Protein Alignment Thoc2 and tho2

DIOPT Version :9

• Sequence 1: XP_006257566.1
• Gene: Thoc2 / 313308
• RGDID: 1561623
• Length: 1621
• Species: Rattus norvegicus
• Sequence 2: NP_608646.3
• Gene: tho2 / 326153
• FlyBaseID: FBgn0031390
• Length: 1642
• Species: Drosophila melanogaster
• Alignment Length: 1679
• Identity: 683/1679 - (40%)
• Similarity: 983/1679 - (58%)
• Gaps: 188/1679 - (11%)

  Rat    11 EWIKNWEKSGRGDFL----HLCRILSENKSHDSSTYRDFQQ----ALYELSYHVIKGNLKHEQAS 67
            |..|:.:||||.:||    |..:..::...:|.:..  |:|    |:|:|.:..::...|.:...
  Fly    63 EVFKHLDKSGRSEFLKYLKHQLQDAADTPVYDKNGV--FKQGISNAIYQLLWQTLRFTHKKDIVL 125

  Rat    68 SVLNDISEFREDMPSILADVFCILDIETNCLEE--KSKRDYFTQLVLACLYLVSDTVLKERLDPE 130
            .:|.::.....|.||::.||..|||.||:.:.:  :.:|..|.|||.....::.:::|||||:.:
  Fly   126 HLLLEVVALHADFPSLIVDVVNILDSETSLITDGLQEERHAFVQLVKDLDRVIPESLLKERLEID 190

  Rat   131 TLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGTITSDLILEN 195
            ||:..|::| ::.|..|.:|:||||:|||::|||.|||:||:||||.||.|:.....|.:.|::.
  Fly   191 TLQEAGIVK-NKSFYSKFIKVKTKLYYKQRRFNLFREESEGFAKLITELNQEFDENTTPESIMDI 254

  Rat   196 IKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPSG 260
            |||||||||||||||||:|:|.||.||:..:.||.||.|||.  ....:|.:||:||..:::  .
  Fly   255 IKSLIGCFNLDPNRVLDIIIESFETRPDRWNLFIPLLRSYMP--TGAIICEVLGYKFCHFKD--S 315

  Rat   261 ETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEYKREIVEAKQIVRKLTMVVLSSEKLDE 325
            .||.|||.|.|:||:..:|.|:|:||.|.|.|..|..:::.::.:|:::||||.: :.:::|.||
  Fly   316 RTPRSLYHVCALLLKHGVIALNDVYVWLTPNDGSIKADWEEDLADAREMVRKLNL-IQTNKKEDE 379

  Rat   326 RDKEKDKDDEKV--EKPPDNQKLGLLEALLKIGDWQHAQNIMDQMPPYYAASHKLIALAICKLIH 388
            :|.......:|.  ||...|||.||.|||||:|||::|..|:.::|.......:.||.||..|||
  Fly   380 KDPPPPPSVKKFNEEKYNANQKFGLCEALLKVGDWENAYKIIQKLPEQAVVLQEPIARAIADLIH 444

  Rat   389 ITVEPLYRR--VGVPKGAKGSPVSALQNKR--APKQVESFEDLRRDVFNMFCYLGPHLSHDPILF 449
            ::||.:|.:  ...|.|.:.|.....::.:  |..|.:.|.|||:..:.|...|||.:.:|.:|.
  Fly   445 LSVENIYYKKCFKAPAGRRPSRNRLYEDSKLVAKMQAKEFGDLRKYTWPMANVLGPAMHYDTVLM 509

  Rat   450 AKVVRIGKSFMKEFQSDG-----SKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELW 509
            .|::||.:..:.:...|.     ...|.::....|:|.|    |..:||||..:|.|..||||:|
  Fly   510 YKLIRIMRKLVVDMGVDSLNGPPPNSEAEQHYYDIMSSL----DACILPSLLYLDNNCSMSEEIW 570

