DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ec and Usp54

DIOPT Version :9

Sequence 1:	NP_001096877.1	Gene:	ec / 31339	FlyBaseID:	FBgn0000542	Length:	1765	Species:	Drosophila melanogaster
Sequence 2:	XP_038949489.1	Gene:	Usp54 / 408223	RGDID:	1303206	Length:	1650	Species:	Rattus norvegicus

Alignment Length:	1876	Identity:	438/1876 - (23%)
Similarity:	681/1876 - (36%)	Gaps:	596/1876 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 SVSALAKVASSVELAVMGYNSTGNGNSNGHINSA----------GNSER---------DRCINAV 142
            ||..:....||:.:|.....|...|.::..:|||          ..|.|         |.||...
  Rat    14 SVQGMFAPRSSMSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTSHKCMGDSCIFCA 78

  Fly   143 IE-LFQQLQTSSEPALCPEPLRRALASGPLAGRRFPLGCLGDAAECFELLLHRVHSHISPD-DGD 205
            :: :|:|.|.|||..|..:.||.|||......:||.||.:.|||||||.||.|:|.||:.: ..|
  Rat    79 LKGIFKQFQCSSEKVLPSDTLRSALAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKED 143

  Fly   206 SCESSACIAHRRFAMRVIEQSVC-KCGANSEQLPFTQMVHYVSASALTSQKSLALQSHQQLS--- 266
            .|.:..||:|::|||.:.||.|| .|||.|:.|||.|||||:|.::|.:|....|:..::.|
  Rat   144 ICTAPHCISHQKFAMTLFEQCVCTSCGATSDPLPFIQMVHYISTTSLCNQAICMLEKREKPSPGM 208

  Fly   267 FGQLLRAAGNMGDIRDCPNTCGAKIGICRALLNRPEVVSIGIVWDSERPAADQVHAVLKAVGTSL 331
            ||:||:.|..|||:||||:.||.:|.|.|.|:|.|::::||:||||:.  :|....|:.::||.|
  Rat   209 FGELLQNASTMGDLRDCPSNCGERIRIRRVLMNAPQIITIGLVWDSDH--SDLAEDVIHSLGTCL 271

  Fly   332 RLGDVFHQVSEPRWAQQTQHELVGIVSYYGKHYTTFFFHTKLKVWVYFDDANVKEVGPSWEGVVD 396
            :|||:|.:|::.| |:|::..|||::.||||||:||||.||::.|:|||||:|||:||.|:.||.
  Rat   272 KLGDLFFRVTDDR-AKQSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVVT 335

  Fly   397 KCSRGRYQPLLLLYAVPQQPTVGNGVGIGHVDVAMPASAPSIAGSVVRRAVTPSPEKPSLGNTRR 461
            ||.:|.|||||||||.||      |..:...|  :|..|..::.:........|..:||:.:..|
  Rat   336 KCIKGHYQPLLLLYADPQ------GTPVSAQD--LPPHAQLLSHTKTCYDSEDSGREPSISSDTR 392

  Fly   462 AITPTPLRTPPNDYQNLSVIQK-----------NIFPSNLAMGTDE----TDAYISRK--TVEHV 509
            ..:.|. ..|.....:.||:..           |:...:::..:.:    ||:..::|  |.:..
  Rat   393 TDSSTE-SYPYKQSHHESVVSHFSSDSQGTVIYNVENDSMSQSSRDTGHLTDSECNQKHTTKKGP 456

  Fly   510 LSAQYQNLSVIQDKIGGGNGVGV-----------GQQSVDKDGGFLSRKPIEAVLSAQLARRQHL 563
            |..:.:....|:.|.......|.           ..::..|.......|..:..:|..:..|..|
  Rat   457 LVERRRGSGRIRRKADAPQASGYHSEGETLKEKQAPRNASKSSSTSRLKDFKETVSNMIHSRPSL 521

  Fly   564 QLQ---------------------------RSHSAESSSGHASSNGSS-------PPSDGL---- 590
            ..|                           |....||:|..|.|:.||       |..:.|
  Rat   522 ASQTNAASPCVGRAGDQPDKIPARNLPLHSRGWETESTSSEARSSSSSKYRPTWRPKRESLNIDS 586

