Protein Alignment ec and USP53

DIOPT Version :9

• Sequence 1: NP_001096877.1
• Gene: ec / 31339
• FlyBaseID: FBgn0000542
• Length: 1765
• Species: Drosophila melanogaster
• Sequence 2: NP_001358324.1
• Gene: USP53 / 54532
• HGNCID: 29255
• Length: 1073
• Species: Homo sapiens
• Alignment Length: 1264
• Identity: 317/1264 - (25%)
• Similarity: 481/1264 - (38%)
• Gaps: 344/1264 - (27%)

  Fly   125 GHINSAGNSERDRCINAVIE-LFQQLQTSSEPALCPEPLRRALASGPLAGRRFPLGCLGDAAECF 188
            ||:     .:.|.||...:: :|.|.|.|.|.||..:.:|.|||......:||.||.:.||||||
Human    65 GHV-----CQGDACIFCALKTIFAQFQHSREKALPSDNIRHALAESFKDEQRFQLGLMDDAAECF 124

  Fly   189 ELLLHRVHSHISPD-DGDSCESSACIAHRRFAMRVIEQSVCK-CGANSEQLPFTQMVHYVSASAL 251
            |.:|.|:|.||.|. |.|.|.|.:||.|::|||.:.||.||: |||:|:.||||:.|.|:|.:||
Human   125 ENMLERIHFHIVPSRDADMCTSKSCITHQKFAMTLYEQCVCRSCGASSDPLPFTEFVRYISTTAL 189

  Fly   252 TSQKSLALQSHQQLS---FGQLLRAAGNMGDIRDCPNTCGAKIGICRALLNRPEVVSIGIVWDSE 313
            .::....|:.|::..   |.:||:||....|.|.||:.||.||.|.|.|:|.||:|:||:|||||
Human   190 CNEVERMLERHERFKPEMFAELLQAANTTDDYRKCPSNCGQKIKIRRVLMNCPEIVTIGLVWDSE 254

  Fly   314 RPAADQVHAVLKAVGTSLRLGDVFHQVSEPRWAQQTQHELVGIVSYYGKHYTTFFFHTKLKVWVY 378
            .  :|...||::.:.|.|.|..:|::|::.. |:.::..|||::.|..:||..|.||||...||:
Human   255 H--SDLTEAVVRNLATHLYLPGLFYRVTDEN-AKNSELNLVGMICYTSQHYCAFAFHTKSSKWVF 316

  Fly   379 FDDANVKEVGPSWEGVVDKCSRGRYQPLLLLYAVPQQPTVGNGVGIGHVDVAMPASAPSIAGSVV 443
            ||||||||:|..|:.||.||.|..:|||||.||.|      :|..:...|......:.|...||
Human   317 FDDANVKEIGTRWKDVVSKCIRCHFQPLLLFYANP------DGTAVSTEDALRQVISWSHYKSV- 374

  Fly   444 RRAVTPSPEKPSLGNTRRAITPTPLRTPPNDYQNLSVIQKNIFPSNLA---MGTDETDAYISR-- 503
              |.....|||.:..:.. :............:|......||..||.:   .|..:..|.:|.
Human   375 --AENMGCEKPVIHKSDN-LKENGFGDQAKQRENQKFPTDNISSSNRSHSHTGVGKGPAKLSHID 436

  Fly   504 --------------KTVE--HVLSAQYQNLSVIQDKIGGGNGVGVGQQSVDKD-GGFLSRKPIEA 551
                          |.:|  ::||:|.::|...|.|     .:|..:..||:| ..|.|..|
Human   437 QREKIKDISRECALKAIEQKNLLSSQRKDLEKGQRK-----DLGRHRDLVDEDLSHFQSGSP--- 493

  Fly   552 VLSAQLARRQHLQLQRSHSAESSS---------GHASSN-GSSPPSDGLTMPEHLNQPRRRDSGN 606
              .|....:||......||....|         ..||:. .||..|..|...|.:....:.|:|.
Human   494 --PAPNGFKQHGNPHLYHSQGKGSYKHDRVVPQSRASAQIISSSKSQILAPGEKITGKVKSDNGT 556

  Fly   607 W--------SGDRNSASSASSTTLDNPYLYMVAKRGVAAV-PQSPTR-HGLPYDPGYDSFSLSST 661
            .        |.||.::..:||.:.:..:..|.....|.:: .:|..| |...:.|...:...||.
Human   557 GYDTDSSQDSRDRGNSCDSSSKSRNRGWKPMRETLNVDSIFSESEKRQHSPRHKPNISNKPKSSK 621

