DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HIP-R and ST13

DIOPT Version :9

Sequence 1:	NP_001014719.2	Gene:	HIP-R / 31335	FlyBaseID:	FBgn0029676	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_003923.2	Gene:	ST13 / 6767	HGNCID:	11343	Length:	369	Species:	Homo sapiens

Alignment Length:	389	Identity:	155/389 - (39%)
Similarity:	216/389 - (55%)	Gaps:	66/389 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MQTGDLKKLKYFIDFALENPTFLNMPQLQFVKDFVEKFGGTVPPGQFNGGSAGGKCPFGGVAGAK 69
            |....:.:|:.|:....::|:.|:..:::|::::||..||.|||                 |..|
Human     1 MDPRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVPP-----------------ATQK 48

  Fly    70 ANEPANAPEDSEDEKSL---------SDPESDVELDMEGVIEADSDPAQPMGNYSKKATEEEVEQ 125
            |....|..|:..|.|.:         |..|||:|:|.|||||.|:|..|.||:.:.:.|||.::|
Human    49 AKSEENTKEEKPDSKKVEEDLKADEPSSEESDLEIDKEGVIEPDTDAPQEMGDENAEITEEMMDQ 113

  Fly   126 ASELRAQAASAYGQQKFDEAIALYTKAIELSPGNALFHAKRGQAFLKLKKPNACIRDCDVALELN 190
            |::.:..|..|....:..:||.|:|.||:|:|..|:.:|||...|:||:||||.|||||.|:|:|
Human   114 ANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEIN 178

  Fly   191 SDLAAGYKFRGRARRLLGDFELAAHDLRQACKLDFDEETDEWLKEVTPNAKKIEQHRLKQERRQA 255
            .|.|..||:||:|.||||.:|.|||||..|||||:||:....||||.|.|:||.:||.|.||::.
Human   179 PDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKEVQPRAQKIAEHRRKYERKRE 243

  Fly   256 ERKIKER-------QRDQRRARKEQEKHNASS-----------GGSSGEFSGGNPGNGN------ 296
            ||:||||       :.:..||::|:|....|.           ||..|.|.||.||.|.
Human   244 EREIKERIERVKKAREEHERAQREEEARRQSGAQYGSFPGGFPGGMPGNFPGGMPGMGGGMPGMA 308

  Fly   297 --------MSD--ILGAMSDPEVSAAIQDILSNPGNITKYASNPKIYNLIKKIVPGGDVGAAFG 350
                    :||  :|.||.||||..|.||:..||.|::||.||||:.|||.|:      .|.||
Human   309 GMPGLNEILSDPEVLAAMQDPEVMVAFQDVAQNPANMSKYQSNPKVMNLISKL------SAKFG 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIP-R	NP_001014719.2	Hip_N	10..47	CDD:271228	9/36 (25%)
		TPR_11	125..190	CDD:290150	30/64 (47%)
		TPR_2	126..159	CDD:285020	11/32 (34%)
		TPR repeat	126..154	CDD:276809	8/27 (30%)
		TPR repeat	159..189	CDD:276809	17/29 (59%)
		TPR repeat	194..222	CDD:276809	17/27 (63%)
		STI1	299..336	CDD:128966	21/38 (55%)
ST13	NP_003923.2	Hip_N	3..43	CDD:271228	9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..97		25/75 (33%)
		PLN03088	114..>233	CDD:215568	62/118 (53%)
		TPR 1	114..147		11/32 (34%)
		TPR repeat	147..177	CDD:276809	17/29 (59%)
		TPR 2	148..181		19/32 (59%)
		TPR 3	182..215		21/32 (66%)
		TPR repeat	182..210	CDD:276809	17/27 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..300		12/43 (28%)
		STI1	316..361	CDD:407696	24/44 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160203
Domainoid	1	1.000	127	1.000	Domainoid score	I5365
eggNOG	1	0.900	-	-		E1_KOG1308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2921
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3075
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53615
OrthoDB	1	1.010	-	-		D1282821at2759
OrthoFinder	1	1.000	-	-		FOG0003789
OrthoInspector	1	1.000	-	-		mtm8611
orthoMCL	1	0.900	-	-		OOG6_104991
Panther	1	1.100	-	-	LDO	PTHR45883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3214
SonicParanoid	1	1.000	-	-		X3148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800