DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HIP-R and Spag1

DIOPT Version :9

Sequence 1:	NP_001014719.2	Gene:	HIP-R / 31335	FlyBaseID:	FBgn0029676	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	442	Identity:	95/442 - (21%)
Similarity:	148/442 - (33%)	Gaps:	161/442 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLKKLKYFIDFALENPTFLNMPQL-QFVKDFVEKFGGTVPPGQFNGGSAGGKCPFGGVAGAKANE 72
            :|||:|       :|   ||:|.: :..|..:||...|..|                ....||..
  Fly   106 ELKKVK-------QN---LNLPSVRKLSKIDLEKESKTEKP----------------KPAPKATS 144

  Fly    73 PANAPEDSEDEKSLS-------DPESDVELDMEGVIEADSDPAQP-MGNYSKKATEE-------- 121
            |:|........||..       ||:.:: |.|:...|.|.:..:. :.|:||..|.:
  Fly   145 PSNTKNKEARIKSTDYRKWDKYDPDEEI-LRMDLNEERDQEQREKIISNHSKSVTTDKLQSERDS 208

  Fly   122 ---------------EVEQASEL-RAQAASAYGQQKFDEAIALYTKAIELSPGNALFHA--KRGQ 168
                           |.||.:|. |.:...::..::::.||..|..:|...|.||: ||  .|..
  Fly   209 LYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDPENAV-HAYNNRAV 272

  Fly   169 AFLKLKKPNACIRDCDVALELNS-------DLAAGYKFRGRARRLLGDFELAAHDLRQACKLDFD 226
            |.|||||..:.|.||...|:::.       .:|..:...|:....|..::..         |||:
  Fly   273 AHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKL---------LDFE 328

  Fly   227 ----------EETDEWLKEVTPNAKKIEQHRLKQERRQAERKIKER----QRDQRRARKEQEKHN 277
                      |:....|.||.|::              |.|.|.|.    |......:||.||
  Fly   329 PDNAIAKKAVEKLTSMLGEVAPSS--------------ATRLIIEEIDPPQLKTSEPKKEAEK-- 377

  Fly   278 ASSGGSSGEFSGGNPGNGNMSDILGAMSDPEVSAAIQDILSNPGNITKYASNP---KIYNLIKKI 339
                                       |:|.|....:.::|        |..|   |.|:|.:.:
  Fly   378 ---------------------------SEPTVVKKPEPVVS--------AKKPPPIKDYDLAELV 407

  Fly   340 VPGGDVGAAFGQAGE---------KAGKPSEPK-----PKKDSADFVDDGLD 377
            .|...|.:....|.|         |.|.|.:|:     ||:.......|.|:
  Fly   408 KPNRMVKSNLVSAAEALGNKMQASKGGAPKKPQSPPMTPKETLLRLPQDNLN 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIP-R	NP_001014719.2	Hip_N	10..47	CDD:271228	12/37 (32%)
		TPR_11	125..190	CDD:290150	23/67 (34%)
		TPR_2	126..159	CDD:285020	7/33 (21%)
		TPR repeat	126..154	CDD:276809	5/28 (18%)
		TPR repeat	159..189	CDD:276809	15/31 (48%)
		TPR repeat	194..222	CDD:276809	3/27 (11%)
		STI1	299..336	CDD:128966	8/39 (21%)
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	22/66 (33%)
		TPR repeat	229..257	CDD:276809	5/27 (19%)
		TPR repeat	262..293	CDD:276809	15/31 (48%)
		TPR_11	266..329	CDD:290150	18/71 (25%)
		TPR	266..297	CDD:197478	12/30 (40%)
		TPR repeat	298..326	CDD:276809	3/36 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930