DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and Prtg

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001032740.2	Gene:	Prtg / 315806	RGDID:	1307157	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	356	Identity:	88/356 - (24%)
Similarity:	143/356 - (40%)	Gaps:	57/356 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FQFTSCDRNGKML---IHLLLIVSLLEAIGAFQPEFVESISNVSVAVGRDATFTCHVRHLGGYRV 73
            :|..:.::.|.:|   .||     .|..|.||:   |..:| ..|..|..|.|:|.:.......:
  Rat   105 YQCLAVNKYGAILSQKAHL-----TLSTISAFE---VHPVS-TEVPEGGVARFSCKISSTPPAVI 160

  Fly    74 GWLKADTKAIQAIHENVITHNPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTDPMKSQIGFL 138
            .| :.:..|:....::.:|..|          :..|.|.....||.|.|.|...|...|.:....
  Rat   161 TW-EFNRTALPMTMDSRVTALP----------SGVLQIYDAGPEDAGKYRCVAATHAHKRKSMEA 214

  Fly   139 DVVIPPDFISEDTSS-----------DVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDN 192
            .:.|.|   :.:|.|           :|......:|.|.|.|.|||:||::|.|.|...|   |.
  Rat   215 SLTIVP---ANETRSFYMPTIIASPQNVTASLHQTVVLECMATGYPKPIISWSRLDHKSI---DV 273

  Fly   193 VGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASN-GVPPSVSKRISLSIHFHP-VIQVPNQLVGA 255
            ..|:.|.   .|.:: :|.:.....|.|:|.|:. |.........:|::...| .::.|..|...
  Rat   274 FNTRVLG---NGNLI-ISDVKLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRP 334

  Fly   256 PLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSY 320
            ..|| .:..|..|..|.....|:|: |..|.::|:.       .||.:|  :::.:...:|...|
  Rat   335 RAGT-ARFVCQAEGIPSPKMSWLKN-GRRIHSNGRI-------KMYNSK--LVINQIIPEDDAIY 388

  Fly   321 RCIAKNSLGEVDSSIRLYEIPGPNRNKNPLN 351
            :|:|:||.|.|.|..||..:...:|...|.|
  Rat   389 QCMAENSQGSVLSRARLTVVMSEDRPSAPYN 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	17/79 (22%)
		Ig	51..131	CDD:299845	17/79 (22%)
		I-set	144..240	CDD:254352	28/107 (26%)
		IGc2	159..228	CDD:197706	22/69 (32%)
		Ig	244..337	CDD:299845	25/93 (27%)
		I-set	244..337	CDD:254352	25/93 (27%)
Prtg	NP_001032740.2	Ig	32..124	CDD:416386	5/23 (22%)
		Ig strand A	32..35	CDD:409353
		Ig strand A'	38..44	CDD:409353
		Ig strand B	48..58	CDD:409353
		Ig strand C	62..68	CDD:409353
		Ig strand C'	70..73	CDD:409353
		Ig strand D	78..83	CDD:409353
		Ig strand E	85..91	CDD:409353
		Ig strand F	103..110	CDD:409353	1/4 (25%)
		Ig strand G	114..124	CDD:409353	4/14 (29%)
		Ig	131..218	CDD:416386	21/101 (21%)
		Ig strand B	146..150	CDD:409353	2/3 (67%)
		Ig strand C	159..163	CDD:409353	1/4 (25%)
		Ig strand E	183..187	CDD:409353	1/3 (33%)
		Ig strand F	197..202	CDD:409353	2/4 (50%)
		Ig strand G	211..214	CDD:409353	0/2 (0%)
		Ig_3	230..302	CDD:404760	22/78 (28%)
		Ig strand B	247..251	CDD:409353	2/3 (67%)
		Ig strand C	260..264	CDD:409353	1/3 (33%)
		Ig strand E	282..286	CDD:409353	1/4 (25%)
		Ig strand F	296..301	CDD:409353	2/4 (50%)
		I-set	322..407	CDD:400151	27/95 (28%)
		Ig strand C	352..357	CDD:409353	1/4 (25%)
		Ig strand C'	359..362	CDD:409353	1/2 (50%)
		Ig strand D	367..371	CDD:409353	0/10 (0%)
		Ig strand E	373..378	CDD:409353	1/6 (17%)
		Ig strand F	387..394	CDD:409353	3/6 (50%)
		Ig strand G	398..407	CDD:409353	4/8 (50%)
		FN3	414..507	CDD:238020	2/6 (33%)
		FN3	512..605	CDD:238020
		fn3	619..694	CDD:394996
		FN3	721..809	CDD:238020
		FN3	816..906	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	974..1018
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100