DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-alpha and si:ch211-57n23.4

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_009292645.2	Gene:	si:ch211-57n23.4 / 799595	ZFINID:	ZDB-GENE-140106-153	Length:	722	Species:	Danio rerio

Alignment Length:	651	Identity:	137/651 - (21%)
Similarity:	215/651 - (33%)	Gaps:	201/651 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLRNFQ-------------FTSCDRNGKMLIHLLLIVSLLEAIGAFQPEFVESISNVSVAVGRDA 59
            |:|:||             :.:...:..||:.....|.|     |..|:|.....::||..|..|
Zfish    80 LIRSFQKRRDGDATDAGEYYCAAQNHYGMLVSRKARVQL-----ASLPKFHTHPESMSVDDGGVA 139

  Fly    60 TFTCHVRHLGGYRVGWLKADTKAIQAIHENVI--THNPRVTVSHLDQNTWNLHIKAVSEEDRGGY 122
            .|.|.|..:....:.|.|          ::|:  |.:.|.|:..:.    .|.|..|.:.|.|.|
Zfish   140 RFQCQVNGIPEASITWEK----------DHVVLGTSDDRYTLLPMG----ILQITGVKKADAGIY 190

  Fly   123 MCQLN--TDPMKSQIGFLDVV--IP-----PDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVT 178
            .|..:  .:...|....|:|.  :|     |..:|...:..:.|.:  :..|.|.|.|.|.|||:
Zfish   191 RCVASNIANTRYSHEAHLNVTGGVPRTYKEPVILSGPQNLTITVHQ--TAILECIATGNPRPIVS 253

  Fly   179 WRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFH 243
            |.|.||..|.::   |.:.|...    .|.:|.:|....|.|:|.|:.  |.:..:|.:|.   .
Zfish   254 WSRLDGRSIGVE---GIQVLGTG----NLMISDVSLQHSGVYVCAANR--PGTRMRRTALG---R 306

  Fly   244 PVIQVP------NQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMYE 302
            .|:|.|      .|.|..|.|......|..:..|:....|:|        :||......:..:..
Zfish   307 LVVQAPPEFIQWPQSVSKPAGGSAVFTCVAQGVPEPHIIWLK--------NGKILTPGDNVKLTN 363

  Fly   303 TKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRL-----YEIP-GPNRNKNPLNGGGKGGGAGG 361
            ...::.|.:...:|...|:|||:|:.|...:|.||     .|:| .|...|
Zfish   364 NNSTLAVTRITSEDEAIYQCIAENTAGTNQASARLAVSLAKELPDSPQGLK-------------- 414

  Fly   362 SLDADANDILKQKQQVKVTYQP--------------------EDEELQYG-SVEDFEAEGGEGGG 405
                 |..:.|...|:..|..|                    |.:|||.. |...|:.:
Zfish   415 -----ATALSKTSLQLSWTQPPAEVTDGIIGYVLHIRKYGESESKELQEAVSKTTFQHD------ 468

  Fly   406 LTPLSPHVYY----------------------TSGNKPA--------------------THKPGN 428
            ||.|.|...|                      |.|..|:                    .:|||.
Zfish   469 LTNLEPATTYSIYLKAYSPLGASQQSSTVVSTTLGGVPSPPTFFTKAINATAVQVLWELPNKPGK 533

  Fly   429 SGGNQHLHQQHHHHHHHNNNNNNQQHSGGPGGGPTGGDAGSLGG-EMGGITRKPPPYYGGNTE-- 490
            :.|.:..:::..|....           ||...|...:|..:.. :.|.:.......|.||.|
Zfish   534 AEGFRLTYRRVPHGEMQ-----------GPIQLPCHVNAHIISHLDAGAVYEVKLVAYNGNGESD 587

  Fly   491 -----VRGPIDNNEMSSGSGDSRLCR-------------GHHLPILLLPFARLILV----RSWHC 533
                 |....|.....:.:|:...|.             |.|:.:..:.|..|.|:    ||:.|
Zfish   588 CSKKLVSLAEDGTSAKTRAGEEAQCNCRGVEGSVSSIVVGIHIGMACIIFCVLFLMFGYRRSFLC 652

  Fly   534 R 534
            |
Zfish   653 R 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	20/83 (24%)
		Ig	51..131	CDD:299845	20/83 (24%)
		I-set	144..240	CDD:254352	28/95 (29%)
		IGc2	159..228	CDD:197706	22/68 (32%)
		Ig	244..337	CDD:299845	22/98 (22%)
		I-set	244..337	CDD:254352	22/98 (22%)
si:ch211-57n23.4	XP_009292645.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100