DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ec and usp54

DIOPT Version :9

Sequence 1:	NP_001096877.1	Gene:	ec / 31339	FlyBaseID:	FBgn0000542	Length:	1765	Species:	Drosophila melanogaster
Sequence 2:	XP_004915986.1	Gene:	usp54 / 100497431	XenbaseID:	XB-GENE-940633	Length:	1724	Species:	Xenopus tropicalis

Alignment Length:	1891	Identity:	434/1891 - (22%)
Similarity:	650/1891 - (34%)	Gaps:	637/1891 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 YNSTGNGN---------------SNGHINSAGNSE-----------------------------R 135
            |.:||.|.               |.|.||..|.:.                             .
Frog     8 YFATGRGGVQEMFTPRNSISIAPSKGLINEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMG 72

  Fly   136 DRCINAVIE-LFQQLQTSSEPALCPEPLRRALASGPLAGRRFPLGCLGDAAECFELLLHRVHSHI 199
            |.||...:: :|.|.|.|||..|..:.||.|||......:||.||.:.|||||||.||.|:|.||
Frog    73 DSCIFCALKGIFNQFQCSSEKVLPSDTLRCALAKTFQDEQRFQLGIMDDAAECFENLLIRLHIHI 137

  Fly   200 SPDD-GDSCESSACIAHRRFAMRVIEQSVC-KCGANSEQLPFTQMVHYVSASALTSQKSLALQSH 262
            :.:. .|.|.:..||:|::|||.:.||.|| .|||.|:.|||.|||||:|.:||.:|....|:..
Frog   138 ADESKEDICTAQHCISHQKFAMTLFEQCVCTSCGATSDPLPFIQMVHYISTTALCNQAIFMLERK 202

  Fly   263 QQLS---FGQLLRAAGNMGDIRDCPNTCGAKIGICRALLNRPEVVSIGIVWDSERPAADQVHAVL 324
            ::.:   ||:||:.|..|||:|:||:.||.||.|.|.|:|.|::::||:||||:.  :|....|:
Frog   203 EKPTPDMFGELLQKASTMGDLRNCPSNCGEKIRIRRVLMNAPQIITIGLVWDSDH--SDLAEDVI 265

  Fly   325 KAVGTSLRLGDVFHQVSEPRWAQQTQHELVGIVSYYGKHYTTFFFHTKLKVWVYFDDANVKEVGP 389
            .::||.|:|||:|::|::.| .:.::..|||::.||||||:||||.||::.|:|||||:|||:||
Frog   266 HSLGTCLKLGDLFYRVTDDR-GKHSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGP 329

  Fly   390 SWEGVVDKCSRGRYQPLLLLYAVPQQPTVGNGVGIGHVDVAMPASAPSIAGSVVRRAVT------ 448
            .|:.||.||.:|.|||||||||.|:               ..|.:.|.:...:..|..|
Frog   330 KWKDVVTKCIKGHYQPLLLLYADPR---------------GTPVTVPDVLSQMDLRQYTRTCYDS 379

  Fly   449 -PSPEKPSLGNTRRAITPTPLRTPPNDYQNL---SVIQKNIFPSNLAMGTD----ETDA------ 499
             .|..:||:.:..|    |...|....|::.   ||:.   :.|:.:.||.    |.||
Frog   380 EDSGREPSISSDTR----TDSSTDSYHYKHSHHESVVS---YFSSESQGTVIYNLENDAASQSSR 437

  Fly   500 -------------YISRK----------------------------------------------- 504
                         :.|||
Frog   438 DTGHLTDSECSQRHFSRKGPFTDRKRSSSRPRRKGDESQSSGYHSEGETLKEKQAPRTGLKLSSS 502

  Fly   505 ---------TVEHVLSAQYQNLSVIQDKIGGGNGVG----------------------VGQQSVD 538
                     ||.:::..:....|  |....|.:.||                      :...:.:
Frog   503 SSRLRDFKATVSNIIHNRPSQAS--QTSSQGFHHVGSNLDQSEIKPPTNLSMRLRDWDIDNSNNE 565

