DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ec and AgaP_AGAP000205

DIOPT Version :9

Sequence 1:	NP_001096877.1	Gene:	ec / 31339	FlyBaseID:	FBgn0000542	Length:	1765	Species:	Drosophila melanogaster
Sequence 2:	XP_003436937.1	Gene:	AgaP_AGAP000205 / 1272059	VectorBaseID:	AGAP000205	Length:	2197	Species:	Anopheles gambiae

Alignment Length:	2355	Identity:	1016/2355 - (43%)
Similarity:	1185/2355 - (50%)	Gaps:	764/2355 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIKFRYKRKEPTNVVGVAAPTAGAA--ALGSGASSTPGT--SPTSPVSVPVPVQAHHPHPQLGHL 61
            |||||||||:|     |.|.||...  |:.|.| ||.|:  :.||..||..|...|:
Mosquito     1 MIKFRYKRKDP-----VPAATAKKVDDAVDSRA-STNGSQQAATSSPSVQQPQPVHY-------- 51

  Fly    62 ISNNGGTLPRS--SPRKLIL------------DGADKS----------ATLTRQQSKQKSVSALA 102
              ::..|||:.  ||...:.            ||.|:.          .:..:||.:|:::....
Mosquito    52 --SSSATLPKDHRSPSATVCLSGDAQQHPDRRDGNDEPGRFNGHPGGWGSYQQQQQQQQAIQYHQ 114

  Fly   103 KVASSVELAVMGYNSTGNGNSNGHINSAGNSERDRCINAVIELFQQLQTSSEPALCPEPLRRALA 167
            ::...|:|.          |....:......|...||:||:|||.||||||||||||||||||||
Mosquito   115 ELLQRVKLE----------NELHQLQQQQRYEYLSCIDAVVELFSQLQTSSEPALCPEPLRRALA 169

  Fly   168 SGPLAGRRFPLGCLGDAAECFELLLHRVHSHISPDDGDSCESSACIAHRRFAMRVIEQSVCKCGA 232
            |||||||||||||||||||||||||||||.|:||.|.||||::.|:||:||||||:|||||:|||
Mosquito   170 SGPLAGRRFPLGCLGDAAECFELLLHRVHQHLSPVDSDSCEAAQCVAHQRFAMRVVEQSVCECGA 234

  Fly   233 NSEQLPFTQMVHYVSASALTSQKSLALQSHQQLSFGQLLRAAGNMGDIRDCPNTCGAKIGICRAL 297
            |||:||||||||||||||||||.||::|..|.::||||||.|||||||||||:.|||||||.|||
Mosquito   235 NSEKLPFTQMVHYVSASALTSQNSLSIQHQQNITFGQLLRNAGNMGDIRDCPSACGAKIGIRRAL 299

  Fly   298 LNRPEVVSIGIVWDSERPAADQVHAVLKAVGTSLRLGDVFHQVSEPRWAQQTQHELVGIVSYYGK 362
            ||||:|||||:|||||||.||||||||||:||:|||.|||.|||:.||||...|||||:||||||
Mosquito   300 LNRPDVVSIGVVWDSERPPADQVHAVLKAIGTTLRLCDVFQQVSDHRWAQTVHHELVGVVSYYGK 364

  Fly   363 HYTTFFFHTKLKVWVYFDDANVKEVGPSWEGVVDKCSRGRYQPLLLLYAVPQ----QPTVGNGVG 423
            |||||||||||:|||||||||||||||||||||:|||||||||||||||:||    |........
Mosquito   365 HYTTFFFHTKLRVWVYFDDANVKEVGPSWEGVVEKCSRGRYQPLLLLYALPQPQQLQQQQQQQQQ 429

  Fly   424 IGHVDVAMPASAPSIAGSVVRRAVTPSPEKPSLG-NTRRAITPTPLRT-PPNDYQNLSVIQKNIF 486
            :......:...|..      ||||||||||.|:| |.||||||||.|. |..|||||:|||..||
Mosquito   430 LQQHQQELTTLAQH------RRAVTPSPEKASMGSNVRRAITPTPNRALPICDYQNLTVIQSKIF 488

