DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HIP-R and TOM71

DIOPT Version :9

Sequence 1:	NP_001014719.2	Gene:	HIP-R / 31335	FlyBaseID:	FBgn0029676	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_011985.1	Gene:	TOM71 / 856517	SGDID:	S000001159	Length:	639	Species:	Saccharomyces cerevisiae

Alignment Length:	327	Identity:	72/327 - (22%)
Similarity:	114/327 - (34%)	Gaps:	78/327 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SEDEKSLSDPESDVELDMEGVIEADSDPAQPMGNYSKKAT----------------EEEVEQASE 128
            :|||..|.|         :|.:.:.|:..:...|..|:..                |.::.|...
Yeast    62 NEDEADLKD---------DGSVVSGSNKRKKKKNKRKRNNKAKSGEGFDYPSLPNGEPDIAQLKG 117

  Fly   129 LRAQAASAYGQQ------------KFDEAIALYTKAIELSPGNALFHAKRGQAFLKLKKPNACIR 181
            |......||..|            .|:|||..|..||||.|...:|::.....::........|.
Yeast   118 LSPSQRQAYAVQLKNRGNHFFTAKNFNEAIKYYQYAIELDPNEPVFYSNISACYISTGDLEKVIE 182

  Fly   182 DCDVALELNSDLAAGYKFRGRARRLLGDFELAAHDLR-QACKLDFDEETDEWLKEVTPNAKKIEQ 245
            ....|||:..|.:.....|..|...||:|..|..||. .:...|||..:.|.:.|...|
Yeast   183 FTTKALEIKPDHSKALLRRASANESLGNFTDAMFDLSVLSLNGDFDGASIEPMLERNLN------ 241

  Fly   246 HRLKQERRQAERKIKERQRDQRRARKEQEKHNASSGGSSGEFSGGNPGNGNMSDILGAM-SDPEV 309
                   :||.:.:.|               |.|.  ..|..|...|.|.:::...|.. |..||
Yeast   242 -------KQAMKVLNE---------------NLSK--DEGRGSQVLPSNTSLASFFGIFDSHLEV 282

  Fly   310 SAAIQDILSNPGNITKYASNPKIYNLIKKIVPGGDVGAAFGQAGEKAGKPSEPKPKKDSADFVDD 374
            |:    :.::....|.||   .:.:.::::....|.|  :..|.:...|.::......||:.|||
Yeast   283 SS----VNTSSNYDTAYA---LLSDALQRLYSATDEG--YLVANDLLTKSTDMYHSLLSANTVDD 338

  Fly   375 GL 376
            .|
Yeast   339 PL 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIP-R	NP_001014719.2	Hip_N	10..47	CDD:271228
		TPR_11	125..190	CDD:290150	20/76 (26%)
		TPR_2	126..159	CDD:285020	14/44 (32%)
		TPR repeat	126..154	CDD:276809	10/39 (26%)
		TPR repeat	159..189	CDD:276809	4/29 (14%)
		TPR repeat	194..222	CDD:276809	8/28 (29%)
		STI1	299..336	CDD:128966	8/37 (22%)
TOM71	NP_011985.1	3a0801s09	9..636	CDD:273380	72/327 (22%)
		TPR repeat	127..155	CDD:276809	7/27 (26%)
		TPR repeat	160..190	CDD:276809	4/29 (14%)
		TPR repeat	195..218	CDD:276809	6/22 (27%)
		TPR repeat	345..373	CDD:276809
		TPR repeat	378..406	CDD:276809
		TPR repeat	411..441	CDD:276809
		TPR repeat	446..471	CDD:276809
		TPR repeat	480..508	CDD:276809
		TPR repeat	513..559	CDD:276809
		TPR repeat	564..588	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930