DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-alpha and Kirrel1

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_006232737.1	Gene:	Kirrel1 / 310695	RGDID:	727883	Length:	805	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	87/352 - (24%)
Similarity:	139/352 - (39%)	Gaps:	68/352 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MLIHLLLIVSLLEAIGAFQPEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAI---Q 84
            :::..|:.|:|..|:...|..|.:..::.:|..|..|...|.:.:..|. |.|.| |..|:   |
  Rat    34 LVVAYLIFVTLALALPGTQTRFSQEPADQTVVAGHRAVLPCVLLNYSGI-VQWTK-DGLALGMGQ 96

  Fly    85 AIHENVITHNPRV-TVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVVIPPDFIS 148
            .:..     .||. .|...|...:||.|......|...|.||.....::|:...|.|:|||
  Rat    97 GLKA-----WPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPP---- 152

  Fly   149 EDTSSD----VIVPEGSSVRLTCRA-RGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLK 208
            |||..|    :::..|:...||||| ...|...:.|.| ||.:   ::...|.|       |:||
  Rat   153 EDTRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFR-DGTQ---QEGAVTST-------ELLK 206

  Fly   209 LSK----ISR-------NEMGS-YLCIASN-GVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTD 260
            ..|    ||:       .::|. :.|.:.| .:|......|.|.:|..|.:.:..:......|..
  Rat   207 DGKRETTISQLLIQPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGER 271

  Fly   261 VQIECHVEASPKSINY-WIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIA 324
            |...|...|:|:.:.| |.|         |.:.::::.:|.|||.:..   .|..:.|.   |..
  Rat   272 VIFTCQATANPEILGYRWAK---------GGFLIEDAHESRYETNVDY---SFFTEPVS---CEV 321

  Fly   325 KNSLGEVDSSI--------RLYEIPGP 343
            .|.:|..:.|.        |:...|.|
  Rat   322 YNKVGSTNVSTLVNVHFAPRIVVYPKP 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	22/83 (27%)
		Ig	51..131	CDD:299845	22/83 (27%)
		I-set	144..240	CDD:254352	30/113 (27%)
		IGc2	159..228	CDD:197706	22/82 (27%)
		Ig	244..337	CDD:299845	20/101 (20%)
		I-set	244..337	CDD:254352	20/101 (20%)
Kirrel1	XP_006232737.1	I-set	54..148	CDD:254352	25/100 (25%)
		Ig	57..148	CDD:299845	24/97 (25%)
		Ig2_KIRREL3-like	170..251	CDD:143236	24/91 (26%)
		I-set	255..336	CDD:254352	20/95 (21%)
		Ig_2	259..337	CDD:290606	19/92 (21%)
		Ig_2	340..437	CDD:290606	3/9 (33%)
		IG_like	346..437	CDD:214653	2/3 (67%)
		Ig5_KIRREL3	439..536	CDD:143306
		IG_like	451..536	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900