DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mnt and tfe3a

DIOPT Version :9

Sequence 1:	NP_001162651.1	Gene:	Mnt / 31331	FlyBaseID:	FBgn0023215	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_571923.2	Gene:	tfe3a / 114834	ZFINID:	ZDB-GENE-010919-2	Length:	539	Species:	Danio rerio

Alignment Length:	582	Identity:	127/582 - (21%)
Similarity:	197/582 - (33%)	Gaps:	203/582 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 KLMGNSVTPASNTTSLPTSTP--SVTTSPPASTDFMLLAAA-----------ATSA----TSATP 240
            :|.|..:||:.:.||....||  ||.||.......::...|           |:||    |.:||
Zfish    73 ELKGQPITPSGSLTSADPVTPTGSVMTSRVLMRQELMRQQAQDQERREAQKQASSAQQRLTDSTP 137

  Fly   241 ATATSAAATAASN-PAKRKLSSIAEIPSKFLVVSDAKGVYSAHTHPNGFAADSLGVDNNETMIKK 304
                  |.:.||| |||.     .::|.:.|.|         .||             .|...|.
Zfish   138 ------AISVASNLPAKP-----TQVPVEVLKV---------QTH-------------LENPTKY 169

  Fly   305 LMQNLQSQRQQQSLQQL--RSLRPAEISLTPPPAATRKVDI--SNSRTRSYSLSNVSAARDQQDH 365
            .:|..|.|:.:|.|...  ..:....::.:|||..:...::  :.|.|.|..|:.:|...::::
Zfish   170 HIQQAQRQQVKQYLSHTLGNKIASQTLATSPPPQPSSAPELAPAASSTPSSPLAVLSLGSNKEE- 233

  Fly   366 PQHQQHANHMQIQQHYGYMRSNIGGVIYGLHKDSADSAASSACGAGAGAAAVGMSIASSAPAAGS 430
                                  |..||     |...|..||...........|:.:.|:.|.:|:
Zfish   234 ----------------------IEDVI-----DDIISLESSLNDEFMTLIDSGLQLPSTLPVSGN 271

  Fly   431 QLSAHHHTGHGGRRRTTSSNSNGAGTREV---------------------HNKLEKERRAQLKEC 474
            .|..:...|... ...|.|||..|..:.|                     ||.:|:.||....:.
Zfish   272 LLDVYSSQGMAA-PTITVSNSCPADLQNVKREMSDAEAKAIMKERQKKDNHNLIERRRRFNTNDR 335

  Fly   475 YDLLKKVLPMGDEDRKKTSNLTILDTAHKYVNSL------SHEVCEQEAKIE------KLAKQKI 527
            ...|..::|...:...:.:..|||..:..|:..|      |.|:..::.|:|      .|..|::
Zfish   336 IKELGALIPKSSDPELRWNKGTILKASVDYIRKLQKEQQRSKEMETRQKKLEHANRSLMLRIQEL 400

  Fly   528 ELQKRLKQLSLRRESPP-TDQQII-----PQAD-KAVCLATTATT-----APPTAASGHNGT-TI 579
            |:|.||..||..:.|.. |..|.:     |..| ....|:.|.||     :||::.|...|| |.
Zfish   401 EMQARLHGLSSSQLSDSLTQTQTLTLEHNPNTDLSKTLLSITQTTPSSFLSPPSSTSSVGGTVTS 465

  Fly   580 LFDAGNACATGQLTTVINKTNGGATAAASSKHNGNHTGGATTTLTPA----MGIMTIKNGNGSNG 640
            ..:.| ..:.|:|                    .:||   .:..:||    ||:          |
Zfish   466 PLELG-TLSFGEL--------------------DDHT---ASVFSPALMADMGL----------G 496

  Fly   641 NML-----AISPTGGHNHQLHQHHNGSPAGSPSGIGATTGATITRGSPTPSTPSPSPSSSSS 697
            ::|     |:||.||                              ..|..|..||..|.:||
Zfish   497 DILMDDSGALSPVGG------------------------------ADPLLSAVSPGASKTSS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mnt	NP_001162651.1	HLH	457..512	CDD:238036	14/81 (17%)
tfe3a	NP_571923.2	MITF_TFEB_C_3_N	101..238	CDD:292573	35/192 (18%)
		HLH	314..374	CDD:238036	12/59 (20%)
		DUF3371	402..538	CDD:288684	43/191 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910