DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yin and Slc15a1

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_476462.2	Gene:	Slc15a1 / 117261	RGDID:	621736	Length:	710	Species:	Rattus norvegicus

Alignment Length:	713	Identity:	272/713 - (38%)
Similarity:	407/713 - (57%)	Gaps:	85/713 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNEETATVLFHTFTMLVYIFPLIGALIADG 133
            ||.|:.||:.|||||||:|||||.:||||..|.||::::.:|.::|||..|.|:.|::||||||.
  Rat    12 YPLSIFFIVVNEFCERFSYYGMRALLVLYFRNFLGWDDDLSTAIYHTFVALCYLTPILGALIADS 76

  Fly   134 WLGKYKTILYLSLVYSLGAMVVSFGAV------PLSGMPTK-----AVTVVGLLLIAIGTGGIKP 187
            ||||:|||:.||:||::|..|:|..::      ...|.|..     |::::||.|||:|||||||
  Rat    77 WLGKFKTIVSLSIVYTIGQAVISVSSINDLTDHDHDGSPNNLPLHVALSMIGLALIALGTGGIKP 141

  Fly   188 CVSAFGGDQFSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRAD---VHCFGDQDCFSLAFG 249
            ||||||||||. ..|..|..:|||:||.|||||||:||..|||||..   :|  ..|.|:.||||
  Rat   142 CVSAFGGDQFE-EGQEKQRNRFFSIFYLAINAGSLLSTIITPILRVQQCGIH--SQQACYPLAFG 203

  Fly   250 VPAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRCIADAFKG-WQKRRHSEP-MESFLDYAKPT 312
            |||.||..::|:|:.|..:|:...|.||::..|::||..|.|. ::.|..:.| .|.:||:||..
  Rat   204 VPAALMAVALIVFVLGSGMYKKFQPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEK 268

  Fly   313 VGSRMVQETKCLGRILRLFLPFPVFWALFDQQGSRWTFQATRMDGNVLGFQIKPDQMQVVNPLLI 377
            ...|::.:.|.:.:::.|::|.|:|||||||||||||.|||.|.|.:...:|:|||||.||.:||
  Rat   269 YDERLISQIKMVTKVMFLYIPLPMFWALFDQQGSRWTLQATTMTGKIGTIEIQPDQMQTVNAILI 333

  Fly   378 LGFLPLFDYIIYPALARCGIR-RPLQKLTLGLLLAALGFFLSAGLEMKMEQAAYRATPIEPDMTH 441
            :..:|:.|.::||.:|:||.. ..|:|:|:|:.||::.|.::|.::::::    :..|:.|....
  Rat   334 VIMVPIVDAVVYPLIAKCGFNFTSLKKMTVGMFLASMAFVVAAIVQVEID----KTLPVFPSGNQ 394

  Fly   442 LRI------YNGMPCRYEISSAVVQTPRVIEPLNVWEDLSLQMTESKEY-TFNAQPV------SG 493
            ::|      .|.|...:...:..|                .||:::..: ||:...:      |.
  Rat   395 VQIKVLNIGNNDMAVYFPGKNVTV----------------AQMSQTDTFMTFDVDQLTSINVSSP 443

  Fly   494 ECPSIIDKL-RLQPGKSVSYFLAQDKLVEFA-DGLQMAATDTGRTSVR--ALLN---TPDGEGPV 551
            ..|.:.... ..:||...:..:....|.... |||.. ..:.|...:|  :.||   |....|.|
  Rat   444 GSPGVTTVAHEFEPGHRHTLLVWGPNLYRVVKDGLNQ-KPEKGENGIRFVSTLNEMITIKMSGKV 507

  Fly   552 LLSTESATSQEPPLTLDKGNVPQLHRITPGFARVDINGKKVA-----SFEAKE---GRLYSILVT 608
            .   |:.||.         :.........|.....||..::|     .|::..   |..|:.::.
  Rat   508 Y---ENVTSH---------SASNYQFFPSGQKDYTINTTEIAPNCSSDFKSSNLDFGSAYTYVIR 560

  Fly   609 GSARDG-YQHNVIEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFSYSQSPPSMKSVLQACWL 672
            ..|.|| .:....|.:..:||::..|:||..::|..||:||||||||||||:|.:|||||||.||
  Rat   561 SRASDGCLEVKEFEDIPPNTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWL 625

  Fly   673 LSVAIGNMLVVVIAEFKFTSSQSGEFTLFASLMLVDMMIFLWLARSYQYKDQRE---DFEDDD 732
            |:|||||::|:::||......|..|:.|||||:||..:||..:||.|.|.:..|   .|::|:
  Rat   626 LTVAIGNIIVLIVAEAGHFDKQWAEYVLFASLLLVVCIIFAIMARFYTYINPAEIEAQFDEDE 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	256/679 (38%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	127/275 (46%)
Slc15a1	NP_476462.2	2A1704	28..672	CDD:273343	256/679 (38%)
		Extracellular domain (ECD). /evidence=ECO:0000250\|UniProtKB:Q9JIP7	383..586		41/235 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..710		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	313	1.000	Domainoid score	I1257
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1279
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm9126
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	1	1.100	-	-	LDO	PTHR11654
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980