  Fly   662 D----SYPPKHALNPQLAKIPEAAMGVVPNGGAMPHGHGNGQLALSGDCEKLCHEADQLLEKSRL 722
            |    ::|.::.....|..|.|..|.......:....:|.|.....|..|...|..:..::::..
Human   622 DPSFSNWPKENPKQKGLMTIYEDEMKQEIGSRSSLESNGKGAEKNKGLVEGKVHGDNWQMQRTES 686

  Fly   723 VEESHDLETALVLCNAAAGRARAAMDAPY--SNPHTMTFARMKHNTCV---MRARSLHRRILVEK 782
            ..||.|     .:.|.:..     :|:|.  .|...|..:.:|...|.   :...:|::    |:
Human   687 GYESSD-----HISNGSTN-----LDSPVIDGNGTVMDISGVKETVCFSDQITTSNLNK----ER 737

  Fly   783 GAETEAMPELKHMREGSTSSVKHVRQNSKDRTLEKEQQQLQFQQIQQIQQIHQIQQQIPASIEIY 847
            |..|..  :.:|..||....::::....|......| ..||.:.       |.|
Human   738 GDCTSL--QSQHHLEGFRKELRNLEAGYKSHEFHPE-SHLQIKN-------HLI----------- 781

  Fly   848 ATLPKRKSPLKALASASACDDNAIEYEQEKQLATSPGKPERESRSLFGRKDKEKEKRSR-SEDRN 911
                                                                   |||. .||..
Human   782 -------------------------------------------------------KRSHVHEDNG 791

  Fly   912 KLTREFSLTETLLVNAKDTLKKHKEDKDEKKEKDKSGKKQHKIRRKLLMGGLIRRKNRSMPDLTE 976
            ||....||......||::.:.:..|.|.||..:.|                           .:|
Human   792 KLFPSSSLQIPKDHNAREHIHQSDEQKLEKPNECK---------------------------FSE 829

  Fly   977 AVD-DSTANAGITHHPHYPAQGVTTAGTLLGTSVDDSAVGLGKHGHGMSGYISEGHFDYSGSGSA 1040
            .:: :::...|:..|                  ||:||                       ||..
Human   830 WLNIENSERTGLPFH------------------VDNSA-----------------------SGKR 853

  Fly  1041 SNSGAGSNPNPNLERSKLMRKSFHGSGRQLTMVPKVAPPPPMRTSSTLTPQQQQQQQQQFHHEAN 1105
            .|    ||...:|..|.|         |.:.:.|:.||           ..|||....|.:.|.:
Human   854 VN----SNEPSSLWSSHL---------RTVGLKPETAP-----------LIQQQNIMDQCYFENS 894

  Fly  1106 LSNLSAMSSNTSISEDSCQTIITTCAQVHSEQSPLKDLQMLVAQDELPLPPPMELPP----YPSP 1166
            ||....:.|  :...|.||                  :..|..|:   ||||  |||    ..|.
Human   895 LSTECIIRS--ASRSDGCQ------------------MPKLFCQN---LPPP--LPPKKYAITSV 934

  Fly  1167 PHSSCHSRQASEDFPPPPPPELDLEPLNQQLSQL--QALEAASKQQRQQLESLEGTTSILAQLQQ 1229
            |.|     :.||.     .|::.|..:.:..|.|  .:|..||:      .|||.:|.:  ..::
Human   935 PQS-----EKSES-----TPDVKLTEVFKATSHLPKHSLSTASE------PSLEVSTHM--NDER 981

  Fly  1230 RQHLLKLRKEQANHPGAATTDATWLKELQAKQANDLRAMQRKLEA----------SSPSSVRDLT 1284
            .:...::|:...|.|...::.:|          ||.:|....::|          :.|:....||
Human   982 HKETFQVRECFGNTPNCPSSSST----------NDFQANSGAIDAFCQPELDSISTCPNETVSLT 1036

  Fly  1285 HRFEQTSIRS------YASQELLSQPGQS 1307
            ..|...|..:      |..:..||.|..|
Human  1037 TYFSVDSCMTDTYRLKYHQRPKLSFPESS 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ec	NP_001096877.1	Peptidase_C19	183..410	CDD:239072	111/231 (48%)
USP53	NP_001358324.1	UCH	31..348	CDD:395355	131/290 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..437		8/45 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..636		33/155 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1764
eggNOG	1	0.900	-	-		E1_KOG1887
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6196
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002086
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22975
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.820