Protein Alignment ec and usp54a

DIOPT Version :9

• Sequence 1: NP_001096877.1
• Gene: ec / 31339
• FlyBaseID: FBgn0000542
• Length: 1765
• Species: Drosophila melanogaster
• Sequence 2: NP_001314804.1
• Gene: usp54a / 563912
• ZFINID: ZDB-GENE-090828-2
• Length: 1497
• Species: Danio rerio
• Alignment Length: 1783
• Identity: 387/1783 - (21%)
• Similarity: 641/1783 - (35%)
• Gaps: 524/1783 - (29%)

  Fly   136 DRCINAVIE-LFQQLQTSSEPALCPEPLRRALASGPLAGRRFPLGCLGDAAECFELLLHRVHSHI 199
            |.||...:: :|.|.|.|||..|..:.||.|||......:||.||.:.|||||||.:|.|:|.||
Zfish    72 DSCIFCALKSIFAQFQFSSEKVLPSDALRCALAKTFQDEQRFQLGIMDDAAECFENILMRIHFHI 136

  Fly   200 SPD-DGDSCESSACIAHRRFAMRVIEQSVC-KCGANSEQLPFTQMVHYVSASALTSQKSLALQSH 262
            |.: ..|.|.:..||.|::|||.:.||.|| .|||:|:.|||.|||||:|.::|.:|....|:..
Zfish   137 SDETKEDICTAKHCIPHQKFAMTLFEQCVCSNCGASSDPLPFIQMVHYISTTSLCNQAVRMLECR 201

  Fly   263 QQLS---FGQLLRAAGNMGDIRDCPNTCGAKIGICRALLNRPEVVSIGIVWDSERPAADQVHAVL 324
            ::.:   ||:|||.|..:||:|:||..||.|:.|.|.|:|.||:::||:||||:.  :|....|:
Zfish   202 EKPTPDMFGELLRNASTVGDLRNCPGNCGEKLRIRRVLMNSPEIITIGLVWDSDH--SDLAEDVI 264

  Fly   325 KAVGTSLRLGDVFHQVSEPRWAQQTQHELVGIVSYYGKHYTTFFFHTKLKVWVYFDDANVKEVGP 389
            .::||.|||||:|::|:|.: |:|.:..|||:|.||||||:||||.||::.|:|||||:|||:||
Zfish   265 HSLGTVLRLGDLFYRVTEDK-AKQAELYLVGVVCYYGKHYSTFFFQTKIRKWIYFDDAHVKEIGP 328

  Fly   390 SWEGVVDKCSRGRYQPLLLLYAVPQQPTVGNGVGIGHVDVAMPASAPSIAGSVVRRAVT------ 448
            .|:.||.:|.:|.|||||||||.|:               ..|.||..:|..:.....|
Zfish   329 KWKDVVSRCIKGHYQPLLLLYADPR---------------GTPVSAQDLASRLDLHHYTKAYYDS 378

  Fly   449 -PSPEKPSLGNTRRAITPTPLRTPPNDYQNLSVIQKNIFPSNLAMGT------DETDAYISRKTV 506
             .|..:||:.:..|..:.|...:..:.:.:...:..:.  |:.:.||      :::.::.|.:|
Zfish   379 EDSGREPSISSDTRTDSSTDSYSYKHSHSHHESMASHF--SSDSQGTVICNPDNDSASHSSLET- 440

  Fly   507 EHVLSAQYQNLSVIQDKIGGGNGVGVGQQSVDKDGGFLSRK--------------------PIEA 551
                :....:...:|......:||      :|:..|.|.||                    ..:.
Zfish   441 ----TGPLTDSDTVQRHTLRKDGV------LDRKAGVLDRKRSASRPRKFEARGDSRNRVSKTDE 495

  Fly   552 VLSA------QLARRQHLQLQRSHSAESSSG-----------------HASSNGSSPPSDGLTMP 593
            ||||      :..:.|  |:.||....|||.                 .|||:||..|.|...
Zfish   496 VLSAGYHSEGETLKEQ--QVPRSLPKPSSSRLRDFKETMSNIIHNRPLSASSSGSVCPPDSTI-- 556