  Fly   487 ----------PSNLAMGTD--ETDAYISRKTVEHVLSAQYQNLSVIQDKIGGGNGVGVGQQSVDK 539
                      |:|.|.|.|  ..:.|||||.|::||||||||||||||||
Mosquito   489 ASANGSSTSGPANTAAGEDGEGKEHYISRKAVQNVLSAQYQNLSVIQDKI--------------- 538

  Fly   540 DGGFLSRKPIEAVLSAQLARRQHLQLQRSH--------------------------------SAE 572
               |.|...::   ..|..::||.|.|:..                                |..
Mosquito   539 ---FPSAHDLQ---QQQQQQQQHQQQQQQQQQLRVLANGPTKQQQQLGYNGVPPNSVGMPNVSPS 597

  Fly   573 SSSGHASSNGSSPPSDGLTMPEHLNQPRRRDSGNWSGDRNSASSASSTTLDNPYLYMVAKRGV-A 636
            ||||.|||      .|||:||:||||||||||||||||||||||:|||||||||||:|.||.| .
Mosquito   598 SSSGTASS------PDGLSMPDHLNQPRRRDSGNWSGDRNSASSSSSTTLDNPYLYLVGKRQVGG 656

  Fly   637 AVPQSPTR------------HGLP--YDPGYDSFSLSSTDSYPPKHALNPQLAKIPEAAMGVVPN 687
            :||.||||            ||..  ||.||||:|||||||:|.||.        |...     .
Mosquito   657 SVPASPTRANNSAGAAGLGTHGAAQFYDAGYDSYSLSSTDSFPSKHQ--------PSGG-----G 708

  Fly   688 GGAMPHGHG------------NGQLALSGDCEKLCHEADQLLEKSRLVEESHDLETALVLCNAAA 740
            |||.|...|            ...:.|||||||||.|||||||||||:|::||||||||||:|||
Mosquito   709 GGAGPSAAGLLLSAAGAAVKIPDSVVLSGDCEKLCMEADQLLEKSRLLEDAHDLETALVLCHAAA 773

  Fly   741 GRARAAMDAPYSNPHTMTFARMKHNTCVMRARSLHRRILVEKGAETEAMPELKHMREGSTSSVKH 805
            .:||||||||||||||||||||||||||||||||:||||:|||.|
Mosquito   774 SKARAAMDAPYSNPHTMTFARMKHNTCVMRARSLNRRILIEKGGE-------------------- 818

  Fly   806 VRQNSKDRTLEKEQQ-QLQFQQIQQIQQIH-------QIQQQI---------------------- 840
                     :.|||| |.|.||.||.||:|       |.|||.
Mosquito   819 ---------MIKEQQLQQQLQQQQQQQQLHLHHQTMQQQQQQYHVLTSGGALQHRRQNSKEKLLA 874

  Fly   841 ----------------------------------PA-SIEIYATLPKRKSPLKALASASACDDNA 870
                                              |: ||||||||||:|..||.:.:.....:.|
Mosquito   875 AGGGHHHPHHHALAGSTTAGTTAGAGTSNTASASPSKSIEIYATLPKKKVTLKLIEAEHVEPEPA 939

  Fly   871 IEYEQEKQLATSP-GKPERESRSLFGR-----KDKE----KEKRSRSEDRNKLTREFSLTETLLV 925
            ::.   |..|..| |..||||||||.|     .||:    :|||||||||||     :|.:..||
Mosquito   940 VDL---KAAAGGPAGGSERESRSLFARVTSSSSDKDGKEGREKRSRSEDRNK-----ALADPGLV 996

  Fly   926 NAKDTLKKHKEDKD--EKKEKD-KSGKKQHKIRRKLLMGGLIRRKNRSMPDLTEAVD-------- 979
            ||||||:||||:||  |:|||: |||||||||||||||||||||||||||||||||.
Mosquito   997 NAKDTLRKHKEEKDANERKEKEAKSGKKQHKIRRKLLMGGLIRRKNRSMPDLTEAVGSGGPGCDP 1061

