DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2875 and NOC4L

DIOPT Version :9

Sequence 1:	NP_570069.1	Gene:	CG2875 / 31326	FlyBaseID:	FBgn0029672	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_076983.1	Gene:	NOC4L / 79050	HGNCID:	28461	Length:	516	Species:	Homo sapiens

Alignment Length:	377	Identity:	117/377 - (31%)
Similarity:	212/377 - (56%)	Gaps:	17/377 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VAVKVCMQLIKVEAKHPIAPNKGW------PTYWIRGMLETLINSDTTPTTALANYGKYCKNLDV 166
            :|:...::.:::|..||:..:| |      |....:.::..|::.:...:..|:.:.:|....|.
Human   117 LALSALLKFVQLEGAHPLEKSK-WEGNYLFPRELFKLVVGGLLSPEEDQSLLLSQFREYLDYDDT 180

  Fly   167 LEITL---TQLKSLVPDEDFKDSPIKAMNFLSIVNLLDMGKSVLSTADYHVESAKK----QTFNY 224
            ...|:   ....:.|..:..:..|....|..::::.:.:.:...:.:.::|:.|:.    :..:.
Human   181 RYHTMQAAVDAVARVTGQHPEVPPAFWNNAFTLLSAVSLPRREPTVSSFYVKRAELWDTWKVAHL 245

  Fly   225 ELNRKRLNNLWATIMAKGNEVDEKLHRQILVVLLERVINHLNDPIQLTDFLMDSLHQFDGPIALL 289
            :.:|:....:|.:.:.  :::...|::::|:::.:.::..|..|..:.|||..:. ...|.::||
Human   246 KEHRRVFQAMWLSFLK--HKLPLSLYKKVLLIVHDAILPQLAQPTLMIDFLTRAC-DLGGALSLL 307

  Fly   290 ALQGIFTLMQKQNITYPDVYEKLYNMFYPRMFHNKYKARLFYLADIFLTSTHLPENLVAAFVKRL 354
            ||.|:|.|:.|.|:.|||.|.|||.:..|.:||.||:||.|:|||:||:|:|||..|||||.|||
Human   308 ALNGLFILIHKHNLEYPDFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRL 372

  Fly   355 ARLALQSPTEDAVIMIRFVCNLLLRHTGLQKLIRASHAVDEVSDPYNQTETDPVKSEAINSSLWE 419
            |||||.:|.|..::::.|:||||.||...:.|:...|..:..:|||:..|.||.:|.|:.|||||
Human   373 ARLALTAPPEALLMVLPFICNLLRRHPACRVLVHRPHGPELDADPYDPGEEDPAQSRALESSLWE 437

  Fly   420 ITLLQKHVVPEVANAARFINSSLPVMEFDLAPLLDRKECNIFDDELQSKAKQ 471
            :..||:|..|||:.||..||.:|.:.|..:||||:.....||:.:|:.|..:
Human   438 LQALQRHYHPEVSKAASVINQALSMPEVSIAPLLELTAYEIFERDLKKKGPE 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2875	NP_570069.1	CBF	287..435	CDD:281851	76/147 (52%)
NOC4L	NP_076983.1	CBF	310..453	CDD:281851	72/142 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147151
Domainoid	1	1.000	164	1.000	Domainoid score	I3955
eggNOG	1	0.900	-	-		E1_KOG2154
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40545
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251577at33208
OrthoFinder	1	1.000	-	-		FOG0004812
OrthoInspector	1	1.000	-	-		oto90053
orthoMCL	1	0.900	-	-		OOG6_102386
Panther	1	1.100	-	-	LDO	PTHR12455
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1838
SonicParanoid	1	1.000	-	-		X3394
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790