DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mnt and ARNT

DIOPT Version :9

Sequence 1:	NP_001162651.1	Gene:	Mnt / 31331	FlyBaseID:	FBgn0023215	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_001659.1	Gene:	ARNT / 405	HGNCID:	700	Length:	789	Species:	Homo sapiens

Alignment Length:	753	Identity:	137/753 - (18%)
Similarity:	241/753 - (32%)	Gaps:	203/753 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 GNGLSNGHSSPRSQLAAAATAHDYEYSAAGVANGHSEGRPHVSEDDNSSINNNNNNNNTHPPQQ- 170
            |..:::|:|.|..|...|......:.......:...||.......|:..::|:.........:|
Human    18 GPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQS 82

  Fly   171 ---------QQHSAAGRTTTTRITTTPAILTKLMGNSVTPASNTTSLPTSTPSVTTSPPASTDFM 226
                     :.||...|....::|   |.:|:|  :.:.|          |.|.....|.....:
Human    83 SADKERLARENHSEIERRRRNKMT---AYITEL--SDMVP----------TCSALARKPDKLTIL 132

  Fly   227 LLAAAATSATSATPATATSAAATAASNPAKRKLSSIAEIPSKFLVVSDAKG---VYSAHTHPNGF 288
            .:|.:...:...|..|:|..:         .|.|.:.:...|.|::..|.|   :.|..|....:
Human   133 RMAVSHMKSLRGTGNTSTDGS---------YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVY 188

  Fly   289 AADSLGVDNNETMIKKLMQNLQSQRQQQSLQQLR-SLRPAEISLTPPPAATRKVDISNSRTRSYS 352
            .:||:....|:...:.....|..|.....:.:|| .|..:|.:||     .|.:|:.....:.
Human   189 VSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALT-----GRILDLKTGTVKK-- 246

  Fly   353 LSNVSAARDQQDHPQHQQHANHMQIQQHYGYMRSNIGGVIYGLHKDSAD-------SAASSACGA 410
                          :.||.:..|.:    |..||.|..:..|  ..|.|       |...:.|..
Human   247 --------------EGQQSSMRMCM----GSRRSFICRMRCG--SSSVDPVSVNRLSFVRNRCRN 291

  Fly   411 GAGAAAVGMS----------IASSAPAAGSQLSAHHHTGHG--------GRRRTTSSNSNGAGTR 457
            |.|:...|..          |.:..||..|........|.|        ||.:.|||
Human   292 GLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSS-------- 348

  Fly   458 EVHNKLEKERRAQLKECYDLLKKVLPMGDEDRKKTSNL-TILDTAHKYVNSLSH----------- 510
                          ..|.|:.....|.....|.....: |.:|  |:.|.::.:
Human   349 --------------PNCTDMSNVCQPTEFISRHNIEGIFTFVD--HRCVATVGYQPQELLGKNIV 397

  Fly   511 EVCEQE---------AKIEKLAKQKIELQKRLKQ-----LSLRRESPPTDQQIIPQADKAVCLAT 561
            |.|..|         .::.||..|.:.:..|.:.     |.:|..|.........:.:..:|..|
Human   398 EFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNT 462

  Fly   562 TATTAP----PTAASGHNGTTILFDAGNACATGQLTTVINKTNGGATAAASSKHNGNHTGGATTT 622
            ....:.    ||                      |:..|.:...|.||....:............
Human   463 NVKNSSQEPRPT----------------------LSNTIQRPQLGPTANLPLEMGSGQLAPRQQQ 505

  Fly   623 LTPAMGIMTIKNGNGSNGNMLAISP---TG-GHNHQLHQ----------------HHNGSPAGSP 667
            ....:.::..::|..|..:...:.|   || .|:..|.:                :||.: |...
Human   506 QQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNIN-ADQS 569

  Fly   668 SGIGATT-GAT---ITRGSPTPSTPSPSPSSSSSGVSLSTSFMGGSSSSSSSSSSSSSSSSSSSS 728
            .||.::| .||   .::|:..|.||.|:.:..:||::...:.:..|:|:....:..|..|:.:..
Human   570 KGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQG 634

  Fly   729 SSPT---------QQQQIITPTATARSVGLKFHGGAGA 757
            ::||         ..||:.| .|||::...:|  |.|:
Human   635 ATPTWTPTTRSGFSAQQVAT-QATAKTRTSQF--GVGS 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mnt	NP_001162651.1	HLH	457..512	CDD:238036	8/66 (12%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97		13/78 (17%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:28396409	88..128		11/54 (20%)
		HLH	91..143	CDD:278439	12/66 (18%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250\|UniProtKB:P53762	112..264		36/197 (18%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250\|UniProtKB:P53762	112..168		12/76 (16%)
		PAS	163..269	CDD:279347	26/130 (20%)
		PAS	166..230	CDD:214512	13/63 (21%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250\|UniProtKB:P53762	167..171		1/3 (33%)
		PAS_11	362..462	CDD:291273	16/101 (16%)
		PAS	362..458	CDD:238075	15/97 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..492		7/48 (15%)
		Med3	<523..>734	CDD:288447	35/151 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..789
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910