DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and OPCML

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001306032.1	Gene:	OPCML / 4978	HGNCID:	8143	Length:	354	Species:	Homo sapiens

Alignment Length:	345	Identity:	100/345 - (28%)
Similarity:	155/345 - (44%)	Gaps:	42/345 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IHLLLIVSLLEAIGAFQPEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHEN 89
            :.||.:|.....:.:....|.:::.||:|..|..||..|.:.. ...||.||...|  |.....:
Human    19 LRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDD-RVTRVAWLNRST--ILYAGND 80

  Fly    90 VITHNPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTD--PMKSQIGFLDVVIPPDFISEDTS 152
            ..:.:|||.:.......:::.|:.|...|.|.|.|.:.||  |..|:: .|.|.:||..:  :.|
Human    81 KWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRV-HLIVQVPPQIM--NIS 142

  Fly   153 SDVIVPEGSSVRLTCRARGYPEPIVTWRR---EDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISR 214
            ||:.|.|||||.|.|.|.|.|||.||||.   ::|...|.:|             |.|::|.|.|
Human   143 SDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSED-------------EYLEISDIKR 194

  Fly   215 NEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIK 279
            ::.|.|.|.|.|.|.....:::.:::::.|.|..... .|..:|....:.|...|.|.:...|.|
Human   195 DQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKN-TGVSVGQKGILSCEASAVPMAEFQWFK 258

  Fly   280 DTGEMIVTSGKYHVQESSQSMYETKMSMIVRKF---QKDDVGSYRCIAKNSLGEVDSSIRLYEI- 340
            :  |..:.:|...::      .|.|..|....|   .:.|.|:|.|:|.|.||..::||.||||
Human   259 E--ETRLATGLDGMR------IENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYEIS 315

  Fly   341 -----PGPNRNKNPLNGGGK 355
                 .||....:.:|...:
Human   316 PSSAVAGPGAVIDGVNSASR 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	22/79 (28%)
		Ig	51..131	CDD:299845	23/81 (28%)
		I-set	144..240	CDD:254352	35/98 (36%)
		IGc2	159..228	CDD:197706	29/71 (41%)
		Ig	244..337	CDD:299845	25/95 (26%)
		I-set	244..337	CDD:254352	25/95 (26%)
OPCML	NP_001306032.1	Ig	44..132	CDD:416386	27/91 (30%)
		Ig strand A'	44..49	CDD:409353	3/4 (75%)
		Ig strand B	51..59	CDD:409353	3/7 (43%)
		CDR1	59..63	CDD:409353	0/4 (0%)
		FR2	64..70	CDD:409353	3/5 (60%)
		Ig strand C	64..70	CDD:409353	3/5 (60%)
		CDR2	71..83	CDD:409353	2/13 (15%)
		Ig strand C'	72..76	CDD:409353	2/5 (40%)
		Ig strand C'	80..83	CDD:409353	0/2 (0%)
		FR3	84..118	CDD:409353	9/33 (27%)
		Ig strand D	87..94	CDD:409353	2/6 (33%)
		Ig strand E	97..103	CDD:409353	0/5 (0%)
		Ig strand F	110..118	CDD:409353	3/7 (43%)
		CDR3	119..123	CDD:409353	2/3 (67%)
		Ig strand G	123..132	CDD:409353	3/9 (33%)
		FR4	125..132	CDD:409353	2/7 (29%)
		Ig_3	135..206	CDD:404760	34/85 (40%)
		Ig strand A	135..138	CDD:409353	2/2 (100%)
		Ig strand A'	144..148	CDD:409353	1/3 (33%)
		Ig strand B	151..160	CDD:409353	5/8 (63%)
		Ig strand C	165..170	CDD:409353	3/4 (75%)
		Ig strand C'	171..174	CDD:409353	0/2 (0%)
		Ig strand F	198..206	CDD:409353	4/7 (57%)
		Ig	224..312	CDD:416386	25/96 (26%)
		putative Ig strand A	224..230	CDD:409353	2/5 (40%)
		Ig strand B	240..244	CDD:409353	0/3 (0%)
		Ig strand C	253..257	CDD:409353	0/3 (0%)
		Ig strand E	279..283	CDD:409353	0/3 (0%)
		Ig strand F	293..298	CDD:409353	2/4 (50%)
		Ig strand G	306..309	CDD:409353	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.900