DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HIP-R and TOM70

DIOPT Version :9

Sequence 1:	NP_001014719.2	Gene:	HIP-R / 31335	FlyBaseID:	FBgn0029676	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_014278.3	Gene:	TOM70 / 855602	SGDID:	S000005065	Length:	617	Species:	Saccharomyces cerevisiae

Alignment Length:	288	Identity:	61/288 - (21%)
Similarity:	111/288 - (38%)	Gaps:	66/288 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SEDEKSLSDPESDVELDMEGVIEA---DSDPAQPMG-----NYSKKA---TEEEVEQASELRAQA 133
            ::|||.   ...|.:.:.||..::   .:.|..|:.     ::|.||   .||:.:.|..|:.:.
Yeast    45 NKDEKK---DTKDSQKETEGAKKSTAPSNPPIYPVSSNGEPDFSNKANFTAEEKDKYALALKDKG 106

  Fly   134 ASAYGQQKFDEAIALYTKAIELSPGNALFHAKRGQAFLKLKKPNACIRDCDVALELNSDLAAGYK 198
            ...:..:|:|:||..|..|:||.. :.:|::.....::.:......:.....||||..|.:....
Yeast   107 NQFFRNKKYDDAIKYYNWALELKE-DPVFYSNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLL 170

  Fly   199 FRGRARRLLGDFELAAHDLR-QACKLDFDEETDEWLKEVTPNAKKIEQHRLKQERRQAERKIKER 262
            .|..|...||.|..|..||. .:...||::.:.|.:.|...|             :||..|:||:
Yeast   171 RRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLN-------------KQAMSKLKEK 222

  Fly   263 QRD-------------QRRARKEQEKHNASSGGSSGEFSG--------GNPGNGNMSDILGAMSD 306
            ..|             |....::.::.|..|..|...|.|        .|....|.:|
Yeast   223 FGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESNEAD------- 280

  Fly   307 PEVSAAIQDILSNPGNITKYASNPKIYN 334
                   :::::...|:  |..:|:.|:
Yeast   281 -------KELMNGLSNL--YKRSPESYD 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIP-R	NP_001014719.2	Hip_N	10..47	CDD:271228
		TPR_11	125..190	CDD:290150	14/64 (22%)
		TPR_2	126..159	CDD:285020	10/32 (31%)
		TPR repeat	126..154	CDD:276809	8/27 (30%)
		TPR repeat	159..189	CDD:276809	3/29 (10%)
		TPR repeat	194..222	CDD:276809	8/28 (29%)
		STI1	299..336	CDD:128966	5/36 (14%)
TOM70	NP_014278.3	3a0801s09	1..614	CDD:273380	61/288 (21%)
		TPR repeat	99..127	CDD:276809	8/27 (30%)
		TPR repeat	131..161	CDD:276809	3/29 (10%)
		TPR repeat	166..189	CDD:276809	6/22 (27%)
		TPR repeat	330..358	CDD:276809
		TPR repeat	363..391	CDD:276809
		TPR repeat	396..426	CDD:276809
		TPR repeat	431..459	CDD:276809
		TPR repeat	465..493	CDD:276809
		TPR repeat	498..537	CDD:276809
		TPR repeat	542..567	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930