DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yin and pept-2

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_502002.1	Gene:	pept-2 / 177973	WormBaseID:	WBGene00003876	Length:	785	Species:	Caenorhabditis elegans

Alignment Length:	797	Identity:	266/797 - (33%)
Similarity:	400/797 - (50%)	Gaps:	127/797 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 HIHFAEDDRNGFETPPIP---------YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNE 106
            |:|  :|.|.|......|         :||....|:.||.||||::||||.:|.||..|.|.:::
Worm     5 HLH--DDPRPGSPVDHQPTTWGGIIKKWPKQTFLIVGNELCERFSFYGMRAVLTLYFFNILNFSQ 67

  Fly   107 ETATVLFHTFTMLVYIFPLIGALIADGWLGKYKTILYLSLVYSLGAMVVSFGAVPLSGMP-TKAV 170
            ..:|||||.||::.|..||:|:::|||::||:.||.::|:.|:.|.::::|.::..||.. ...:
Worm    68 SFSTVLFHAFTVICYSSPLLGSILADGYIGKFWTIFFISIFYACGQILLAFSSIAPSGSSHHPLL 132

  Fly   171 TVVGLLLIAIGTGGIKPCVSAFGGDQFSLPAQ-SFQLAKFFSLFYFAINAGSLISTTFTPILRAD 234
            .::|||::.:|||||||||||||||||  ||. :..::.|||:|||:||||||||...||..|:
Worm   133 DLLGLLIVGLGTGGIKPCVSAFGGDQF--PAHYTRMISLFFSMFYFSINAGSLISMWLTPYFRS- 194

  Fly   235 VHCFGDQDCFSLAFGVPAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRCIADAFKGWQKRRHS 299
            :.|||...|:.||||:||||||.:.::||||...|:..||..|:||.|...|..|.:.......:
Worm   195 MSCFGHDSCYPLAFGIPAILMIVATLVFMAGSFWYKKVPPKENIIFKVIGTITTALRKKASSSST 259

  Fly   300 EPMESFLDYA------------KPTVGS----RMVQETKCLGRILRLFLPFPVFWALFDQQGSRW 348
            .....:|:|:            |...|:    |.:::.|.|.|::.:.:|.|:||||:|||||.|
Worm   260 HQRSHWLEYSLDGHDCALSTECKNLHGNCAQRRYIEDIKRLFRVIVMMIPVPMFWALYDQQGSTW 324

  Fly   349 TFQATRMDGNVLGFQIKPDQMQVVNPLLILGFLPLFDYIIYPALARCGIRRP-LQKLTLGLLLAA 412
            ..||..||..|.||:|.||||.|:|..|||.|:|:|..|:||.:.:.|.:.. |:|:..|.:|.|
Worm   325 VLQAVGMDAKVFGFEILPDQMGVLNAFLILFFIPIFQSIVYPTIEKLGFQMTMLRKMAGGGILTA 389

  Fly   413 LGFFLSAGLEMKMEQAAYRATPIEP--DMTHLRIYNGMP-CRYEI------------SSAVVQTP 462
            :.||:...:::.:..    ..|..|  :..||.|.|.:| |.:.:            .|.:....
Worm   390 VSFFVCGIVQLFVNP----TLPYIPMANEAHLTIINTIPSCDFNVLIDSREPFDLLRKSGIAPDD 450

  Fly   463 RVIEPLNVWEDLSLQMTESKEYTF-NAQPVSGECPSIIDKLRLQPGKSVSYFLAQDKLVEFADGL 526
            .|.:|::...|...|    ...|| |..|   .||....:..|.|..|....|:.:.....|...
Worm   451 SVRKPISFTGDDFFQ----PNITFDNLAP---NCPKFTAEPMLAPATSYVLTLSPNGWAYNAVRP 508

  Fly   527 QMAATDTGRTSVRALLNTPDGEGPVLLSTESATSQ------------EPPLTLDKGNVPQ----- 574
            :...:..|..|:...|..|..:.|..::.|.....            |..:..|..||..
Worm   509 EKPKSGKGELSMGLNLIVPCDKIPSNVTWEQCNGTEGYSGAIALCKVESDVITDNNNVCDPTAKG 573

  Fly   575 ----LHRITP----GFAR---VDINGKKVASFEAKEG--RLY----------------------- 603
                |....|    .|::   |...|:..:..|.|.|  ||:
Worm   574 KFYVLSNANPLDVHDFSKKSTVTAFGRTYSPIEMKPGTYRLFYTDDSRTHFTPLNLPPVQQDHMG 638

  Fly   604 -SILVTGSARDGYQHNVI----EVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFSYSQSPPSM 663
             ..|:|.|.|......|:    .:|:.:.||||||:||.|::||.||:||:|||||:|:::.|.:
Worm   639 GQYLITVSTRSKNDSEVLATTESLVSYNRVSILWQIPQYVILTAGEVLFSITGLEFAYTEASPQL 703

  Fly   664 KSVLQACWLLSVAIGNMLVVVIAEFKFTSSQSGEFTLFASLMLVDMMIFLWLA-RSYQYKDQRED 727
            |||:||.||.:.|||:::||||......|..:.:..:|..:||..:.:|:.|| ..|:|.|...:
Worm   704 KSVVQALWLFTTAIGDLIVVVIFMLNIFSDVAVQMFVFGGIMLFVIFVFILLAVFYYEYADYSNE 768

  Fly   728 FE--------DDDDATI 736
            .|        |||...|
Worm   769 SEVLTEKMIVDDDHTRI 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	244/727 (34%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	118/277 (43%)
pept-2	NP_502002.1	2A1704	46..759	CDD:273343	244/726 (34%)
		PTR2	99..494	CDD:279226	147/408 (36%)
		MFS	<666..721	CDD:304372	32/54 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I930
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	466	1.000	Inparanoid score	I851
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		otm14792
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	1	1.100	-	-	LDO	PTHR11654
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980