  Fly   539 KDGGFLSR-----KPIEAVLSAQLARRQHLQLQRSHS-----AESSSGHASSN-----GSSPPSD 588
            ...||.:|     :|....|:.....|...:...::|     :|.|....::|     .:|...|
Frog   566 TKSGFSNRYRPTWRPTREPLNVDSVFRSEKRKNAAYSPLSPFSEDSGKEMATNEFREIANSESKD 630

  Fly   589 -----------GLTMPEHLN--QPR---RRDSGNWSGDRNSASSASSTTLDNPYL--------YM 629
                       |...|..|:  |||   |.:||..|.:|||.|..|   :|.|..        |.
Frog   631 KHQFKYRSWGIGRGAPHFLDHQQPRLIQRMESGYESSERNSNSPIS---MDLPISENCSAFREYH 692

  Fly   630 VAKR-GVAAVPQSPTRHGLPYDPGYDSFSLSSTDS-------YPPKH--------------ALNP 672
            ..|. |.|     ||...:|  ....|.:|...||       ..|.|              .|..
Frog   693 SRKSPGTA-----PTWRNIP--KSQSSSALDMADSASSVWVKVHPTHMAVESNVPMKSELDELQE 750

  Fly   673 QLA-------------KIPEAAMGVVP------------NGGAMPHGHGNGQLALSGDCEKLCHE 712
            ::|             |..|||||..|            |.|.            |...|:...|
Frog   751 EVARRAREQELRWKREKEIEAAMGFNPRPKRFLDLDELQNQGR------------SESFERSMQE 803

  Fly   713 ADQLLEKSRLVEESHDLETALVLCNAAAGRARAAMDAPYSNPHTMTFARMKHNTCVMRARSLHRR 777
            ||.:.|:|..:|:..|..:||.|||.|..:.|.||....|:.|....|..|...|:.:||||..|
Frog   804 ADSVYEQSVRLEQKGDYTSALALCNEAISKIRFAMHDARSSTHCRAIADKKLQMCIRKARSLQDR 868

  Fly   778 ILVEKGAETEAMPELKHMREGSTSSVKHVRQNSKDRTLEKEQQQLQFQQIQQIQQIHQIQQQIPA 842
            :      :...:|:                ..|.|..|.      |.:.|.|......|.:|:|.
Frog   869 M------QLPTIPQ----------------PPSPDYPLP------QGEAINQSTSDQAISEQVPV 905

  Fly   843 SIEI-YATLPKRKSPLKALASASACDDNAIEYEQE-KQLATSPGKPERESRSLFGRKDKEKEKRS 905
            :..: ..|..|...|...|....||....:....| ..|:.|...|..::.|
Frog   906 NRPVMLETNTKEDYPSNPLFHPLACSHELLPLSSESSNLSASEQSPHSKAFS------------- 957

  Fly   906 RSEDRNKLTREFSLTETLLVNAKDTLKKHKEDKDEKKEKDKSGKKQHKIRRKLLMGGLIRRKNRS 970
                 |.|....||....||::                 .|....::|::.:....||:..:.:
Frog   958 -----NFLAPYNSLDSEGLVSS-----------------PKEAVFENKVKSEAYSQGLVNEQTK- 999

  Fly   971 MPDLTEAVDDSTANAGITHHPHYPAQGVTTAGTLLGTSVDDSAVGLGKHGHGMSGYISEGHFDYS 1035
                ||.|                            .:|......:|:...|..|.::......|
Frog  1000 ----TERV----------------------------KNVSPDKCKVGEENEGKEGLLTLHKVKLS 1032

  Fly  1036 G--SGSASNSGAGSNPNPNLERSKLMRKSFHGSGRQLTMVPKVAPPPPMRTSSTLTPQQQQQQQQ 1098
            |  |||.          |:|        .|..:.|..|..|..:.||.....|..|.:....:..
Frog  1033 GIKSGSL----------PSL--------LFPWARRTQTQSPDRSNPPSHCNKSVSTDKCVSTETG 1079

  Fly  1099 QFHHEANLSNLSAMSSNTSISEDSCQTIITTCAQVHSEQSPLKDLQMLVAQDELPLPPPMELPPY 1163
            :.:.:....|......|||:|....    ..|:..:|.::      :|..|.||..|.|.:
Frog  1080 ESNKQMGSCNDITPPGNTSLSLQQA----NLCSSANSHEA------LLDKQGELCGPEPCK---- 1130

