DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-alpha and kirre

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	138/762 - (18%)
Similarity:	209/762 - (27%)	Gaps:	333/762 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VSAKRLLR--------NFQFTSCD---------RNGKMLIHLLLIVSLLEAIGAFQPEFVESISN 50
            ::|:.:|:        |..|| |.         |:.|:|:.:           .:.|:.:.|:..
  Fly   247 ITARSILKLAPKKEHHNTTFT-CQAQNTADRTYRSAKLLLEV-----------KYAPKVIVSVVG 299

  Fly    51 VSVAVGR-----DATFTCHV---RHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNTW 107
            .::|.|:     :...:|..   .|...||  |...|..........:|.||
  Fly   300 GALAGGKIPEGAEVILSCQADANPHELSYR--WFINDELMTGDFTTKMIIHN------------- 349

  Fly   108 NLHIKAVSEEDRGGYM-CQ-LNTDPMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRAR 170
                  ||.:.....: |: :|......|...||:...|.|.....|.:..:  |::|.:.|...
  Fly   350 ------VSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADL--GATVSMRCDVA 406

  Fly   171 GYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIA-SNGVPPSVSK 234
            |.|||.:.|..|:.:::|   .|..:          ||| |:|....|.|.|.| .||. |.:..
  Fly   407 GNPEPEIEWISENSDQVV---GVAAE----------LKL-KVSSETAGRYFCKAVVNGF-PEIGA 456

  Fly   235 RISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSG---------K 290
            ..:|.:...|:|.......|. :|..|:|:|...:.||:.:......|::|..|.         :
  Fly   457 EATLYVKRAPIITSHKVQFGG-VGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEE 520

  Fly   291 YHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLG-------------------------- 329
            :|:.|.      .:.::|:|..:....|.|.|...||.|
  Fly   521 HHLPEG------VRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMF 579

  Fly   330 -----------------------------------------EVDSSIRL---------------- 337
                                                     |:.|.:|.
  Fly   580 CVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLA 644

  Fly   338 ----------------------------------------------------------------- 337

  Fly   645 INLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQETAYKGSPQAN 709

  Fly   338 -----------YEIPG--------------------------PNRNKNPLNGGGKGGGAGGSLDA 365
                       |..||                          |:.....:||||.|.|.|.||..
  Fly   710 GYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSATLPHSAAATVNGGGAGNGGGASLPR 774

  Fly   366 DANDILKQKQQVK-VTYQPEDEELQYGSVEDFEAEGG------EGGGLTPLSPHVYYTSGNKPAT 423
            :....::|.||.. ...||   .||.|....|.|..|      ....|.||.|         |:|
  Fly   775 NQRHEIQQSQQSNGFLGQP---LLQNGIDSRFSAIYGNPYLRTNSSLLPPLPP---------PST 827

  Fly   424 HKPGNSGGNQHLHQQHHHHHHHNNNN---------------NNQQHSGGPGGG--PTGGD----- 466
            ..|..:......|...|.|.||.|..               .|...:||.|||  |:||.
  Fly   828 ANPAATPAPPPYHAARHGHAHHANGGLKHFVGGAVITTSPVGNVNINGGGGGGSTPSGGGGVGVG 892

  Fly   467 ---AGSLGGEMGGITRKPPPYYGGNTEVRGPIDNNEMSSGSGDSRLC 510
               .||:.|....:|.      ..||....|:    ...|.|:|..|
  Fly   893 VAAGGSVSGSSSNLTA------SSNTLAATPL----AGGGVGNSGQC 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	15/89 (17%)
		Ig	51..131	CDD:299845	15/89 (17%)
		I-set	144..240	CDD:254352	27/96 (28%)
		IGc2	159..228	CDD:197706	21/69 (30%)
		Ig	244..337	CDD:299845	24/168 (14%)
		I-set	244..337	CDD:254352	24/168 (14%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845
		IG_like	88..182	CDD:214653
		C2-set_2	189..279	CDD:285423	6/32 (19%)
		Ig_2	307..379	CDD:290606	16/92 (17%)
		I-set	382..462	CDD:254352	27/96 (28%)
		IGc2	396..446	CDD:197706	19/63 (30%)
		Ig	466..561	CDD:299845	22/101 (22%)
		IG_like	478..561	CDD:214653	19/88 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810