DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and opcml

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001005580.1	Gene:	opcml / 449538	ZFINID:	ZDB-GENE-040927-3	Length:	342	Species:	Danio rerio

Alignment Length:	305	Identity:	90/305 - (29%)
Similarity:	144/305 - (47%)	Gaps:	46/305 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 NVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVITHN------PRVTVSHLDQNTWN 108
            |::|..|..|...|.:.:... ||.||...|        .:.|.|      |||.:.:...|.::
Zfish    41 NITVRQGDSAVLKCSMDNKVS-RVAWLNRTT--------ILFTGNEKWSLDPRVVLLNTAVNEYS 96

  Fly   109 LHIKAVSEEDRGGYMCQL--NTDPMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARG 171
            :.|..|:..|.|.|:|.:  |..|..::: .|.|.:|...:  :.|:||.|.|||:|.|.|.|.|
Zfish    97 IKILNVNLYDEGPYVCSILTNKKPESTKV-HLIVQVPARIV--NVSTDVSVNEGSNVSLMCLAIG 158

  Fly   172 YPEPIVTW--RREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSK 234
            .|||.:.|  |...||.||.:             ||.::::.|:::..|||.||.||.:.|...:
Zfish   159 RPEPSILWKFRSSKGNRIVTE-------------GEYVEMTGITKDMSGSYDCITSNDISPPDVR 210

  Fly   235 RISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQS 299
            .:.:::::.|||..... .|..:|....:.|...|.|.:...|.|  ||..:.:|...|:..::.
Zfish   211 TVQVTVNYPPVISRARS-TGTAVGQKGVLWCEASAVPLADFQWFK--GERRILNGFNGVKIENKG 272

  Fly   300 MYETKMSMIV-RKFQKDDVGSYRCIAKNSLGEVDSSIRLYEIPGP 343
                |.||:. ....::|.|:|.|:|.|:||..::||.||   ||
Zfish   273 ----KQSMLTFFNVSEEDYGNYTCVAINTLGITNASIILY---GP 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	23/86 (27%)
		Ig	51..131	CDD:299845	22/87 (25%)
		I-set	144..240	CDD:254352	32/97 (33%)
		IGc2	159..228	CDD:197706	27/70 (39%)
		Ig	244..337	CDD:299845	27/93 (29%)
		I-set	244..337	CDD:254352	27/93 (29%)
opcml	NP_001005580.1	Ig	41..129	CDD:299845	25/97 (26%)
		IG_like	41..129	CDD:214653	25/97 (26%)
		IG_like	139..216	CDD:214653	32/89 (36%)
		IGc2	146..202	CDD:197706	25/68 (37%)
		I-set	219..307	CDD:254352	27/94 (29%)
		ig	223..307	CDD:278476	24/90 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.900