DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2901 and Xpr1

DIOPT Version :9

Sequence 1:	NP_570077.1	Gene:	CG2901 / 31338	FlyBaseID:	FBgn0029679	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_035403.1	Gene:	Xpr1 / 19775	MGIID:	97932	Length:	695	Species:	Mus musculus

Alignment Length:	690	Identity:	271/690 - (39%)
Similarity:	396/690 - (57%)	Gaps:	68/690 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTYESHLTIEWRQQYMRYGDLKELIKQGVENAPSPLTSSDYEVQAYYKAFEETFLTECQSE 65
            |||.:...:|:|.|||:||::|...|:::....:.|||...:.:..|:.|:..|||.|...|:.|
Mouse     1 MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKE 65

  Fly    66 LTGVNNFFLEKLLEARRKHGHLKLQLLAYSREPGHTGSDSSLSQR---------AERSQKKLMTT 121
            |..:|.|:.|||.||:|:...|:.:|.:.......:...::|.||         .||.|.:  ..
Mouse    66 LAKINTFYSEKLAEAQRRFATLQNELQSSLDVQKESSGVTTLRQRRKPVFHLSHEERVQHR--NI 128

  Fly   122 RQLRYAYAEFYLSLVLIQNYQSLNETGFRKICKKYDKNMRSVAAGRWFVENVLDAPFTDVRLLQR 186
            :.|:.|::||||||:|:||||:||.||||||.||:||.:.:.....|.|.:|..|||...:.:.:
Mouse   129 KDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVIHVEVAPFYTCKKINQ 193

  Fly   187 MTIEVEDLYTTHLANGDRSLAMEKLRVPPLG--EPTPPSMVFRAGIALGMLIML---LVATAI-- 244
            :..|.|.:.|..|.:|||..||::|||||||  :|.|....||.|:..|:.|:|   ||..|:
Mouse   194 LISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVFAAVFK 258

  Fly   245 -----SYWKRAPLEDHTPGLMRLFRGPFTWVIFNFYMAANVAGWQQAGVNHILIFEIDPRSHLQP 304
                 :.|.          |:|::||.|..:.|.|.:..|..||:||||||:||||::||::|..
Mouse   259 LETDRTVWP----------LIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSH 313

  Fly   305 ATFLEIACTFGILWALSMLGFLYNDLIGVSDPYVFPLGLILIMVGLLVVPLPIMNWPARWWTIKL 369
            ....|||...||||.||:|...:.. |.:...||:||.|...||..|:.|.....:.:|:|.:||
Mouse   314 QHLFEIAGFLGILWCLSLLACFFAP-ISIIPIYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKL 377

  Fly   370 VGRVITAPLHYVGFADFWMGDQMNSLVSCIVDHYYTVRFYAISWLRYDRVNNCFEPDVMVP---- 430
            :.||.|||.|.|||||||:.||:|||...::|..|.:.||:.. |::|........|...|
Mouse   378 LFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSFE-LKWDESKGLLPNDPQEPEFCH 441

  Fly   431 --------ITMCLPGWFRFAQCLRRFRDSGSKSMSYLINAGKYSTTFLVVLFSTL-RRNSEGGYA 486
                    |..|:|.|.||.|||||:||: .::..:|:|||||||||..|.|:.| ..:.|..::
Mouse   442 KYSYGVRAIVQCIPAWLRFIQCLRRYRDT-RRAFPHLVNAGKYSTTFFTVTFAALYSTHEEQNHS 505

  Fly   487 NTFSNPYTWLFLSSCVVATIYCYLWDVIRDFGLFRIMRGERIFLRKQLVYPQ-AFYYFVIVENLV 550
            :|....|.|:|.  |::::.|..:||:..|:|||....||..|||:::|||| |:||..|:|:::
Mouse   506 DTVVFFYLWVFF--CIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVI 568

  Fly   551 LRLFWAVEFTIL------YHNLMTPYNMRTISSILEITRRFIWNYVRLENEHLFNCGNFRATRDI 609
            ||..|.::.:|.      ..|::.     |:.:.||:.|||:||:.|||||||.|||.|||.|||
Mouse   569 LRFAWTIQISITATFKPHVGNIIA-----TVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDI 628

  Fly   610 HLAALNPRQERMLESMMDESDGVSNRRKS-----NERIRL 644
            .:|.||...:.:||.|||:.|||.||:|:     |:.|.|
Mouse   629 SVAPLNADDQTLLEQMMDQEDGVRNRQKNRSWKYNQSISL 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2901	NP_570077.1	COG5408	1..162	CDD:227695	65/169 (38%)
		SPX_XPR1_like	2..158	CDD:269898	62/164 (38%)
		EXS	260..597	CDD:281164	143/356 (40%)
Xpr1	NP_035403.1	SPX_XPR1_like	2..165	CDD:269898	62/164 (38%)
		SPX	3..169	CDD:281146	63/167 (38%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000250\|UniProtKB:P43585	158..165		4/6 (67%)
		EXS	286..616	CDD:281164	137/339 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..695
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	1	1.010	-	-		QHG54286
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.830