DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Parg and PARG

DIOPT Version :10

Sequence 1:NP_477321.2 Gene:Parg / 31329 FlyBaseID:FBgn0023216 Length:723 Species:Drosophila melanogaster
Sequence 2:NP_003622.2 Gene:PARG / 8505 HGNCID:8605 Length:976 Species:Homo sapiens


Alignment Length:567 Identity:239/567 - (42%)
Similarity:333/567 - (58%) Gaps:50/567 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSKSPDGGISEIETEEE----------PENLANSLDDSWRGVSMEAIHRNRQPFELENLPPVTAG 55
            :.|:.|....:.||:.:          |.:|  |.|..|.|..:|.:  .|.|.....||.:...
Human   417 LPKAEDRRKEQWETKHQRTERKIPKYVPPHL--SPDKKWLGTPIEEM--RRMPRCGIRLPLLRPS 477

  Fly    56 NLHRVMYQLPIRET--PPRPYKSPGK--WDSEHVRLPCAPESKYPRENPDGSTTIDFRWEMIERA 116
            ..|.|..::.:...  .|:|:.:..|  ||::||::||:.::.||.|:.:|..|...|||:|:.|
Human   478 ANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTA 542

  Fly   117 LLQPIKTCEELQAAIISYNTTYRDQWHFRALHQLLDEELDESETRVFFEDLLPRIIRLALRLPDL 181
            ||......:.|:.||:.||..|..:|.|.||....|:.|:|:|.:..::.:||.::::||.||::
Human   543 LLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNI 607

  Fly   182 IQSPVPLLKHHKNASLSLSQQQISCLLANAFLCTFPRRNTLKRKSEYSTFPDINFNRLYQSTGPA 246
            ...|:||||...|.|:::||:||:.||||||.|||||||. |.|||||::||||||||::.....
Human   608 CTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNA-KMKSEYSSYPDINFNRLFEGRSSR 671

  Fly   247 VLEKLKCIMHYFRRVCPTERDASNVPTGVVTFVRRSGLPEHLIDWSQSAAPLGDVPLHVDAEGTI 311
            ..||||.:..|||||  ||:.    |||:|||.|:|  .|...:|.:...||  ..|||..||||
Human   672 KPEKLKTLFCYFRRV--TEKK----PTGLVTFTRQS--LEDFPEWERCEKPL--TRLHVTYEGTI 726

  Fly   312 EDEGIGLLQVDFANKYLGGGVLGHGCVQEEIRFVICPELLVGKLFTECLRPFEALVMLGAERYSN 376
            |:.|.|:|||||||:::||||...|.|||||||:|.|||::.:||||.|...|.|::.|.|:||.
Human   727 EENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSE 791

  Fly   377 YTGYAGSFEWSGNFEDSTPRDSSGRRQTAIVAIDALHFAQSHHQYREDLMERELNKAYIGFVHWM 441
            |||||.::.||.:.||.:.||...||.|.|||||||||.:...|:..:.|.|||||||.||:.  
Human   792 YTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLR-- 854

  Fly   442 VTPPPG--------VATGNWGCGAFGGDSYLKALLQLMVCAQLGRPLAYYTFGNVEFRDDFHEMW 498
                ||        ||||||||||||||:.||||:|::..|...|.:.|:|||:.|...|.:.|.
Human   855 ----PGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMH 915

  Fly   499 LLFRNDGTTVQQLWS-ILRSYSRLIKEKSSKEPRENKASKKKLYDFI 544
            :.......||..::. :||.|:...:..|:..|      ..|||.||
Human   916 IFLTERKLTVGDVYKLLLRYYNEECRNCSTPGP------DIKLYPFI 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PargNP_477321.2 PARG_cat 155..492 CDD:461528 176/344 (51%)
PARGNP_003622.2 A-domain. /evidence=ECO:0000269|PubMed:23251397 1..456 9/40 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..69
Nuclear localization signal. /evidence=ECO:0000269|PubMed:15212953 10..16
PIP-box (PCNA interacting peptide). /evidence=ECO:0000269|PubMed:21398629 76..83
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..350
PARG_cat 581..909 CDD:461528 176/344 (51%)
Catalytic. /evidence=ECO:0000269|PubMed:23251397 610..795 107/195 (55%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.