DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	193/382 - (50%)
Similarity:	264/382 - (69%)	Gaps:	33/382 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KMLIHLLL-------IVSLLEAIGAFQPEFVESISNVSVAVGRDATFTCHVRHLGGYR------- 72
            ::|:.|||       :.:.:.::|||:|:||..:.||::|.||||||||.|.:|||:|
  Fly    71 QLLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSS 135

  Fly    73 ----VGWLKADTKAIQAIHENVITHNPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTDPMKS 133
                |.|:|||.|||.||||:|||:|.|::|.|.|.|||.|:|:.|..||.|.||||:||||||.
  Fly   136 APAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKM 200

  Fly   134 QIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTL 198
            |...|:||||||.|:|:||.|::||||.|.:|.|||||:|:|.:|||||||.||:.::....||.
  Fly   201 QTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTK 265

  Fly   199 APSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQI 263
            |.|..||:|.||||:|:|||:|:|||||||||:||||:.|.:||||::||||||||||:.|||.:
  Fly   266 AQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTL 330

  Fly   264 ECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSL 328
            .|:||||||:||||.::.||||:...:|.:.|...:||..:|.:.:::.|..|.|.|:||:|||:
  Fly   331 ICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSI 395

  Fly   329 GEVDSSIRLYEIPGPNRNKNPLNGGGKGGGAGGSLDADANDILKQKQQVKVTYQPED 385
            |:.:.:|||||:..|  .|..|.            |.|.|::.|.:...|.| :.||
  Fly   396 GDTEGTIRLYEMERP--GKKILR------------DDDLNEVSKNEVVQKDT-RSED 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	50/90 (56%)
		Ig	51..131	CDD:299845	51/90 (57%)
		I-set	144..240	CDD:254352	59/95 (62%)
		IGc2	159..228	CDD:197706	41/68 (60%)
		Ig	244..337	CDD:299845	45/92 (49%)
		I-set	244..337	CDD:254352	45/92 (49%)
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	61/110 (55%)
		ig	102..195	CDD:278476	49/92 (53%)
		IG_like	219..307	CDD:214653	54/87 (62%)
		Ig	221..307	CDD:299845	53/85 (62%)
		Ig	311..404	CDD:299845	45/92 (49%)
		IG_like	327..405	CDD:214653	34/77 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11903
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122242at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	8	7.970