DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and LSAMP

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	367	Identity:	103/367 - (28%)
Similarity:	160/367 - (43%)	Gaps:	54/367 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DRNGKMLIHLLLIVSLLEAIGAFQPEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKA 82
            ||....|:.|.|:..|...:.....:|.....|::|..|..|...|.|..... :|.||.. :..
Human     8 DRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNS-KVAWLNR-SGI 70

  Fly    83 IQAIHENVITHNPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQLNT--DPMKSQIGFLDVVIPPD 145
            |.|.|:. .:.:|||.:.......::|.|:.|...|.|.|.|.:.|  :|..||: :|.|.:||.
Human    71 IFAGHDK-WSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQV-YLIVQVPPK 133

  Fly   146 FISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPS---FRG--E 205
            .  .:.||||.|.|||:|.|.|.|.|.|||::|||.                |.|:   |.|  |
Human   134 I--SNISSDVTVNEGSNVTLVCMANGRPEPVITWRH----------------LTPTGREFEGEEE 180

  Fly   206 VLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEAS 270
            .|::..|:|.:.|.|.|.|:|.|..:..|::.:::::.|.| ..::...|..|....::|...|.
Human   181 YLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTI-TESKSNEATTGRQASLKCEASAV 244

  Fly   271 PKSINYWIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSI 335
            |.....|.:|...:...:|........||      |:.|....::..|:|.|:|.|.||..::|:
Human   245 PAPDFEWYRDDTRINSANGLEIKSTEGQS------SLTVTNVTEEHYGNYTCVAANKLGVTNASL 303

  Fly   336 RLYE-----IPGP---------NRNKNPLNGGGKGGGAGGSL 363
            .|::     ||.|         .:.|.|    |...|..||:
Human   304 VLFKRVLPTIPHPIQEIGTTVHFKQKGP----GSVRGINGSI 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	23/81 (28%)
		Ig	51..131	CDD:299845	22/81 (27%)
		I-set	144..240	CDD:254352	35/100 (35%)
		IGc2	159..228	CDD:197706	27/73 (37%)
		Ig	244..337	CDD:299845	22/92 (24%)
		I-set	244..337	CDD:254352	22/92 (24%)
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	27/93 (29%)
		Ig	132..215	CDD:386229	35/100 (35%)
		Ig_3	219..294	CDD:372822	18/81 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.900