DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and negr1

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	357	Identity:	101/357 - (28%)
Similarity:	159/357 - (44%)	Gaps:	63/357 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IVSLLEAIGAFQP---------EFVESISNVSVAVGRDATFTCHVRHLGGYRVG-WLKADTKAIQ 84
            :.:::.::..|.|         ::..|..:|....|..|...|::  |.|...| ||  :..:|.
Zfish    17 LTAIILSLCCFLPSCLPAGQTVDYTTSSESVVSRQGDTALLRCYL--LDGISKGAWL--NRSSII 77

  Fly    85 AIHENVITHNPRVT-VSHL-DQNTWNLHIKAVSEEDRGGYMCQL----NTDPMKSQIGFLDVVIP 143
            ....:..:.:|||: ||:: |::.::|.|:.|...|.|.|.|.:    |..|...|   |.|.:|
Zfish    78 YAGNDKWSGDPRVSIVSNVGDKHEYSLQIQKVDVTDEGVYTCSIQSERNLHPKLIQ---LIVKVP 139

  Fly   144 PDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFR----G 204
            |...  |.|||:.|.|||:|.|.|.|.|.|||.::||.                ::||.|    |
Zfish   140 PKIY--DISSDITVNEGSNVSLICAASGKPEPKISWRH----------------ISPSARKYESG 186

  Fly   205 EVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEA 269
            |.|.::.|||::.|.|.|.|.|.:....:|.:.::::|.|.|. ..:..|...|....:.|...|
Zfish   187 EYLNITGISRDQAGDYECGAENDIASPDTKTVRVTVNFPPAIH-EMKSHGVRPGQVALLRCEAAA 250

  Fly   270 SPKSINYWIKDTGEMIVTSGKYHV--QESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVD 332
            .|..:..|.|  ||..:..|:..|  ..||:|:      :.|:...:|..|:|.|:|.|.||..:
Zfish   251 VPSPVFEWYK--GEKRINMGQGIVINNLSSRSV------LTVKNMTQDRYGNYTCVAVNRLGTAN 307

  Fly   333 SSIRLYEIPGPNRN-------KNPLNGGGKGG 357
            :|:.|..|..|...       .||...|..||
Zfish   308 ASVPLNPIIEPTTTSAVSSPASNPAMYGSTGG 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	24/86 (28%)
		Ig	51..131	CDD:299845	24/86 (28%)
		I-set	144..240	CDD:254352	34/99 (34%)
		IGc2	159..228	CDD:197706	27/72 (38%)
		Ig	244..337	CDD:299845	26/94 (28%)
		I-set	244..337	CDD:254352	26/94 (28%)
negr1	XP_009300786.1	Ig	42..121	CDD:299845	24/82 (29%)
		IG_like	44..136	CDD:214653	27/98 (28%)
		I-set	140..222	CDD:254352	34/99 (34%)
		IGc2	153..208	CDD:197706	26/70 (37%)
		IG_like	236..312	CDD:214653	23/83 (28%)
		IGc2	238..304	CDD:197706	20/73 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820