DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mnt and htr2b

DIOPT Version :9

Sequence 1:	NP_001162651.1	Gene:	Mnt / 31331	FlyBaseID:	FBgn0023215	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	XP_004914439.1	Gene:	htr2b / 101731179	XenbaseID:	XB-GENE-989949	Length:	478	Species:	Xenopus tropicalis

Alignment Length:	160	Identity:	32/160 - (20%)
Similarity:	61/160 - (38%)	Gaps:	35/160 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 TSATPATATSAAATAASNPAKRKLSSIAEIPSKFLVVSDAKGVYSAHTHPNGFAADSLGVDNNET 300
            |.:|.:|......|..|:|.|   ..:.|.|.|       .|.::       |..:.|.:....:
Frog   256 TWSTVSTVFQRDMTPGSSPEK---IVMLEGPRK-------DGTFN-------FTGEELPIRRLSS 303

  Fly   301 MIKKLMQNLQSQRQQQSLQQLRSLRPAEISLTPPPAATRKVDISNSRTRSYSLSNVSAARDQQDH 365
            :.||.||.:.:  :|::.:.|..:....:.:..|...|             ::::|...:||.|.
Frog   304 VGKKSMQTITN--EQRASKVLGIVFFLFVFMWCPFFIT-------------NVTSVLCGKDQCDE 353

  Fly   366 PQHQQHANHMQIQQHYGYMRSNIGGVIYGL 395
            ...:.   .|.|....||:.|.:..::|.|
Frog   354 DVIKM---LMDIFVWVGYISSGVNPLVYTL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mnt	NP_001162651.1	HLH	457..512	CDD:238036
htr2b	XP_004914439.1	7tm_GPCRs	50..396	CDD:391938	32/160 (20%)
		TM helix 1	52..76	CDD:341315
		TM helix 2	85..107	CDD:341315
		TM helix 3	124..146	CDD:341315
		TM helix 4	169..185	CDD:341315
		TM helix 5	211..234	CDD:341315
		TM helix 6	316..341	CDD:341315	4/37 (11%)
		TM helix 7	357..382	CDD:341315	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910