DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HIP-R and st13

DIOPT Version :9

Sequence 1:	NP_001014719.2	Gene:	HIP-R / 31335	FlyBaseID:	FBgn0029676	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_956063.1	Gene:	st13 / 564225	ZFINID:	ZDB-GENE-030131-5395	Length:	362	Species:	Danio rerio

Alignment Length:	360	Identity:	151/360 - (41%)
Similarity:	211/360 - (58%)	Gaps:	32/360 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MQTGDLKKLKYFIDFALENPTFLNMPQLQFVKDFVEKFGGTVP-PGQFNGGSAGGKCPFGGVAGA 68
            |....:.:||.|:....|||:.|::|::.|.|.::...|.::| |...:..|..|.||..|.|..
Zfish     1 MDPRKVTELKAFVQLCNENPSVLHLPEMSFFKTWLLGMGASIPSPTMNDSSSCKGSCPCDGGAKK 65

  Fly    69 KANEPANAPEDSEDEKSLSDPESDVELDMEGVIEADSDPAQPMGNYSK-KATEEEVEQASELRAQ 132
            .|.:|..|| .||.|      ||::|:|.|||||.|:|..|.||::.. :.|||.::||:|.:.:
Zfish    66 AAPKPEPAP-PSESE------ESEIEIDNEGVIEPDTDDPQEMGDFENLEVTEEMMDQANEKKTE 123

  Fly   133 AASAYGQQKFDEAIALYTKAIELSPGNALFHAKRGQAFLKLKKPNACIRDCDVALELNSDLAAGY 197
            |..|.|.....:|:.|:|:||:|:|..|:.:|||...::|::||||.|||||.|:.:|.|.|..|
Zfish   124 AIDALGDGDLQKALDLFTEAIKLNPKLAILYAKRASVYVKMQKPNAAIRDCDRAISINPDSAQPY 188

  Fly   198 KFRGRARRLLGDFELAAHDLRQACKLDFDEETDEWLKEVTPNAKKIEQHRLKQERRQAERKIKER 262
            |:||:|.:|||.:|.:|.||..|||||:|||....||||.|.|.||..||.|.||::.||:|:.|
Zfish   189 KWRGKAHKLLGHWEESARDLAMACKLDYDEEASAMLKEVQPKANKIIDHRRKYERKREEREIRAR 253

  Fly   263 Q-------RDQRRARKEQEKHNASSGGSSGE-------------FSGGNPGNGNM---SDILGAM 304
            |       .:..||::|:|....:.||..|.             |.||.||..|:   .::|.||
Zfish   254 QERVKKAREEHERAQREEEARQQAGGGGGGAGAGGFPGFPGGAGFPGGMPGFNNLFNDPEVLMAM 318

  Fly   305 SDPEVSAAIQDILSNPGNITKYASNPKIYNLIKKI 339
            .||||.||.||:..||.||.||.|||||..||.|:
Zfish   319 QDPEVMAAFQDVAQNPANIAKYQSNPKIMALINKL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIP-R	NP_001014719.2	Hip_N	10..47	CDD:271228	11/36 (31%)
		TPR_11	125..190	CDD:290150	28/64 (44%)
		TPR_2	126..159	CDD:285020	12/32 (38%)
		TPR repeat	126..154	CDD:276809	9/27 (33%)
		TPR repeat	159..189	CDD:276809	15/29 (52%)
		TPR repeat	194..222	CDD:276809	14/27 (52%)
		STI1	299..336	CDD:128966	22/36 (61%)
st13	NP_956063.1	TPR repeat	185..213	CDD:276809	14/27 (52%)
		STI1	311..350	CDD:128966	22/38 (58%)
		Hip_N	3..43	CDD:271228	11/39 (28%)
		TPR_11	116..182	CDD:290150	28/65 (43%)
		TPR repeat	117..145	CDD:276809	9/27 (33%)
		TPR repeat	150..180	CDD:276809	15/29 (52%)
		TPR_11	151..215	CDD:290150	33/63 (52%)
		TPR_1	151..183	CDD:278916	16/31 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596552
Domainoid	1	1.000	97	1.000	Domainoid score	I7197
eggNOG	1	0.900	-	-		E1_KOG1308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2921
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3044
OMA	1	1.010	-	-		QHG53615
OrthoDB	1	1.010	-	-		D1282821at2759
OrthoFinder	1	1.000	-	-		FOG0003789
OrthoInspector	1	1.000	-	-		otm26410
orthoMCL	1	0.900	-	-		OOG6_104991
Panther	1	1.100	-	-	LDO	PTHR45883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3214
SonicParanoid	1	1.000	-	-		X3148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800