  Fly  1164 PSPPHSSCHSRQASEDF------------------------PPPPPPELDLEPLNQQLSQLQAL- 1203
            ...|.:....|..:|.|                        ..|.|.:....||:.: |.||.|
Frog  1131 SEAPKNKGLVRSLAEQFQRLQGGSPKLNNFGVNCTGVDIGEKKPLPEQQSFSPLDNK-SSLQPLV 1194

  Fly  1204 ---EAASKQQRQQLE--------SLEGTTSILAQLQQRQHLLKLRKEQANHPGAATTDATWLKEL 1257
               ..||..::..|.        .::|::..|...|..      ..|:...||       |:...
Frog  1195 IHENKASCTEQIDLSPDCLGRSFDIKGSSIHLVDNQNN------GSEKKETPG-------WVVNA 1246

  Fly  1258 QAKQANDLRAMQRKLEASS----PSSV------RDLTHRF-------------------EQTSIR 1293
            ...|........:|::.:|    |.||      .|:|..:                   :..|||
Frog  1247 PLNQGKLFYKGGKKVKFASTVHLPGSVPMEQWAEDVTRYYNDKLESIGDKPKVGHTVSLKPKSIR 1311

  Fly  1294 ---SYASQELLSQPGQSQQLGQLRTQMNGLPNGNAKMDVDEVDAMPAVRNSLPAALSAHQLLPKP 1355
               |.:|.:|..:..:.:::..|:|..|.           .:.|.|. ||....:.:|.|...||
Frog  1312 YGLSKSSIDLRQEWNRDEEISDLQTLYNA-----------SLQACPN-RNMQWRSENARQGFGKP 1364

  Fly  1356 KYEMTQSQIAEEIREVELLNTMVQQTLNQNGAAALPKRVKKKSVS--FCDQVILVATAGNE---- 1414
            ..|.|..      |.|        ||....|.:..|.:..:.::|  ....|..|...|::
Frog  1365 LLENTAG------RRV--------QTTAGKGLSRTPTKEMEHNLSGTTFSPVPKVTHGGDQSRES 1415

  Fly  1415 EDDDFIPNPILERVLRTA------------------QHPNEKVT---------AQMIQQQQQNMM 1452
            |||:........|:.|:.                  :.|||:..         :.......||..
Frog  1416 EDDELYSAENFRRLARSLSGTVISGKEEAVVSSQSFEAPNERKPLMDSSHCSHSSSFHPYSQNPS 1480

  Fly  1453 RLQTEAQPRQQQVQQLQQPS------PMLG---RPAGATADMQRYVQRMQQQQQQQQQQQQQQQQ 1508
            .|..|.   |....|||.||      .|:|   ||:|. .:.|:.:....:.:..|..:|.
Frog  1481 VLSFEP---QHYPTQLQHPSFEGLAPSMVGAAHRPSGG-PNFQKVLAMSDRGENVQGNEQS---- 1537

  Fly  1509 QQQQQQQQQQQQQQQQQQHQELYRQQQLHRTSMSGIASQQHLQQLDAQYTTMPRPLHHSQLGSYS 1573
                                         |.::|              |.|.||....|...:.:
Frog  1538 -----------------------------RMALS--------------YATFPRAPRLSATPTAT 1559

  Fly  1574 VTLQKHQQLQQQQQQQQQQQAPQQLSLGYFSNGSVATSEQVP---LPSPYQRVPLPH-----GYQ 1630
            .:.:.:..|.||...:.|.........|:.|.||......|.   :.||..|...|.     ||.
Frog  1560 ASQRSYAVLGQQTNNRDQNVPSHYRWSGHTSQGSAPDKHMVNSSFMTSPGWRSQSPQTSGYGGYS 1624

  Fly  1631 PAAAGP 1636
            .::|.|
Frog  1625 NSSAYP 1630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ec	NP_001096877.1	Peptidase_C19	183..410	CDD:239072	117/231 (51%)
usp54	XP_004915986.1	UCH	33..350	CDD:395355	140/319 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1750
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002086
OrthoInspector	1	1.000	-	-		otm49167
Panther	1	1.100	-	-	O	PTHR22975
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.100