  Fly   591 ----------------TMPE--------------------------------------HL--NQP 599
                            |.||                                      ||  ..|
  Rat   587 IFSKDKRKHCGYTQLKTFPEDAAKEFAQDEVSNPVANDIKDGGPSSQHKLWGTARPGSHLLEQHP 651

  Fly   600 R---RRDSGNWSGDRNSASSASSTTLD-------NPYLYMVAKRGVAAVPQSPTRHGLPYDPGYD 654
            |   |.:||..|.:|||:|..|   ||       |.|.....||.|..||.  .||    .|...
  Rat   652 RLIQRMESGYESSERNSSSPVS---LDAAPPECLNVYRDQSTKRAVGFVPS--WRH----IPKSH 707

  Fly   655 SFSLSSTDSYPP---------------------------------KHALNPQLAKIPEAAMGVVP 686
            |.|:...||..|                                 :..|..:..|..|||.|..|
  Rat   708 SSSILEVDSTAPVTGWTETQPFSDGEITSKSELDELQEEVARRAQEQELRKKREKELEAAKGFNP 772

  Fly   687 NGGAMPHGH------GNGQLALSG---DCEKLCHEADQLLEKSRLVEESHDLETALVLCNAAAGR 742
            :    |..:      .|..|||||   ..|:...||:.:.|:|..:|:..|...||.|||.|..:
  Rat   773 H----PSRYMDLDELQNQVLALSGRSDGFERSLQEANSVFEESLHLEQEGDCAAALALCNEAISK 833

  Fly   743 ARAAMDAPYSNPHTMTFARMKHNTCVMRARSLHRRILVEKGAETEAMPELKHMREGSTSSVKHVR 807
            .|..:....|:.|:......|....:.:||||..|:..:..::....|......:|.........
  Rat   834 LRLTLHDASSSTHSRALVDKKLQISIRKARSLQDRMQQQPPSQQPVQPSASLPSQGGGLPQPTSE 898

  Fly   808 QNSKDRTLEKEQQQLQFQQIQQIQQIHQIQQQIPA-SIEIYATLPKRKSPL------KALASASA 865
            |:...:.|..:|.||:                 |. ..|:.||.|...||.      .:|.|.|.
  Rat   899 QSVPLQVLLSQQTQLE-----------------PCKDSELGATSPFFHSPASCPEPHSSLVSPSP 946

  Fly   866 CDDNAIEYEQEKQLATSPGKPERE------SRSLFGRKDKEKEKRSRSEDRNKLTREFSLTETLL 924
                |....|.....||..|..:.      :.|.|.|:|..|     :..|.::.   |..|.|.
  Rat   947 ----AQSVSQHSPPGTSALKLLKSFEVDIVNHSAFHRQDLPK-----ATGRTEMN---SQHECLP 999

  Fly   925 VNA-KDTLKKHKEDKDEKKEKDKSGKKQHKIRRKLLMGGLIRRKNRSMPDLTEAVDDSTANAGIT 988
            .:| :|.|:.|:||                                              |:..:
  Rat  1000 FDALEDRLQGHRED----------------------------------------------NSCCS 1018

  Fly   989 HHPHYPAQG-VTTAGTLL---GTSVDDSAVGLGKHGHGMSGYISEGHFDYSGSGSASNSGAGSNP 1049
            ..|  |.:| .||...||   .|.||.|.        ||.       :.:|..|:.|.....|..
  Rat  1019 KFP--PQEGRDTTQDQLLEGRKTPVDISM--------GMP-------WSHSAGGATSERVMHSLN 1066

  Fly  1050 NPNLERSKLMRKSFHGSGRQLTMVPKVAPPPPMRTSST-----LTPQQQQQQQQQFHHEANLSNL 1109
            :|:            ....|..:.|..|..|.|..:::     ..|.|:..|           :|
  Rat  1067 SPS------------SPSAQPAVPPYGACHPIMSAAASPVLHAADPMQKLNQ-----------HL 1108

  Fly  1110 SAMSSNTSI-------SED-------SCQTIITTCAQVHSEQSPLKDLQMLVAQD-ELP------ 1153
            .|.|..||:       ||:       |.:.::.:.|:...:........::.:|| .||
  Rat  1109 QAQSLQTSLASKVVRGSEEPYRPEFPSTKGLVRSLAEQFQKIRNTSTRDVIGSQDRSLPNGLRKS 1173