  Fly   594 EHLNQPRRRDSGNWSGDRNSASSASSTTLDNPYLYMVAKRGVAAVPQSPTRHGLPYD-------- 650
                  :.||   |..|..|:.|.||::           .|....|..|.|..|..|
Zfish   557 ------KVRD---WEADSTSSESKSSSS-----------GGRYRPPWKPRREALNIDSIFSRERR 601

  Fly   651 --PGYDSF-SLSSTDSYPPKHALNPQ---LAKIPEAAMGVVPNGGAMPHGHGNGQLALSGDCEKL 709
              .||... :|.|.|:.|....::.:   ...||    |.:..|...|              .:|
Zfish   602 KQAGYSPLGALLSEDTGPQVGLMSTKQITFQDIP----GPLRRGSEQP--------------PRL 648

  Fly   710 CHEADQLLEKSRLVEESH---DLETALVLCNAAAGRARAAM--DAPYSNPHTMTFARMKHNTCVM 769
            ....:...|.|.....|.   |:..:....|........||  ..|..||...|..:.|.::.::
Zfish   649 IQRMESGYESSERNSNSPVSLDMPVSEATTNGMHSLQEGAMIKPPPDVNPSWKTVTKSKSSSALL 713

  Fly   770 R------ARSLHRRILVEKGAETEAMPELKHMREGSTSSVKHVRQNSKDRTLEKEQQQL------ 822
            :      ..|.|..:..|..:|.:.:.|         ...:..|:....|..|||::..
Zfish   714 QDVKASVKGSSHTSLAGEGRSELDELQE---------EVARRAREQELQRRKEKEKEAAMGFNPR 769

  Fly   823 --QFQQIQQIQQ----------IHQIQQQIPASIEIYATLPKRKSPLKALASASACDD--NAIEY 873
              :|..:.::|.          :.:.:..:..|:.:       :...:..|:.|..::  :.:.:
Zfish   770 PSKFMDLDELQNQGKGEGFERCVLEAESLLDQSLRL-------EQAGEVAAALSVVNEAMSKLRH 827

  Fly   874 EQEKQLATSPGKPE---RESRSLFGRKDKEKEKRSRSEDRNKLTREFSLTETLLVNAKDTLKKHK 935
            ...:..|.:.|:.:   |.:|.|..|. ::|::....|.:..|:.:....:.||.|.|
Zfish   828 TLHESSANAQGRMQKCMRRARGLQQRM-QQKQQEEEKEQKQPLSEQSVPVQILLTNVK------- 884

  Fly   936 EDKDEKKEKDKSGKKQHKIRRKLLMGGLIRRKNRSMPDLTEAVDDSTANAGITHHPHYPAQGVTT 1000
             ::|||...:.:.:....:.        |:.::.|.| ::|           |..|..|:....|
Zfish   885 -EEDEKAISEDALRPPSPLH--------IKPQSTSKP-ISE-----------TPGPPVPSYHTDT 928

  Fly  1001 AGTLLGTSVDDSAVGLGKHGHGMSGYISEGHFDYSGSGSASNSGAGSNPNPNLE----RSKLMRK 1061
            ......|....|::.:.::..|....:                   .|.|..::    ||.....
Zfish   929 CSQKDNTGDHPSSLDVTENDRGPRDLV-------------------INTNSLVQTASKRSPATVP 974

  Fly  1062 SFHGSGRQLTMVPKVAPPPPMRTSSTLTPQQQQQQQQQFHHEANLSNLSAMSSNTSISE--DSCQ 1124
            ....:|.:.::...|:...|...|:.|||....      |.|..|.|.....|...:|:  .:||
Zfish   975 VIAANGCEASLQSSVSLNTPAYFSARLTPSTTD------HSEEGLQNPHRPQSLHGLSQAPHACQ 1033

  Fly  1125 TIITTCAQ---VHSEQSPLKDLQMLVAQDELPLPPPMELPPYPSPPHSS---CHSRQASEDFPPP 1183
            ..:...::   ..|.:.|  |.:.......:..|..:..|..|.||..|   ...|.|.     |
Zfish  1034 KSLPVPSRNWSCRSLERP--DSRPTTLDSSMYSPVDLSSPSSPCPPFLSSPVLEQRPAG-----P 1091