  Rat   510 GMFKTFPYQHRYRLYGQWKNETYNGHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHS 574
            .:.|.|||..||.||.:|||::|..||.|::.........|.:|||::|||||..||.:||.||.
  Fly   571 AVLKYFPYHFRYSLYARWKNDSYQLHPNLIRRCGLAQRDIKALMKRVSKENVKQLGRLVGKYSHC 635

  Rat   575 NPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWL 639
            .|.:||||||.|||.|||||.||.|.|||||:|::|.|.|||||:|....:.|.|.|.|::|.||
  Fly   636 APGLLFDYILLQIQIYDNLIGPVCDLLKYLTALSFDCLGYCIIESLTLTGRLRFKDDGTSLSLWL 700

  Rat   640 QSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMT 704
            ||||||||.:::||.|:|:|||||||||||:.||.|||||:|:|.||||:|..||||.:||:||.
  Fly   701 QSLASFCGTIYKKYSIELSGLLQYVANQLKSQKSLDLLILREIVHKMAGVESCEEMTNDQLQAMC 765

  Rat   705 GGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQE-GGEKHLKLVGK 768
            |||||:.|.|||.|:|||||||.|||:||.::|||:.:|||||||::.||::| ....||||||.
  Fly   766 GGEQLRGEAGYFSQVRNTKKSSNRLKEALANNDLAVAICLLMAQQKHCVIYRETAAHSHLKLVGN 830

  Rat   769 LYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDEL 833
            |||||.|||||||.||.|..|.::|::|:|||..:..|:|...|.||||:|||:.|.|:.|||:|
  Fly   831 LYDQCQDTLVQFGTFLGSTYSVDEYVERLPSIITMLREYHINTDVAFFLARPMFTHQINQKYDQL 895

  Rat   834 KKSEKGSKQ---QHKVHKYITSCEMVMAPVHEAVVSLHVAKVWDDISPQFYATFWSLTMYDLAVP 895
            :|.:..:|:   ..|:.||:.:.:::|.|:.|:|..||.:|||:||||||..|||||:||||.||
  Fly   896 RKDDPNAKKLTTTQKLQKYLEATQLIMNPIVESVRPLHSSKVWEDISPQFLVTFWSLSMYDLHVP 960

  Rat   896 HTSYEREVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEK 960
            :.||:|||.|||...:...:.::...:|.|||:||..||.:||.:|.|||.|||.::.|||:.:|
  Fly   961 NESYQREVAKLKQLAQQAAEGKDSNQSKNKKEQERYIALMEKLNDERKKQHEHVDKISQRLQEQK 1025

  Rat   961 DNWLL---AKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFS 1022
            |:|.|   .||.||:|||:|||||:||||.|:|:||:|||:||..:|..||.||||||||||:|.
  Fly  1026 DSWFLLRSGKSAKNDTITQFLQLCLFPRCTFTALDALYCAKFVHTIHNLKTSNFSTLLCYDRIFC 1090

  Rat  1023 DIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATG-FDGGNKAD 1086
            ||.|:|.||||.||:|||||||.|||||.|||:|:|.:.|||.|||||:|..|.:. |...|  |
  Fly  1091 DITYSVTSCTEGEATRYGRFLCAMLETVMRWHADQAVFNKECANYPGFVTKFRVSNQFSEAN--D 1153

  Rat  1087 QLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVNKI 1151
            .:.|||:|||.||||||:|||.|.||::.::..|||.||:|.:|||.||.:..|.|.:||:|:|:
  Fly  1154 HVGYENYRHVCHKWHYKITKAIVFCLDSKDFMQIRNALIILMRILPHYPVLSKLAQIIERKVDKV 1218

  Rat  1152 CQEEKEKRPDLYALAMGYSGQLKSRKSHMIPENEFHH-KDPPPRNAVASVQNGPGGGTSSSSIGS 1215
            .:|||.|||||||:|..|.||||.:..||:.|:.||. .:.|.:.:..|| ..|...|.|..:..
  Fly  1219 REEEKTKRPDLYAIASSYIGQLKLKTPHMLKESVFHQIAERPNKESPTSV-GAPAAATRSDKLSP 1282

