Protein Alignment Rala and NKIRAS2

DIOPT Version :10

• Sequence 1: NP_525063.1
• Gene: Rala / 31332
• FlyBaseID: FBgn0015286
• Length: 201
• Species: Drosophila melanogaster
• Sequence 2: NP_060065.2
• Gene: NKIRAS2 / 28511
• HGNCID: 17898
• Length: 191
• Species: Homo sapiens
• Alignment Length: 195
• Identity: 54/195 - (27%)
• Similarity: 89/195 - (45%)
• Gaps: 31/195 - (15%)

  Fly    13 KVIMVGSGGVGKSALTLQFMYDEFVEDYE--PTKADSYRKKVVLD-GEEVQIDILDTAGQEDYAA 74
            ||::.|...|||:::..|.:|...|...|  .|:.|.|...:..| |...|:...||.|..|.|.
Human     6 KVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFYDTRGLRDGAE 70

  Fly    75 IRDNYFRSGEGFLCVFSITDDESFQATQEFREQILRVKNDESIPFLLVGNKCDLNDKRKVPLSEC 139
            :..:.|...:|::.|:|....||||..:..:::|.:.|:.:.:..:::||||||.::|:|....
Human    71 LPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGNKCDLQEQRRVDPDV- 134

  Fly   140 QLRAQQWA-------------------VPYVETSAKTRENVDKVFFDLMREIRSRKTEDSKATSG 185
               ||.||                   .|:|..::|..:...|..|.|     |||.:.|.:..|
Human   135 ---AQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPL-----SRKNKGSGSLDG 191

  Fly   186  185
            Human   192  191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rala	NP_525063.1	RalA_RalB	12..174	CDD:206710	49/182 (27%)
NKIRAS2	NP_060065.2	Small GTPase-like	1..191		53/193 (27%)
		P-loop containing Nucleoside Triphosphate Hydrolases	6..168	CDD:476819	45/165 (27%)
		Effector region	35..43		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..191		7/26 (27%)