Protein Alignment fd3F and foxo1b

DIOPT Version :10

• Sequence 1: NP_001356931.1
• Gene: fd3F / 31336
• FlyBaseID: FBgn0264954
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_001076326.1
• Gene: foxo1b / 567969
• ZFINID: ZDB-GENE-080425-3
• Length: 629
• Species: Danio rerio
• Alignment Length: 700
• Identity: 122/700 - (17%)
• Similarity: 182/700 - (26%)
• Gaps: 356/700 - (50%)

  Fly   216 QSAGRRTSSGSVSGANEATEADFEDKNLSWLLNFKFDEFPHLSP--HNQIHGQAVNL--PEGSAP 276
            |.....|||.:.|...|....||.: :||.|  .:.:::|...|  .|..|.|. |.  |:...|
Zfish    36 QPGNSNTSSPAPSVKPEQGIVDFIN-SLSLL--EETEDYPDEKPVLLNDFHCQD-NCAHPQQQHP 96

  Fly   277 --PHPPST---AVPIATSPCSSSSPSSASAASASASAISTNQSLGSGLVDQRARSPKSCSSAAMP 336
              |:|..|   .||...:|.|.|||::|...|:|:..
Zfish    97 QQPNPQLTHPQQVPPLPAPASGSSPAAAQRKSSSSRR---------------------------- 133

  Fly   337 AALGGGGNGSAGASAAGGVAGVGSTKTGRKFEELVMEVTSELDGNDMIVAEHVVVEDTSSKAPKK 401
               ...||
Zfish   134 ---NAWGN--------------------------------------------------------- 138

  Fly   402 PPFTYTELIEYALEDKGE--LTVSGIYQWISDRFPYYKSNDDR-----WKNSVRHNLS------- 452
              .:|.:||..|:|...|  ||:|.||:|:....||:|...|.     ||||:|||||
Zfish   139 --MSYADLITKAIESSPEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVR 201

  Fly   453 -------------INPHFRKGVKAP---------------------------QGA---------- 467
                         :||...|..|:|                           ||.
Zfish   202 VQNEGTGKSSWWMLNPEGGKSGKSPRRRATSMDNNSKFTKSRGRAAKKKMSLQGGLDGGSNSPGS 266

  Fly   468 --------------------GHLWAISSGDSAE-------------------------------- 480
                                |:....:|.|::.
Zfish   267 QYPKWLGSPNSHSNDDFEPWGNFRTRASSDASTLSGRRSPFLPEEDEAAEVHIGYPGTKLGGPLP 331

  Fly   481 --NVLAWEHKKQRL--DLFFKMESINRERIQQHQQQQQLQQHQQQHQQHSPQQKQHSAAQQQHMP 541
              :.:|..|..:.:  :|...:..|:.:...|..|:.|... .....|.||....:::......|
Zfish   332 SLSEVAGHHGSENMMDNLLENLNLISPKNNTQGSQEAQTAL-SSPLMQGSPGYPSYTSPNMGPQP 395

  Fly   542 QAS----SCMYDEAAV------AVATLTQ--------------------------------EMMQ 564
            |..    .|:|.:..|      ::.||:.                                |:||
Zfish   396 QVQQDYRKCLYGQGGVGGLNPISIPTLSDSKPGGYGPFVGQYNCAPGLLKELLTADADPRGELMQ 460

  Fly   565 TNSG---------------GGSTET------------------------------------SQQQ 578
            :..|               ||...|                                    |.:.
Zfish   461 SGEGQPVLPSYASQGQMAQGGKMITHPHLHAHPRSLHQLPSPAMGLNGCAMLPHGHPVRLSSMKP 525

  Fly   579 QQQQQHHHH-------------------HSHQNHQNHNQHHQRLLPFNDLLSDDELRKTAGQILN 624
            |....||.|                   |.|....:|:..|...|| :||  ||       .:::
Zfish   526 QPHLPHHTHLGRGGGEAGMPSYTNGNGFHRHGAIAHHHHSHPERLP-SDL--DD-------MLID 580

  Fly   625 GIHREVEVQSVNSIISTYHDVLLDNDYL----NPIHKDVVVTESVLRQQH 670
            .:..|.:|:.|      .||.|:|.|.|    :|:......|.||....|
Zfish   581 QLDVECDVERV------LHDTLMDGDALDFNFDPMSSQQSFTHSVKTSTH 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fd3F	NP_001356931.1	Forkhead	401..473	CDD:459732	33/155 (21%)
foxo1b	NP_001076326.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		6/17 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		15/76 (20%)
		COG5025	<117..400	CDD:227358	56/373 (15%)
		FH_FOXO1	127..225	CDD:410834	32/187 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..308		10/96 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	359..397		7/38 (18%)
		FOXO_KIX_bdg	403..>462	CDD:465228	8/58 (14%)
		FOXO-TAD	569..609	CDD:435506	15/55 (27%)