DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and NCAM2

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	344	Identity:	81/344 - (23%)
Similarity:	124/344 - (36%)	Gaps:	77/344 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 FVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNTW- 107
            |.|.:|......|.||...|.|.......|.||               .||..||.  :..|.:
Human   142 FREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWL---------------YHNEEVTT--ISDNRFA 189

  Fly   108 -----NLHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVV----IPPDFISEDTSSDVIVPEGSSV 163
                 ||.|..:::.|.|.|.|:...: .:.:|.|.|::    :||.......|.:.....|..:
Human   190 MLANNNLQILNINKSDEGIYRCEGRVE-ARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEM 253

  Fly   164 RLTCRARGYPEPIVTWRR-----EDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCI 223
            ..:|||.|.|||.::|.|     |:..:.:||   |:.|        .|.:..|..::.|.|:|.
Human   254 TFSCRASGSPEPAISWFRNGKLIEENEKYILK---GSNT--------ELTVRNIINSDGGPYVCR 307

  Fly   224 ASNGVPPSVSKRISLSIHFHP-VIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVT 287
            |:|..... .|:..|.:...| :||:.|:....  ...|.:.|..|..|.....|.:.......|
Human   308 ATNKAGED-EKQAFLQVFVQPHIIQLKNETTYE--NGQVTLVCDAEGEPIPEITWKRAVDGFTFT 369

  Fly   288 SGKYHVQESSQSMYETK-----MSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRL---------- 337
            .|    .:|.....|.|     .|:.::..:..|.|.|.|.|.:.:|....|:.|
Human   370 EG----DKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFIS 430

  Fly   338 -----YEIPGPNRNKNPLN 351
                 |...|     ||:|
Human   431 NQTIYYSWEG-----NPIN 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	21/85 (25%)
		Ig	51..131	CDD:299845	20/85 (24%)
		I-set	144..240	CDD:254352	26/100 (26%)
		IGc2	159..228	CDD:197706	22/73 (30%)
		Ig	244..337	CDD:299845	22/98 (22%)
		I-set	244..337	CDD:254352	22/98 (22%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274
		I-set	47..136	CDD:254352
		I-set	142..218	CDD:254352	23/93 (25%)
		IGc2	153..214	CDD:197706	20/77 (26%)
		Ig	233..326	CDD:299845	27/104 (26%)
		I-set	240..323	CDD:254352	25/94 (27%)
		Ig5_NCAM-2	325..422	CDD:143278	23/102 (23%)
		IG_like	333..420	CDD:214653	19/92 (21%)
		IG_like	438..515	CDD:214653	4/12 (33%)
		IGc2	439..507	CDD:197706	4/11 (36%)
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910