DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Parg and parga

DIOPT Version :9

Sequence 1:	NP_001245511.1	Gene:	Parg / 31329	FlyBaseID:	FBgn0023216	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	XP_687541.4	Gene:	parga / 559134	ZFINID:	ZDB-GENE-070117-757	Length:	777	Species:	Danio rerio

Alignment Length:	569	Identity:	248/569 - (43%)
Similarity:	348/569 - (61%)	Gaps:	44/569 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SEIETEEEPENLANSLDDSWRGVSMEAIHRNRQPFELENLPPVTAGNLHRVMY--------QLPI 66
            |.:::|:.|   |...:..|||..:|.:  .|.|...:.||.:.|.:.|||:.        |:|:
Zfish   233 SSLKSEQVP---AEQEEPDWRGTPIENL--RRMPKCGQTLPHLRATDNHRVLIRTDLLKEGQVPV 292

  Fly    67 RETPPRPYKSPGKWDSEHVRLPCAPESKYPRENPDGSTTIDFRWEMIERALLQPIKTCEELQAAI 131
                |.|.|....||..:|::||:.::.:|.||.||| .:..|||:|..||....|:..:::.||
Zfish   293 ----PYPTKFRDSWDDMNVKMPCSEKNMFPMENEDGS-GVQSRWELIRSALEGECKSSLDIRDAI 352

  Fly   132 ISYNTTYRDQWHFRALHQLLDEELDESETRVFFEDLLPRIIRLALRLPDLIQSPVPLLKHHKNAS 196
            :||||.:..:|.|.||:.|..|.::..|.:..|..:||::::|.|..|.:...|:||||...|.|
Zfish   353 LSYNTAHAKRWDFTALNVLCTEGMENDEVQHLFNTILPKMVKLVLNTPKICTQPIPLLKTKMNQS 417

  Fly   197 LSLSQQQISCLLANAFLCTFPRRNTLKRKSEYSTFPDINFNRLYQSTGPAVLEKLKCIMHYFRRV 261
            |::||:||:|||||||.|||||||:  |||||:.:|:|||.||::.:....:||||.::.|||||
Zfish   418 LTMSQEQIACLLANAFFCTFPRRNS--RKSEYANYPEINFYRLFEGSSQRKIEKLKTLLCYFRRV 480

  Fly   262 CPTERDASNVPTGVVTFVRRS--GLPEHLIDWSQSAAPLGDVPLHVDAEGTIEDEGIGLLQVDFA 324
              ||    ::|||:|||.|:|  ..|:    |..|.:||..  ||:..:|||||:|.|:||||||
Zfish   481 --TE----SMPTGLVTFKRQSLTTFPK----WESSKSPLSH--LHITCKGTIEDQGYGMLQVDFA 533

  Fly   325 NKYLGGGVLGHGCVQEEIRFVICPELLVGKLFTECLRPFEALVMLGAERYSNYTGYAGSFEWSGN 389
            |:.:||||.|.|.|||||||:|.|||:|.:||||.|...|.|::.|.|:||.|:|||.||:|..|
Zfish   534 NRMVGGGVTGLGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSKYSGYAESFKWEDN 598

  Fly   390 FEDSTPRDSSGRRQTAIVAIDALHFAQSHHQYREDLMERELNKAYIGFVHWMVTP--PPGVATGN 452
            .:|..|||...||.|.|||:||||:.....|::.:.|.|||||||.||:...|.|  ...|||||
Zfish   599 HKDKIPRDGWQRRCTEIVAMDALHYRNFMDQFQPEKMTRELNKAYCGFMRPGVNPLNLSAVATGN 663

  Fly   453 WGCGAFGGDSYLKALLQLMVCAQLGRPLAYYTFGNVEFRDDFHEMWLLFRNDGTTVQQLWSILRS 517
            |||||||||:.||||||||..|:.||.:||:|||:.....|..::....:::..||..|:..|:.
Zfish   664 WGCGAFGGDTRLKALLQLMAAAEAGRDVAYFTFGDEALMRDVQDLHKFLKDNCVTVGSLYVYLKQ 728

  Fly   518 YSRLIKEKSSKEPRENKASKKKLYDFIKEELKKVRD-VPGEGASAEAGS 565
            ||.:: .|.:..|..|      ||.|:.|::....| .|.:..|..|.|
Zfish   729 YSSIV-SKQAHRPNIN------LYGFLYEKVGTNTDPEPSDSTSTTATS 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Parg	NP_001245511.1	PARG_cat	155..492	CDD:282834	178/340 (52%)
parga	XP_687541.4	PARG_cat	376..703	CDD:282834	178/340 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583643
Domainoid	1	1.000	337	1.000	Domainoid score	I1079
eggNOG	1	0.900	-	-		E1_KOG2064
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1694
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D353452at33208
OrthoFinder	1	1.000	-	-		FOG0004062
OrthoInspector	1	1.000	-	-		oto41590
orthoMCL	1	0.900	-	-		OOG6_102366
Panther	1	1.100	-	-	LDO	PTHR12837
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2730
SonicParanoid	1	1.000	-	-		X2814
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790