DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yin and slc15a2

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	XP_004917672.2	Gene:	slc15a2 / 100493689	XenbaseID:	XB-GENE-486968	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	725	Identity:	279/725 - (38%)
Similarity:	434/725 - (59%)	Gaps:	62/725 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 TPPIP------YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNEETATVLFHTFTMLVYI 122
            |..:|      ||.|:.||:.|||||||:||||:.:|.||..|.|.::|..:|.::|.|:.|.|.
Frog    31 TKKVPKLCGTNYPLSIMFIVVNEFCERFSYYGMKAVLTLYFLNYLHWDENLSTTVYHAFSGLCYF 95

  Fly   123 FPLIGALIADGWLGKYKTILYLSLVYSLGAMVVSFGAVPLSGMPT--KAVTVVGLLLIAIGTGGI 185
            .|||||.|||.||||:.||.|||::|.:|.::.|.||:|..|...  .|::::||:.||.|||||
Frog    96 TPLIGAPIADAWLGKFNTIFYLSILYVIGHVIKSVGAIPTVGSTEVHVALSIIGLIAIAFGTGGI 160

  Fly   186 KPCVSAFGGDQFSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRADVHCFGDQDCFSLAFGV 250
            ||||:|||||||. ...:.:.:||||:||.:|||||||||..||:||.||.|||. ||::|||||
Frog   161 KPCVAAFGGDQFE-EEHAQERSKFFSIFYLSINAGSLISTFVTPVLRGDVKCFGG-DCYALAFGV 223

  Fly   251 PAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRCIADAFKG-WQKRRHSEP-MESFLDYAKPTV 313
            ||.||..::|:|:||..:|:..||.||::..|.|||..|.|. |:.|....| .|.:||:|:...
Frog   224 PAALMFVALIVFVAGSGMYKKYPPQGNILASVFRCIGFALKNRWRHRSKQYPKREHWLDWAEEKF 288

  Fly   314 GSRMVQETKCLGRILRLFLPFPVFWALFDQQGSRWTFQATRMDGNVLGFQIKPDQMQVVNPLLIL 378
            ..|::.|.|.:.::|.|::|.|:|||||||||||||.|||||:.:..||.::|||:|::||||||
Frog   289 QKRLITEVKMVTKVLFLYIPLPMFWALFDQQGSRWTLQATRMNSDFGGFVLQPDQIQILNPLLIL 353

  Fly   379 GFLPLFDYIIYPALARCGIR-RPLQKLTLGLLLAALGFFLSAGLEMKMEQAAYRATPI-EPDMTH 441
            ..:|:||..|||.:..|.|. :.:.|:.:|::||||.|.::..:|:|:.:.   ..|: :..:::
Frog   354 ILIPIFDLCIYPLVRCCKIDFKAIPKMAIGMILAALAFAVATVVEIKINET---LPPVPKAQVSY 415

  Fly   442 LRIYN--GMPCRYEISS-AVVQTP-----RVIEPLNVWEDLSLQMTESKEYTFNAQ----PVSGE 494
            |::.|  |.....:|.. .:::.|     ..::|    :.:.|::|.:.. .|:|:    .|:.:
Frog   416 LQVLNLAGGDVDVDIPGFEIIKQPSLYGANALDP----DYVKLELTTAHN-NFDAKLTVGAVTAD 475

  Fly   495 CPSIIDKLRLQPGKSVSYFLAQDKLVEFADGLQMAATD--TGRTSVRAL------LNTPDGEGPV 551
            ||     :.:|...|.|..:..|.|  ..|.::.:.|.  .|..:||.:      :|...||..|
Frog   476 CP-----IHIQEKSSYSLLVYGDNL--NCDLIEESQTKPANGLAAVRFINMLNRDINVTIGESTV 533

  Fly   552 LLSTESATSQEPPLTLDKGNVPQLHRITPGFARVDINGKKVASFEAKEGRLYSILVTGSARDGYQ 616
              |.:......|.:|:.:|.:...:........:|:.   :.:|    |..||:::.....|..:
Frog   534 --SAKGNNGVSPYITVKRGKITATYPAGAEQQELDLG---LLNF----GAAYSVILVRDLGDTIE 589

  Fly   617 HNVIEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFSYSQSPPSMKSVLQACWLLSVAIGNML 681
            ....|.|:.::..:.||:||.|:::|.|||||||||||||||:|.||||||||.||.::||||::
Frog   590 FKKTEDVSANSFHVAWQVPQYVLLSAGEVMFSVTGLEFSYSQAPISMKSVLQAGWLFTIAIGNVI 654

  Fly   682 VVVIAEFKFTSSQSGEFTLFASLMLVDMMIFLWLARSYQYKDQREDFEDDDDATIDSVMQSKPKA 746
            |:::|: ..:.:|..||.|||:|::...:||..:...| .....:|.:::::.....:.:.:|.|
Frog   655 VLIVAQ-AGSLAQWAEFILFAALLVAVCIIFSIMGYFY-VPANPDDLKEEEELEKKQLPEGEPSA 717

  Fly   747 TTVDTTARKT 756
            ..::  .|||
Frog   718 IPME--ERKT 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	259/659 (39%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	134/263 (51%)
slc15a2	XP_004917672.2	2A1704	58..691	CDD:273343	259/659 (39%)
slc15a2	XP_004917672.2	PTR2	111..426	CDD:279226	148/319 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1261
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1196
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm9543
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980