DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rala and MRAS

DIOPT Version :9

Sequence 1:	NP_525063.1	Gene:	Rala / 31332	FlyBaseID:	FBgn0015286	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_001078518.1	Gene:	MRAS / 22808	HGNCID:	7227	Length:	208	Species:	Homo sapiens

Alignment Length:	205	Identity:	92/205 - (44%)
Similarity:	127/205 - (61%)	Gaps:	5/205 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKKPTAGPALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDT 66
            |..|:.....:|:::||.|||||||||:||....||.||:||..|||.|...:|.:...:|:|||
Human     4 SAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDT 68

  Fly    67 AGQEDYAAIRDNYFRSGEGFLCVFSITDDESFQATQEFREQILRVKNDESIPFLLVGNKCDLNDK 131
            ||||:::|:|:.|.|:|:|||.|:|:||..||:....|.:.|||||:.||.|.:||.||.||...
Human    69 AGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHL 133

  Fly   132 RKVPLSECQLRAQQWAVPYVETSAKTRE-NVDKVFFDLMREIRSRKTEDS----KATSGRAKDRC 191
            ||:...:.:..|.:..:||:|||||... ||||.|.||:|.||.:..|.|    |.|..|.....
Human   134 RKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRAT 198

  Fly   192 KKRRLKCTLL 201
            ...:|:|.:|
Human   199 GTHKLQCVIL 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rala	NP_525063.1	RalA_RalB	12..174	CDD:206710	81/162 (50%)
MRAS	NP_001078518.1	M_R_Ras_like	12..176	CDD:133345	80/163 (49%)
MRAS	NP_001078518.1	Effector region	42..50		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820