DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and lrit3a

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio

Alignment Length:	317	Identity:	68/317 - (21%)
Similarity:	102/317 - (32%)	Gaps:	98/317 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSF 202
            ||..:.|..::..|.  :..|.||:|.|.|.|.|:|.|.:.|...||:  |:.:.|..::.....
Zfish   246 LDQCVKPTVMTSATK--ITSPLGSNVLLRCDANGFPTPTLLWTTADGS--VVNNTVVQESPGEGV 306

  Fly   203 RGEVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIH-FHPVIQVPNQLVGAPLGTDVQIECH 266
            |..:|.|..|...:.|.|.|.|.| |..:....|:||:. ..|....|      |:....|.|
Zfish   307 RWSILSLHSIVFKDAGDYRCKAKN-VAGNAEAYITLSVDGVQPTTPFP------PINITKQPE-- 362

  Fly   267 VEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEV 331
                                       .:.:.:...|||.:.                 .||..:
Zfish   363 ---------------------------DQPTTTFTPTKMPLF-----------------TSLSPI 383

  Fly   332 DSSIR--LYEIPGPNRNKNPLNGGG----------------KGGGAGGSLDADANDI-------- 370
            ..:.|  :..:|.....|:|:.|||                ...|.|....:|..||
Zfish   384 TITTRPVMTTMPPLTTRKSPIPGGGVQRSPPAGDKPAKVQQSKNGKGSIKKSDIRDIEVVEETTE 448

  Fly   371 ----------LKQKQQVKVTYQPEDEELQYGSVEDFEAEGGEGGGLTP-LSPHVYYT 416
                      |.....:.|.|.|.|.:   ...|..:.|.|:|..|.. |.|:..||
Zfish   449 TAVLLWSAEGLPSDTPLTVVYFPYDAK---DDKETVDTEVGQGKLLLEYLMPNQVYT 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653
		Ig	51..131	CDD:299845
		I-set	144..240	CDD:254352	29/95 (31%)
		IGc2	159..228	CDD:197706	23/68 (34%)
		Ig	244..337	CDD:299845	11/94 (12%)
		I-set	244..337	CDD:254352	11/94 (12%)
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566
		leucine-rich repeat	83..106	CDD:275378
		LRR_4	107..145	CDD:289563
		leucine-rich repeat	107..130	CDD:275378
		LRR_8	129..>171	CDD:290566
		LRR_4	129..170	CDD:289563
		leucine-rich repeat	131..154	CDD:275378
		leucine-rich repeat	155..168	CDD:275378
		TPKR_C2	199..249	CDD:301599	2/2 (100%)
		Ig	252..343	CDD:299845	29/95 (31%)
		IG_like	261..343	CDD:214653	27/84 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900