DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-alpha and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	94/367 - (25%)
Similarity:	143/367 - (38%)	Gaps:	92/367 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LIVSLLEAIGAF---------QPEFVESISNVSVAVGRDATFTCHVRH-LGG----YRVGWLKAD 79
            ||.|::...|..         :|||      |:...|......|.|.| :.|    |.|.|.|..
  Rat     8 LIASVISTRGLVAQVAHGLREEPEF------VTARAGEGVVLRCDVIHPVTGQPPPYVVEWFKFG 66

  Fly    80 TKAIQAIHENVITHNPRVTVSHLDQNTWNLHIKA------VSEEDRGGYMC-------QLNTDPM 131
            ...  .|......:.|.|...:..:.  :||.||      |..||:|.|.|       |.:|...
  Rat    67 VPI--PIFIKFGYYPPHVDPEYAGRA--SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHN 127

  Fly   132 KSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTK 196
            .|.: .|.:..||.| :|.....:...||.|:.:||.|.|.|:|||||.:|           ||
  Rat   128 GSWV-HLTINAPPTF-TETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKE-----------GT- 178

  Fly   197 TLAPSFRGEV----LKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIH-FHPVIQVPNQLVGAP 256
            .|:.|.:.:|    |.::.:||.:.|:|.|.|.     |:...   ::| .|.::|.|..:|..|
  Rat   179 LLSASGKYQVSDGSLTVTSVSREDRGAYTCRAY-----SIQGE---AVHTTHLLVQGPPFIVSPP 235

  Fly   257 ------LGTDVQIECHVEASPKSINY-WIKDTGEMIVTSGKYHVQESSQSMYETKM--------S 306
                  :..|..:.|..||.|.::.| |             |...|:.....:.|:        :
  Rat   236 ENITVNISQDALLTCRAEAYPGNLTYTW-------------YWQDENVYFQNDLKLRVRILIDGT 287

  Fly   307 MIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEIPGPNRNKN 348
            :|:.:.:.:|.|.|.|:..||||...|:.....:..|.|..|
  Rat   288 LIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVLN 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	24/97 (25%)
		Ig	51..131	CDD:299845	25/97 (26%)
		I-set	144..240	CDD:254352	30/99 (30%)
		IGc2	159..228	CDD:197706	26/72 (36%)
		Ig	244..337	CDD:299845	24/107 (22%)
		I-set	244..337	CDD:254352	24/107 (22%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273	21/77 (27%)
		I-set	139..225	CDD:369462	32/106 (30%)
		Ig	229..321	CDD:386229	22/104 (21%)
		Ig	<353..414	CDD:386229
		Ig	438..502	CDD:319273
		FN3	510..605	CDD:238020
		FN3	621..703	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910