DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yin and slc15a1a

DIOPT Version :9

Sequence 1:	NP_001284844.1	Gene:	yin / 31340	FlyBaseID:	FBgn0265575	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	XP_021334489.1	Gene:	slc15a1a / 100004272	ZFINID:	ZDB-GENE-091204-9	Length:	717	Species:	Danio rerio

Alignment Length:	728	Identity:	271/728 - (37%)
Similarity:	398/728 - (54%)	Gaps:	93/728 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YPKSVAFIISNEFCERFNYYGMRTILVLYLTNKLGYNEETATVLFHTFTMLVYIFPLIGALIADG 133
            ||.|:.||:.|||||||:|||||.:||||....|.........::|.|..|.|:.|::||:|||.
Zfish    22 YPISIFFIVVNEFCERFSYYGMRAVLVLYFRYFLXXXXXXXXXIYHAFVALCYLTPILGAIIADS 86

  Fly   134 WLGKYKTILYLSLVYSLGAMVVSFGAV------PLSGMPTK-----AVTVVGLLLIAIGTGGIKP 187
            ||||:|||:|||:||::|.:|::...:      ...|.|..     |::::||:|||:|||||||
Zfish    87 WLGKFKTIIYLSIVYAVGQVVMAVSTIHDITDANRDGTPDNFTLHIALSMLGLVLIALGTGGIKP 151

  Fly   188 CVSAFGGDQFSLPAQSFQLAKFFSLFYFAINAGSLISTTFTPILRAD---VHCFGDQDCFSLAFG 249
            ||:|||||||. ..||.||..|||:||..||||||:||..||:|||.   :|.  .|.|:.||||
Zfish   152 CVAAFGGDQFQ-EHQSRQLNTFFSVFYLCINAGSLLSTLITPVLRAQECGIHT--QQQCYPLAFG 213

  Fly   250 VPAILMIFSVIIFMAGKRLYRCQPPAGNMIFGVSRCIADAFKGWQKRRHSEPM----ESFLDYAK 310
            |||.||:.|:::|:||..:|....|.||::..|.:||..|..  .:.||...:    |.::|:|:
Zfish   214 VPAALMVVSLVVFIAGSGMYTKTAPEGNIMGSVCKCIWFALN--NRFRHRSDIYPKREHWMDWAE 276

  Fly   311 PTVGSRMVQETKCLGRILRLFLPFPVFWALFDQQGSRWTFQATRMDGNVLGFQIKPDQMQVVNPL 375
            ......::.:.|.:.::|.|::|.|:||.||||:|||||.|||.|.|:..||.::|||||.|||:
Zfish   277 EKYDKLLIAQIKMVLKVLFLYIPLPMFWTLFDQKGSRWTLQATTMTGDFGGFVLQPDQMQTVNPI 341

  Fly   376 LILGFLPLFDYIIYPALARCGIR-RPLQKLTLGLLLAALGFFLSAGLEMKMEQAAYRATPIEPDM 439
            |||..:|:.|.||:|.:.:||:. .||:::|:|:|.||..|..:|.::|:::    :..|..|..
Zfish   342 LILTLVPIMDRIIFPLIKKCGLNFSPLKRMTVGMLFAATAFIAAALVQMEID----KTLPNFPSS 402

  Fly   440 --THLRIYNGMPCRYEISSAVVQTPRVIEPLNVWEDLSLQMTESKEY----------TFNAQPVS 492
              :.|::.|     ....|.:|..|.. |||     |......|.:|          .||..|..
Zfish   403 SESQLKVVN-----MHSESLIVTVPSQ-EPL-----LIGSFESSPDYITFDQQDIRLAFNTTPEI 456

  Fly   493 GECPSIIDKLR---LQPGKSVSYFLAQDKLVEFADGLQMAATDTGRTSVRALLNTPDGEGPVLLS 554
            .:..|:|...|   :.|.:....:|.:|         ..:....|:.:||.:    :|....|..
Zfish   457 NKDLSLIKGSRQTLIIPSEPAEMYLKED---------IKSKPKEGKNAVRFV----NGWTAYLNI 508

  Fly   555 TESATSQEPPLTLDKGNVPQLHR---ITPGFARVDINGKKVASFEAKEGRLYSILVTGS--ARDG 614
            |...:|.:|..|.:...|.|..|   :|.|....:.:.|  ..|    |..|:.|:...  :.|.
Zfish   509 TNLESSLQPSETSNYTLVSQGMRKFTLTDGIQSCEFSRK--FGF----GSSYTFLIPSDLFSTDC 567

  Fly   615 YQHNVIEVVALSTVSILWQLPQIVVMTAAEVMFSVTGLEFSYSQSPPSMKSVLQACWLLSVAIGN 679
            .....||.:..::|.:..|:||..::|..|||||||||:|||||:|.:|||||||.||.:.|:||
Zfish   568 ESIKEIEDMQPNSVHMALQIPQYFLITTGEVMFSVTGLQFSYSQAPKNMKSVLQAGWLCTNAVGN 632

  Fly   680 MLVVVIAEFKFTSSQSGEFTLFASLMLVDMMIFLWLARSYQYKDQRE-------DFEDDDDATID 737
            ::|:::||......|..|:.|||||::...:||..:|..|.|.|..|       ..|.|.|
Zfish   633 IIVLIVAELGKLPKQWAEYVLFASLLVAVSIIFSIMAYFYTYIDPAEIEAEILKQQETDPD---- 693

  Fly   738 SVMQSKPKATTVD 750
                .|.|..|::
Zfish   694 ----KKKKKETLE 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yin	NP_001284844.1	2A1704	85..719	CDD:273343	250/672 (37%)
yin	NP_001284844.1	MFS	138..>398	CDD:304372	126/277 (45%)
slc15a1a	XP_021334489.1	PTR2	38..672	CDD:333212	250/672 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1211
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm6421
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	1	1.100	-	-	O	PTHR11654
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980