETVSQQI---GEVLYNAAP----------------------------------------- 455

  Fly   532 DTGRTSVRALLNTPDGEGPVLLSTESATSQEPPLTLDKGNVPQLHRITPGFARVDINGKKVASFE 596

Human   456 ----------------------------------------------------------------- 455

  Fly   597 AKEGRLYSILVTGSARDGYQHNVIEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFSYSQSPP 661
                                           :||.||:||.:::..:|:..|:.||||:||::|.
Human   456 -------------------------------LSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPR 489

  Fly   662 SMKSVLQACWLLSVAIGNM----LVVVIA----------EFKFTSSQSGE--FTLFASLMLVDMM 710
            ||:..:...:.....:|::    ||.:::          :|...::...:  |.|.|.:..|..:
Human   490 SMQGAIMGIFFCLSGVGSLLGSSLVALLSLPGGWLHCPKDFGNINNCRMDLYFFLLAGIQAVTAL 554

  Fly   711 IFLWLARSYQYKDQ 724
            :|:|:|..|:...|
Human   555 LFVWIAGRYERASQ 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	130/711 (18%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	67/319 (21%)
SLC15A3	NP_057666.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
SLC15A3	NP_057666.1	MFS	175..520	CDD:304372	88/539 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D365203at2759
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950