  Rat  1216 ASKSDES-------GAEETDKSRERSQCGTKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEK 1273
            .|.|..:       ||.....|.::|.. .:...||:|||   ..|....|..:|..:.......
  Fly  1283 TSPSGNTQGTRAPGGAAPFYNSEQKSVI-KEPDAKAASTT---RESKSQRGEGNNVTLVSTATST 1343

  Rat  1274 VKEKEKEKKEKTPATTPEARVLGKESKEKPKEERPNKDDKARETKERTPKSDKEKEKFKKEEKAK 1338
            ....|:|.|::   ..|..|.....||:..:|:..|..:.:|:::.|  ..|.|:::..::::..
  Fly  1344 ASNNERESKQR---DLPAPRESQSRSKDDQQEQANNGSNGSRQSESR--NRDVERDRHDQQDQRS 1403

  Rat  1339 DEKFKTTVPSVESKSTQERE---REKEPSR---ERDVAKEMKSKENVKGGEK------------- 1384
            ....:::...|..|...|.|   |.:|.|:   |.:..:..:.|.:.:|||:
  Fly  1404 ISSHRSSRDIVRVKERTEAELHQRSRERSQRLEELEAQQRKREKTSRRGGEERIRHGDGVETVDL 1468

  Rat  1385 -------------------PPVS----GSLKSPVPRSDISEPDR-EQKRRKIDTHPSPSHSSTVK 1425
                               ..||    |||.......:..|.:: :.||||:::    |.||:.|
  Fly  1469 VGSTDNRHYEEFEGRMRDLSSVSNESNGSLHHRQRSHETIEFEKVDSKRRKLES----STSSSKK 1529

  Rat  1426 VTDILPKVPLGSENYASSPVISIHFLQDSLIDLKDSSAKLYINHNPPPLSKSKEREMDK-----K 1485
            |.:::..|                         |.:.|           .|:|||..||     :
  Fly  1530 VEELVDSV-------------------------KKARA-----------LKTKERNKDKLSDEER 1558

  Rat  1486 DLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDITKRRKEENGTMGVSKHKSESPCESQYP 1550
            |..|.|:..|:|::.||.:..|.||               ||:.:||             |.:.
  Fly  1559 DARKDRKLGRKRDRVDESNSNEHKR---------------RREGQNG-------------EEEL- 1594

  Rat  1551 NEKDKEKNKSKSSGKEKGSSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDS 1604
              :|:|:::.||. :|:      ..||.|: ..||...||.::.:...|..|.|
  Fly  1595 --RDRERHREKSP-RER------SHEKFDR-ERGGASGSRAEERQYISKSARSS 1638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Thoc2	XP_006257566.1	THOC2_N	11..566	CDD:292752	218/575 (38%)
		Thoc2	568..642	CDD:288568	44/73 (60%)
		Tho2	874..1173	CDD:288156	176/302 (58%)
		SDP_N	1475..>1584	CDD:289079	29/113 (26%)
tho2	NP_608646.3	THOC2_N	133..627	CDD:292752	201/503 (40%)
		Thoc2	629..703	CDD:288568	44/73 (60%)
		Tho2	939..1240	CDD:288156	176/302 (58%)
		PRP38_assoc	1570..1639	CDD:289628	26/108 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354009
Domainoid	1	1.000	378	1.000	Domainoid score	I821
eggNOG	1	0.900	-	-		E1_KOG1874
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69669
Inparanoid	1	1.050	1153	1.000	Inparanoid score	I197
OMA	1	1.010	-	-		QHG55273
OrthoDB	1	1.010	-	-		D979205at2759
OrthoFinder	1	1.000	-	-		FOG0003449
OrthoInspector	1	1.000	-	-		otm45156
orthoMCL	1	0.900	-	-		OOG6_102850
Panther	1	1.100	-	-	LDO	PTHR21597
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2346
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770