DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-alpha and Sdk1

DIOPT Version :9

Sequence 1:NP_001259218.1 Gene:DIP-alpha / 31322 FlyBaseID:FBgn0052791 Length:554 Species:Drosophila melanogaster
Sequence 2:NP_808547.3 Gene:Sdk1 / 330222 MGIID:2444413 Length:2193 Species:Mus musculus


Alignment Length:262 Identity:70/262 - (26%)
Similarity:117/262 - (44%) Gaps:29/262 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 NPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTDPMKSQI-GFLDVV-IPPDFISEDTSSDVI 156
            |||..|    ..:..|||:.:|.||.|.:.|..:.:..:.|. .:|||. |.|.|.....  |..
Mouse   414 NPRYKV----LPSGGLHIQKLSPEDSGIFQCFASNEGGEVQTHTYLDV
TNIAPAFTQRPV--DTT 472

  Fly   157 VPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSF---RGEVLKLSKISRNEMG 218
            |.:|.:..|.|...|.|:|.:||:|  ||.|:...:|    ..|.|   ....|:::.:...:.|
Mouse   473 VTDGMTAVLRCEVSGAPKPAITWKR--GNHILASGSV----RIPRFMLLESGGLRIAPVFIQDAG 531

  Fly   219 SYLCIASNGVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPK-SINY-WIKDT 281
            :|.|.|:| ...||:....|::.....|..|.:......||...:.|.....|: |:.| |.|| 
Mouse   532 NYTCYAAN-TEASVNASAMLTV
WNRTSIVHPPEDRVVIKGTTATLCCGATHDPRTSLRYVWKKD- 594

  Fly   282 GEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRC--IAKNSLGEVDSSIRLYEIPGPN 344
             .:::|:     ..||:.:.|...|:::.:....|:|.|.|  |::.......:.:.:.|:|.|.
Mouse   595 -NVVITA-----SSSSRIVVEKDGSLVISQTWSGDIGDYTCEIISEGGSDSRTARLEVIELPHPP 653

  Fly   345 RN 346
            :|
Mouse   654 QN 655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-alphaNP_001259218.1 IG_like 49..129 CDD:214653 12/34 (35%)
Ig 51..131 CDD:299845 12/36 (33%)
I-set 144..240 CDD:254352 28/98 (29%)
IGc2 159..228 CDD:197706 21/71 (30%)
Ig 244..337 CDD:299845 21/96 (22%)
I-set 244..337 CDD:254352 21/96 (22%)
Sdk1NP_808547.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56
Ig_2 94..169 CDD:290606
IG_like 100..169 CDD:214653
IG_like 183..263 CDD:214653
Ig 197..247 CDD:299845
IG_like 281..357 CDD:214653
IGc2 294..347 CDD:197706
I-set 368..457 CDD:254352 14/46 (30%)
Ig 388..454 CDD:143165 13/43 (30%)
I-set 462..552 CDD:254352 28/98 (29%)
Ig 476..552 CDD:299845 24/82 (29%)
I-set 557..646 CDD:254352 21/95 (22%)
Ig 562..646 CDD:299845 19/90 (21%)
FN3 650..741 CDD:238020 3/6 (50%)
fn3 753..839 CDD:278470
FN3 854..949 CDD:238020
FN3 954..1036 CDD:238020
FN3 1052..1148 CDD:238020
FN3 1158..1253 CDD:238020
FN3 1261..1349 CDD:238020
FN3 1360..1453 CDD:238020
FN3 1459..1554 CDD:238020
FN3 1562..1676 CDD:238020
FN3 1686..1779 CDD:238020
FN3 1784..1865 CDD:238020
FN3 1885..1978 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2057..2080
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2187..2193
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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