DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HIP-R and Dpit47

DIOPT Version :9

Sequence 1:	NP_001014719.2	Gene:	HIP-R / 31335	FlyBaseID:	FBgn0029676	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001260729.1	Gene:	Dpit47 / 35565	FlyBaseID:	FBgn0266518	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	222	Identity:	54/222 - (24%)
Similarity:	90/222 - (40%)	Gaps:	38/222 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PEDSEDE---------KSLSDPESDVELDMEGVIEADSDPAQPMGNYSKKATEEEVEQASELRAQ 132
            |||...|         |....|..||....||:.:...||        ::.|.:|:  |...:..
  Fly    43 PEDRWQEEMDKHPFFMKRAPQPGDDVHPMFEGLQKLKYDP--------EENTRDEL--ALNYKED 97

  Fly   133 AASAYGQQKFDEAIALYTKAIELSPGN----ALFHAKRGQAFLKLKKPNACIRDCDVALELNSDL 193
            .......:||..||..:|:.|:....|    |:.:..|..|...:|...:.:.|...||....|.
  Fly    98 GNFYMKHKKFRMAIYSFTEGIKTKTDNPDVLAVLYNNRSAAHFFIKNYRSSLSDAQRALFYKPDY 162

  Fly   194 AAGYKFRGRARRLLGDFELAAHDL-RQACK--LDFDEETDEWLKEVTPN-AKKIE-QHRLKQERR 253
            .   |.|.|:.:..  :||...|| .|.|:  |:.|.:.:..:..:..| .||:| :...::|..
  Fly   163 T---KARWRSAQCA--YELERFDLCTQMCEELLEVDVDNEVAIALLHKNKMKKLEIERNQRKEAA 222

  Fly   254 QAERKIK--ERQRD---QRRARKEQEK 275
            :|:|::.  .|.||   ||..:.:.:|
  Fly   223 EAKRRLTRFHRLRDAIEQRAIKFDDQK 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIP-R	NP_001014719.2	Hip_N	10..47	CDD:271228
		TPR_11	125..190	CDD:290150	15/68 (22%)
		TPR_2	126..159	CDD:285020	7/32 (22%)
		TPR repeat	126..154	CDD:276809	6/27 (22%)
		TPR repeat	159..189	CDD:276809	8/33 (24%)
		TPR repeat	194..222	CDD:276809	8/28 (29%)
		STI1	299..336	CDD:128966
Dpit47	NP_001260729.1	3a0801s09	84..>179	CDD:273380	23/101 (23%)
		TPR repeat	91..119	CDD:276809	6/27 (22%)
		TPR repeat	124..158	CDD:276809	8/33 (24%)
		TPR repeat	163..191	CDD:276809	9/32 (28%)
		TPR repeat	197..227	CDD:276809	6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930