  Fly   980 --------DSTANAGITHHPHYPAQGVTTAGTLLGTSVDDSAVGL--GKHGHGMSGYISEGHFDY 1034
                    :....||        ..|....|.|.|.|:|||||||  ....:..|||:|||||||
Mosquito  1062 AGKGADLLEGKGGAG--------GAGGPAGGALHGASLDDSAVGLSVSAKDNANSGYLSEGHFDY 1118

  Fly  1035 SGSGSASNSGAGSNPNPNLERSKLMRKSFHGSGRQLTMVPKVAPPPPMRTSSTLTP--------- 1090
            ...         ||.|||||||||||||||||||.|: ||||.||||:|..|.|:.
Mosquito  1119 HPI---------SNTNPNLERSKLMRKSFHGSGRSLS-VPKVPPPPPVRIGSALSAVSSGTAGAS 1173

  Fly  1091 -----QQQQQQQQQFH------------------------------------------------- 1101
                 ||..|||||.|
Mosquito  1174 QQQHHQQHHQQQQQQHQPNGAPYGSSSSASSSPSMLQMQKLPLNGVNLRHLEYVTEAAAAAHPPS 1238

  Fly  1102 -----HEANLSNLSAMSSNTSISEDSCQTIITTCAQVHSEQSPLKDLQMLVAQDELPLPPP---- 1157
                 ||||:||||.||||||:|||||||||||||.||.||||.|       ..:||.|||
Mosquito  1239 GIKPFHEANVSNLSTMSSNTSMSEDSCQTIITTCAVVHQEQSPAK-------PQDLPPPPPTEEV 1296

  Fly  1158 --------------------MELPPYPSPPHSSCHSRQASEDFPPPPPPELDLEPLNQQLSQLQA 1202
                                :|||||||||.::|||||||||| |||||.:|.|||::|||::|:
Mosquito  1297 DSIVRYQQQQQQQQQVPQQQLELPPYPSPPSTTCHSRQASEDF-PPPPPAIDFEPLHEQLSEIQS 1360

  Fly  1203 LEAASKQQRQQL-----------ESLEGTTSILAQLQQRQHLLKLRKEQ--------------AN 1242
            |:....|.:..:           ..::.|||||||||.:|...:|:::|              .|
Mosquito  1361 LQTTGGQGKPPMMMMMMSHSSGQTGIQNTTSILAQLQAKQLQQQLQQQQQQQQQYQQHQEQHNLN 1425

  Fly  1243 HP-------GAATTDATWLKELQAKQANDLRAMQR-------------------KLEASSPS--- 1278
            :|       ...|....||||||.||. .|:..|:                   ||.|..|:
Mosquito  1426 NPISTSEILNETTRSEIWLKELQLKQL-ALKQQQQCREVSPAQQQYQPQQQQGPKLPAGPPATGG 1489

  Fly  1279 ---SVRDLTHRFEQTSIRSYASQELLSQPGQSQQLGQLRTQMNGLPNGNAKMDVDEVDAMPAVRN 1340
               |||||..||||  |:....|:|.||  .:.....:||.|:||...:.:...:.....|....
Mosquito  1490 DQRSVRDLASRFEQ--IKLSVGQQLQSQ--SAAHPPNVRTGMSGLLLADQQQKANARSTPPPPPP 1550

  Fly  1341 SLPAALSA----------------------------HQLLPKPKYEMTQSQIAEEIREVELLNTM 1377
            ..|||..|                            ...||||:|::.||||.|||||||:||.:
Mosquito  1551 PQPAATDAPDTVPSADFSTGSGEDVVDCPRDIGMVYRMQLPKPRYDIAQSQIQEEIREVEMLNQV 1615

  Fly  1378 VQQTLNQNGAAA-------------LPK--RVKKKSVSFCDQVILVATAGNEEDDDFIPNPILER 1427
            |||||| |||||             ||.  |.|||||||||||||||||..:|||.|||||||||
Mosquito  1616 VQQTLN-NGAAAAAAAAAAASKSDVLPAAGRTKKKSVSFCDQVILVATADEDEDDGFIPNPILER 1679

