DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2875 and NOC4

DIOPT Version :9

Sequence 1:	NP_570069.1	Gene:	CG2875 / 31326	FlyBaseID:	FBgn0029672	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_015470.1	Gene:	NOC4 / 856267	SGDID:	S000006348	Length:	552	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	143/522 - (27%)
Similarity:	252/522 - (48%)	Gaps:	86/522 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DIKTLKGFVQLLKN--TPDNMPAGE-----------VMNTLEVIFKNLLKR--KAIDGTEKQGLK 84
            |.|.....::|:..  .|:|:...|           ||:..: ||:.|..|  ..:..::|..|:
Yeast    20 DRKQYNSIIKLINELVIPENVTQLEEDETEKNLRFLVMSLFQ-IFRKLFSRGDLTLPSSKKSTLE 83

  Fly    85 -------IKKLYE--ETWLL-LIENLLVDSQCSV-AVKVCMQLIKVEAKH-------PIAPNKGW 131
                   .:|:||  :|.|| :|.::..::...: ::.|.:||.::|:.|       |..|||.:
Yeast    84 KEQFVNWCRKVYEAFKTKLLAIISDIPFETSLGLDSLDVYLQLAELESTHFASEKGAPFFPNKTF 148

  Fly   132 P----TYWIRGM--LETLINSDTTPTTALANYGK--YCKNLDVLEITLTQLKSLVPDEDFKDSPI 188
            .    ..|...|  :|.:.:|..:....:..:.:  |.|..|:.....::...|:.|..::|..:
Yeast   149 RKLIIALWSSNMGEIEDVKSSGASENLIIVEFTEKYYTKFADIQYYFQSEFNQLLEDPAYQDLLL 213

  Fly   189 KAM-NFLSIVNLLDMGKSVLSTADYH---------VESAKKQTFNYELNRKRLNNLWATIMAKGN 243
            |.: .:|::||......||  .||..         :|:..|...|:|.|       |.:::  ..
Yeast   214 KNVGKWLALVNHDKHCSSV--DADLEIFVPNPPQAIENESKFKSNFEKN-------WLSLL--NG 267

  Fly   244 EVDEKLHRQILVVLLERVINHLNDPIQLTDFLMDSL-----HQFDGPIALLALQGIFTLMQKQNI 303
            ::..:.::.||::|.:|:|.|.:.|.:|.|||.||.     ::..|.:.:|||.|:|.||::.|:
Yeast   268 QLSLQQYKSILLILHKRIIPHFHTPTKLMDFLTDSYNLQSSNKNAGVVPILALNGLFELMKRFNL 332

  Fly   304 TYPDVYEKLYNMFYPRMFHNKYKARLFYLADIFLTSTHLPENLVAAFVKRLARLALQSPTEDAVI 368
            .||:.|.|||.:..|.:.|.||:||.|.|.|:||:||||..:|||:|:|:||||.|:||....|.
Yeast   333 EYPNFYMKLYQIINPDLMHVKYRARFFRLMDVFLSSTHLSAHLVASFIKKLARLTLESPPSAIVT 397

  Fly   369 MIRFVCNLLLRHTGLQKLIRASHAV-------DEVS----------DPYNQTETDPVKSEAINSS 416
            :|.|:.||:.:|.....::.....:       |:|:          ||::..|:||..:.|::||
Yeast   398 VIPFIYNLIRKHPNCMIMLHNPAFISNPFQTPDQVANLKTLKENYVDPFDVHESDPELTHALDSS 462

  Fly   417 LWEITLLQKHVVPEVANAARFINSSLPVMEFDLAPLLDRKECNIFDDELQSKAKQF-ALNYERPT 480
            |||:..|.:|..|.||..|:........:.:::...||....::.:.|...|.|.. .|.:|..|
Yeast   463 LWELASLMEHYHPNVATLAKIFAQPFKKLSYNMEDFLDWNYDSLLNAESSRKLKTLPTLEFEAFT 527

  Fly   481 NL 482
            |:
Yeast   528 NV 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2875	NP_570069.1	CBF	287..435	CDD:281851	65/164 (40%)
NOC4	NP_015470.1	CBF	317..481	CDD:397822	65/163 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343807
Domainoid	1	1.000	124	1.000	Domainoid score	I1216
eggNOG	1	0.900	-	-		E1_KOG2154
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40545
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004812
OrthoInspector	1	1.000	-	-		oto99648
orthoMCL	1	0.900	-	-		OOG6_102386
Panther	1	1.100	-	-	LDO	PTHR12455
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1838
SonicParanoid	1	1.000	-	-		X3394
TreeFam	1	0.960	-	-
	14	13.780