  Fly  1154 -LPPPMELPPYPSPPHSSCHSRQASEDFPPPPPPELDLEPLNQQL---------SQLQALEAASK 1208
             .|....||....|....|  |..::   ||.|...:.:|..::.         |.|...||:.:
  Rat  1174 SSPSDFMLPLSQGPEKEHC--RWVNQ---PPSPDGRERQPCWEEPAGHPSVSIDSGLPNGEASRR 1233

  Fly  1209 QQRQQLE---------------------SLEGTTSILAQLQQRQHLLKLRKEQANH--PGAATTD 1250
            :|.:..|                     |:...||:  .|....::.:|...|..|  ||.....
  Rat  1234 RQPRLAEADIYQGKLPQVTDTRPTELGSSVSLGTSL--PLDSWVNVTRLCDSQVKHRAPGLGVKS 1296

  Fly  1251 AT--------------------WLKELQAKQANDLRAM-QRKLEASSPSSVRDLTHRFEQTSIRS 1294
            ::                    |.::.: ::.::|.:: |..|:|||            .|....
  Rat  1297 SSHDSRTCVTYPERNPILLHPHWNQDTE-QETSELESLYQASLQASS------------HTGYSD 1348

  Fly  1295 YASQELLSQPGQSQQLGQLRTQMNGLPNGNAKMDVDEVDAMPAVRNSLPAALSAHQLLPKPKYEM 1359
            :.||::..||          ..:.|..:|..:                       :|...|..::
  Rat  1349 WRSQDVAWQP----------LSLTGSADGMGR-----------------------RLHSAPGLDL 1380

  Fly  1360 TQSQIAEEIREVELLNTMVQQTLNQNGAAALPKRVKKKSVSFCDQVILVATAGNEEDDDFIPNPI 1424
            :::..||..|.:...:|:   .::|:.:     .|:||:
  Rat  1381 SKTPTAEMERILYEPSTV---PVSQDSS-----NVRKKT-------------------------- 1411

  Fly  1425 LERVLRTAQHPNEKVTAQMIQQQQQNMMRLQTEAQPRQQQV--QQLQQPSPMLGRP---AGATAD 1484
                |.|..|.:...:..:|....  :..|..:..|.|.|.  ..:..|| |.|.|   .|.:..
  Rat  1412 ----LETGHHCSSSSSLPVIHDPP--VFLLDPKLYPPQPQFLSPDVLMPS-MAGEPYRSPGTSRS 1469

  Fly  1485 MQRYVQRMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQELYRQQQLHRTSMS---GIAS 1546
            :|:::....:.:..|..:...:....:....:.                    ||..|   |..:
  Rat  1470 VQQFLAMCDRDETPQGVKYTGRTLNYRSLPHRS--------------------RTDASWGPGTET 1514

  Fly  1547 QQHLQQLDAQYTTMP--RPLHHSQLGSYSVTL-QKHQQLQQQQQQQ-------------QQQQAP 1595
            .||   :.|:..|.|  :|    || :|:.|| ::||.||....|.             ....:|
  Rat  1515 NQH---IGARVLTAPACKP----QL-TYTATLPERHQGLQVPHAQSWGNLFHLPSHPSAVHPGSP 1571

  Fly  1596 QQLSL-----GYFSNGSVATSEQVPLPSPYQRVPLPHGYQPAAAGPYYPLPNAQQH 1646
            ...||     ..:::|||..|.   .|.| :|:.:|    |...|.....|:..:|
  Rat  1572 PSSSLHVLHRSSWNSGSVLGSR---TPGP-RRIDVP----PDDDGRQSQYPSQYRH 1619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ec	NP_001096877.1	Peptidase_C19	183..410	CDD:239072	119/231 (52%)
Usp54	XP_038949489.1	UCH	32..349	CDD:395355	145/319 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1635
eggNOG	1	0.900	-	-		E1_KOG1887
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002086
OrthoInspector	1	1.000	-	-		otm46083
orthoMCL	1	0.900	-	-		OOG6_104646
Panther	1	1.100	-	-	O	PTHR22975
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.900