  Fly  1428 VLRTA----QHPNEKVTAQMIQQQQQNMM----------------------RLQT---------- 1456
            |||||    ..|.....|..:.....::.                      ||.|
Mosquito  1680 VLRTAGGGGGGPTAAAAAAAVGCTDADVTPGVLLPAGNGGESVAPAAGLPERLPTLSTSITYHPI 1744

  Fly  1457 EAQPRQQQVQQLQQPSPMLGRPA-GATADMQRYVQRMQQQQQQQQQQ------------QQQQQQ 1508
            :|....||::  |||:|. |.|. ...|||.:....:|:|.||||||            :..:||
Mosquito  1745 KAPSPTQQLK--QQPTPP-GAPVYSLAADMHKQNLEIQRQLQQQQQQYYGAVNNSSPELESYKQQ 1806

  Fly  1509 QQQQQQQQQ-----------------------------------QQQQQQQQQHQELYRQQQLHR 1538
            ||||||...                                   |.|||||||.|.||.......
Mosquito  1807 QQQQQQYSSIPANATIFKTHQFSAAMPTTKATPSLYGVPPNMSLQLQQQQQQQQQRLYGSDTGSE 1871

  Fly  1539 TSMSGIASQQHLQQLDAQYTTMPR-----------PLHHSQLGSYS------------------- 1573
            .|..|..|... .||.:.|.|:|.           |..|: :|.|.
Mosquito  1872 LSFDGRNSSSS-SQLTSPYMTVPHLLGDGGAGSGPPPQHA-VGGYQTVSASPTTITTNTSPASNT 1934

  Fly  1574 ------VTLQKHQQL--------------------------------QQQQ-----QQQQQQQAP 1595
                  .||.:||||                                ||||     ..||||...
Mosquito  1935 LLRQNIATLLQHQQLGGVTPATMRPTPPNGHTLPNVYQKPPKPLNAYQQQQPTTTTTPQQQQHQL 1999

  Fly  1596 QQLSLGYFSNGSVATS---EQVPLPSPYQRVPLPHGYQPAAAGPYYPLPN-------AQQHL--- 1647
            |||:.....||.|.|.   .|....|||||||||.||.    ..|:..|:       .||.|
Mosquito  2000 QQLTSAAGYNGGVTTMPSYTQQQSSSPYQRVPLPLGYD----NLYHEQPSMGLMTQQQQQQLLGL 2060

  Fly  1648 ------QQQQLMAKPVQKKVSFEPGTKGEADCLPPPPPPPQKNGLPETGSAGSGHPGAAPGASGA 1706
                  ||||...||:||||||||||||               |.|: ||.|: :...:|.|:|.
Mosquito  2061 GNSVAQQQQQQQTKPIQKKVSFEPGTKG---------------GGPD-GSPGT-NVSPSPSANGC 2108

  Fly  1707 --------------------GGTTSAGITAIPTRV------YNN--AIVKASAKAVECNLCRKRH 1743
                                .......:..:||||      |.|  ||||.|||||:||||||:|
Mosquito  2109 QPQQQQQQQHYQLQLQDAQQQQQQQQNVVGLPTRVVPIATTYGNGSAIVKPSAKAVQCNLCRKKH 2173

  Fly  1744 VIAPAVYCTNCEYYL 1758
            .|.||:||::||.||
Mosquito  2174 CILPAIYCSDCETYL 2188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ec	NP_001096877.1	Peptidase_C19	183..410	CDD:239072	187/226 (83%)
AgaP_AGAP000205	XP_003436937.1	Peptidase_C19	185..412	CDD:239072	187/226 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	837	1.000	Domainoid score	I250
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H89215
Inparanoid	1	1.050	1329	1.000	Inparanoid score	I481
OMA	1	1.010	-	-		QHG25993
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002086
OrthoInspector	1	1.000	-	-		oto110398
Panther	1	1.100	-	-	LDO	PTHR22975
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X15475
TreeFam	0	0.000	Not matched by this tool.
	10	10.070