DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-alpha and USH2A

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_996816.3	Gene:	USH2A / 7399	HGNCID:	12601	Length:	5202	Species:	Homo sapiens

Alignment Length:	601	Identity:	104/601 - (17%)
Similarity:	168/601 - (27%)	Gaps:	227/601 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 FQPEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQA------------------- 85
            |.|....:::.::....|.|..|..|.:.....|.|.|...:.:|.
Human  2910 FTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLK 2974

  Fly    86 IHENVITHNPRVTVSHLDQNT--W---------------NLHIKAVSEEDRGGYMCQLNTDPMKS 133
            |..:|.:|    .:.||..||  |               .||......|.:|
Human  2975 ILPDVNSH----VIGHLKPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQG------------- 3022

  Fly   134 QIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTL 198
                   ::||         :|::...::||:...:...|..:||      ...:..:|
Human  3023 -------MLPP---------EVVIINSTAVRVIWTSPSNPNGVVT------EYSIYVNN------ 3059

  Fly   199 APSFRGEVLKLSKISRNEMGS---------------------YLCIASNGV-------PPSVSKR 235
                     ||.|...|..||                     |.|:.|||.       .||
Human  3060 ---------KLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPS---- 3111

  Fly   236 ISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSIN-------------YWIKDTGEMIVT 287
                       .:|...:.......:||:.   .||:..|             |....|.::
Human  3112 -----------DIPTPTIRGITSRSLQIDW---VSPRKPNGIILGYDLLWKTWYPCAKTQKL--- 3159

  Fly   288 SGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEIPGP-----NRNK 347
                 ||:.|..:.:.     ||..:.:.:..:.|.  :|..:|..:..||. |.|     ....
Human  3160 -----VQDQSDELCKA-----VRCQKPESICGHICY--SSEAKVCCNGVLYN-PKPGHRCCEEKY 3211

  Fly   348 NPLNGGGKGGGAGGSLDADANDILKQKQQVKVTYQPEDEELQYGSVEDFEAEGGEGGGLTPLSPH 412
            .|......|...||.:           |:.:..:|         ....:.|....|....|...|
Human  3212 IPFVLNSTGVCCGGRI-----------QEAQPNHQ---------CCSGYYARILPGEVCCPDEQH 3256

  Fly   413 --VYYTSGNKPATHKPGNSGGNQ-----HLHQQHHHHHHHNNNNNNQQHSGGPGGGPTGGDAGSL 470
              |....|:......|.::.|||     .||..|           .|:..|..   ....|....
Human  3257 NRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGH-----------GQKCCGRQ---IVSNDLECC 3307

  Fly   471 GGEMGGITRKPPPYYGGNTEVRGPIDNNEMSSGSGDSR--LCRGHHLPILLLPFARLILVRSWHC 533
            |||.|.:..:.|..:....:.....|....|:.||:|:  :.:...:|:              .|
Human  3308 GGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPV--------------KC 3358

  Fly   534 RHTFLMGLSQACLPGL 549
            ..|.|:..||.|..|:
Human  3359 CETELIPKSQKCCNGV 3374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	20/115 (17%)
		Ig	51..131	CDD:299845	20/115 (17%)
		I-set	144..240	CDD:254352	21/123 (17%)
		IGc2	159..228	CDD:197706	16/89 (18%)
		Ig	244..337	CDD:299845	16/105 (15%)
		I-set	244..337	CDD:254352	16/105 (15%)
USH2A	NP_996816.3	LamGL	146..283	CDD:214722
		Laminin_N	291..516	CDD:413488
		EGF_Lam	517..565	CDD:238012
		EGF_Lam	574..639	CDD:238012
		Laminin_EGF	641..691	CDD:395007
		EGF_Lam	694..733	CDD:214543
		Laminin_EGF	747..795	CDD:395007
		EGF_Lam	794..844	CDD:238012
		EGF_Lam	847..897	CDD:214543
		EGF_Lam	900..948	CDD:238012
		EGF_Lam	950..1000	CDD:238012
		EGF_Lam	1001..>1037	CDD:238012
		fn3	1058..1132	CDD:394996
		fn3	1150..1227	CDD:394996
		FN3	1242..1357	CDD:238020
		FN3	1368..1451	CDD:214495
		LamG	1519..1678	CDD:238058
		LamG	1716..1868	CDD:238058
		FN3	1956..2051	CDD:238020
		FN3	2241..2313	CDD:238020
		FN3	2329..2428	CDD:238020
		FN3	2432..2528	CDD:238020
		FN3	2533..2619	CDD:238020
		FN3	2621..2719	CDD:238020
		FN3	2724..2799	CDD:238020
		FN3	2818..2920	CDD:238020	2/9 (22%)
		FN3	2925..3015	CDD:238020	18/93 (19%)
		FN3	3026..>3087	CDD:238020	14/90 (16%)
		FN3	<3449..3494	CDD:238020
		FN3	3503..3586	CDD:238020
		FN3	3590..3676	CDD:238020
		FN3	3680..3767	CDD:238020
		fn3	3777..3856	CDD:394996
		FN3	3866..3960	CDD:238020
		FN3	3964..4057	CDD:238020
		fn3	4161..4247	CDD:394996
		FN3	4268..4351	CDD:238020
		fn3	4357..4428	CDD:394996
		FN3	4444..4516	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4518..4541
		FN3	4529..4627	CDD:238020
		FN3	4636..4730	CDD:238020
		FN3	4826..4927	CDD:238020
		PDZ-binding	5200..5202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900