DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HIP-R and Stip1

DIOPT Version :9

Sequence 1:	NP_001014719.2	Gene:	HIP-R / 31335	FlyBaseID:	FBgn0029676	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_477354.1	Gene:	Stip1 / 33202	FlyBaseID:	FBgn0024352	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	64/262 - (24%)
Similarity:	106/262 - (40%)	Gaps:	61/262 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VEQASELRAQAASAYGQQKFDEAIALYTKAIELSPGNALFHAKRGQAFLKLKKPNACIRDCDVAL 187
            :::.:||:.:...|...:|||||:|.||:||.|...|.:.::.|..||.|..|....:.|.:..:
  Fly     1 MDKVNELKEKGNQALSAEKFDEAVAAYTEAIALDDQNHVLYSNRSAAFAKAGKFQEALEDAEKTI 65

  Fly   188 ELNSDLAAGYKFRGRARRLLGDFELAAHDLRQACKLDFDEETDEWL----KEVTPNA-------- 240
            :||.....||..:|.|...|.||..|.....:..|.|   .|:..|    .|.|.:|
  Fly    66 QLNPTWPKGYSRKGAAAAGLNDFMKAFEAYNEGLKYD---PTNAILLQGRMETTASALSFMQSQG 127

  Fly   241 ---KKIEQHRLKQER-------------RQAERKIK---ERQRDQRRARKEQEKHNASSGGSSGE 286
               ..::..:.:..|             :.||.:::   |.|:::..||||:|..||:.
  Fly   128 DIPMDVDPQQARSRRAPSPPPAKPAEPPKPAEPRVEDMTEEQKNKYFARKEKELGNAAY------ 186

  Fly   287 FSGGNPGNGNMSDILGAMSDPEVSAAIQDILSNPGNITKYASNPKIY-------NLIKKIVPGGD 344
                     ...|...|:.  ...|||:   .:|.:||.|.:...::       ..||:...|.:
  Fly   187 ---------KKKDFETALK--HYHAAIE---HDPTDITFYNNIAAVHFERKEYEECIKQCEKGIE 237

  Fly   345 VG 346
            ||
  Fly   238 VG 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIP-R	NP_001014719.2	Hip_N	10..47	CDD:271228
		TPR_11	125..190	CDD:290150	21/64 (33%)
		TPR_2	126..159	CDD:285020	14/32 (44%)
		TPR repeat	126..154	CDD:276809	12/27 (44%)
		TPR repeat	159..189	CDD:276809	7/29 (24%)
		TPR repeat	194..222	CDD:276809	8/27 (30%)
		STI1	299..336	CDD:128966	9/43 (21%)
Stip1	NP_477354.1	TPR_11	6..69	CDD:290150	22/62 (35%)
		TPR repeat	7..32	CDD:276809	11/24 (46%)
		TPR repeat	37..67	CDD:276809	7/29 (24%)
		TPR_11	40..103	CDD:290150	18/65 (28%)
		TPR repeat	72..100	CDD:276809	8/27 (30%)
		TPR_11	175..237	CDD:290150	19/81 (23%)
		TPR repeat	175..203	CDD:276809	11/44 (25%)
		TPR_1	181..208	CDD:278916	8/46 (17%)
		TPR_12	205..278	CDD:290160	9/35 (26%)
		TPR repeat	208..238	CDD:276809	6/29 (21%)
		TPR repeat	250..278	CDD:276809
		TPR_1	250..>276	CDD:278916
		TPR_11	309..375	CDD:290150
		TPR repeat	310..338	CDD:276809
		TPR_1	<317..343	CDD:278916
		TPR repeat	343..373	CDD:276809
		TPR_1	378..411	CDD:278916
		TPR repeat	378..406	CDD:276809
		STI1	439..478	CDD:128966
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840