  Fly  1184 PPPELDLEPLNQQLSQLQALEAASKQQRQQLESLEGTTSILAQLQQRQHLLKLRKEQANHPGAAT 1248
            .|.|...|.:|:..:..:...:......::|..|
Zfish  1092 MPVERWAENVNRYYNSQKCARSGRDSPCEELSEL------------------------------- 1125

  Fly  1249 TDATWLKELQAKQANDLRAMQRKLEASSPSSVRDLTHRFEQTSIRSYASQELLSQPGQSQQLGQL 1313
             |:.:...|:|.      ::.|....:||    .|.:|......|.:::       |.|..||:.
Zfish  1126 -DSLYQASLKAP------SIPRATRGTSP----QLANRSGPAVSRKHST-------GSSATLGRS 1172

  Fly  1314 RTQMNGLPNGNAKMDVDEVDAMPAVRNSLPAALSAHQLLPKPKYEMTQSQIAEEIREV--ELLNT 1376
            :|     |....:................|.:.:|:.   :|..| .:|..||.:|.:  .|..|
Zfish  1173 KT-----PTAEIERSAYRTPTYSTKPLQKPVSAAAYN---EPLGE-DESYSAENLRRIARSLSGT 1228

  Fly  1377 MVQQTLNQNGAAALPKRVKKKSVSFCDQVILVATAGNEEDDDFIPNPILERVLRTAQHPN----- 1436
            :|      .|...:|     .|.||                    :|   .|.|.::|.|
Zfish  1229 VV------GGRTDVP-----PSRSF--------------------DP---HVSRMSKHVNVQLPT 1259

  Fly  1437 --EKVTAQMIQQQQQNMMRLQTEAQPRQQQVQQLQQPSPM----------LGRPAGATADMQRYV 1489
              ...:..::.....|......|..|  |.:....:|.|:          |..|.|.|.|.|:..
Zfish  1260 HRSSTSLHVLPLPSHNPPMFPHEPPP--QHLHSSHRPHPVPTSSHLHQQTLRPPHGQTGDCQKTN 1322

  Fly  1490 QRMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQELYRQQQLHRTSMSGIASQQHLQQLD 1554
            :.:....:                              .|.:.::..|..::|
Zfish  1323 KFLAVLDR------------------------------GEAFSRENYHNVALS------------ 1345

  Fly  1555 AQYTTMPR----------PLHHSQLGS---------YSVTLQKHQQLQQQQQQQQQQQAPQQLSL 1600
              |.|:||          |::..:.||         |:...:.|           :..||.:...
Zfish  1346 --YGTLPRAPRRSVSSGPPVYQMRPGSLPRNHPDAAYATLSRPH-----------RTTAPSRTMD 1397

  Fly  1601 GYFSNGSVATSEQVPLPSPYQRVPLPHGYQPAAAGPYYPLPNAQQHLQQQQLMAKPVQKKVSFEP 1665
            |::         :.|...|....|:||              ::.:|....:...:|::..|..|.
Zfish  1398 GFY---------RQPHQHPSLTAPIPH--------------HSSRHHPHTEPPTQPLRLDVPPER 1439

  Fly  1666 GTKGEADCLPPPPPPPQKNGLPETGSAGSGHPGAAPGASGAGGTTSAGITAIPTRVYNNAIVKAS 1730
            ..:...|....|...|:       |....|||                       ||
Zfish  1440 DWRAARDTHVFPRTDPR-------GGTSRGHP-----------------------VY-------- 1466

  Fly  1731 AKAVECNLCRKRHVIAPAVYCTNCEYYL 1758
                .|.||::........||..|..::
Zfish  1467 ----ICGLCKQNPAEPTRSYCQACRAHM 1490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ec	NP_001096877.1	Peptidase_C19	183..410	CDD:239072	119/231 (52%)
usp54a	NP_001314804.1	UCH	32..330	CDD:306860	127/260 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1707
eggNOG	1	0.900	-	-		E1_KOG1887
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002086
OrthoInspector	1	1.000	-	-		otm25235
orthoMCL	1	0.900	-	-		OOG6_104646
Panther	1	1.100	-	-	O	PTHR22975
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5015
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.890