DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-alpha and Igsf9

DIOPT Version :9

Sequence 1:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	330	Identity:	89/330 - (26%)
Similarity:	138/330 - (41%)	Gaps:	62/330 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LLIVSLLEAIGA---FQPEFVESISNVSVAVGRDATFTCHVRHLGG----YRVGWLKADTKAIQA 85
            |.|:||:.:.||   .:||.|..:..    .|..|...|.:....|    :.:.||:..  .:..
  Rat     7 LTILSLILSQGADGRRKPEVVSVVGR----AGESAVLGCDLLPPAGRPPLHVIEWLRFG--FLLP 65

  Fly    86 IHENVITHNPRVTVSHLD----QNTWNLHIKAVSEEDRGGYMCQ-LNTDPMKSQIGF-------L 138
            |......::||:...::.    |...:|.|:.:..||:|.|.|: |..|....:..|       |
  Rat    66 IFIQFGLYSPRIDPDYVGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHL 130

  Fly   139 DVVIPPDFISEDTSSDVI-VPEGSSVRLTCRARGYPEPIVTW--RREDGNEIVLKDNVGTKTLAP 200
            .|..||.|  ::|...|: |.|..:|.|.|.|.|.|:|.|||  |.:|         :|......
  Rat   131 TVNSPPQF--QETPPLVLEVKELEAVTLRCVALGSPQPYVTWKFRGQD---------LGKGQGQV 184

  Fly   201 SFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVP--NQLVGAPLGTDVQI 263
            ..|...|.:.::.|...|.|.|.||: ...||:....|.:...|||.||  |..|.|  ..||.:
  Rat   185 QVRNGTLWIRRVERGSAGDYTCQASS-TEGSVTHTTQLLVLGPPVIVVPPNNNTVNA--SQDVSL 246

  Fly   264 ECHVEASPKSINY-WIKDTGEMIVTSGKYHVQESSQSMYETKMSMIV------RKFQKDDVGSYR 321
            .|..||.|.::.| |.:|...:      :|:     |..::::.::|      :..|.||.|.|.
  Rat   247 ACRAEAYPANLTYSWFQDRINV------FHI-----SRLQSRVRILVDGSLWLQATQPDDAGHYT 300

  Fly   322 CIAKN 326
            |:..|
  Rat   301 CVPSN 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	18/88 (20%)
		Ig	51..131	CDD:299845	19/88 (22%)
		I-set	144..240	CDD:254352	30/98 (31%)
		IGc2	159..228	CDD:197706	22/70 (31%)
		Ig	244..337	CDD:299845	27/92 (29%)
		I-set	244..337	CDD:254352	27/92 (29%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	17/87 (20%)
		Ig strand A	136..139	CDD:409353	2/4 (50%)
		IG_like	143..223	CDD:214653	27/89 (30%)
		Ig strand A'	145..148	CDD:409353	1/2 (50%)
		Ig strand B	154..161	CDD:409353	3/6 (50%)
		Ig strand C	167..172	CDD:409353	3/4 (75%)
		Ig strand C'	175..177	CDD:409353	1/10 (10%)
		Ig strand D	183..187	CDD:409353	0/3 (0%)
		Ig strand E	189..193	CDD:409353	1/3 (33%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	3/9 (33%)
		Ig_3	226..305	CDD:404760	26/91 (29%)
		putative Ig strand A	226..230	CDD:409353	2/3 (67%)
		putative Ig strand A'	235..239	CDD:409353	1/3 (33%)
		putative Ig strand B	241..251	CDD:409353	3/9 (33%)
		putative Ig strand C'	267..270	CDD:409353	0/8 (0%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	0/5 (0%)
		putative Ig strand F	297..305	CDD:409353	3/7 (43%)
		putative Ig strand G	310..319	CDD:409353
		Ig	322..407	CDD:416386
		Ig strand A'	324..328	CDD:409353
		Ig strand B	333..347	CDD:409353
		Ig strand C	353..359	CDD:409353
		Ig strand C'	362..364	CDD:409353
		Ig strand D	371..374	CDD:409353
		Ig strand E	378..382	CDD:409353
		Ig strand F	391..399	CDD:409353
		Ig	418..503	CDD:416386
		Ig strand A	418..421	CDD:409353
		Ig strand A'	427..430	CDD:409353
		Ig strand B	436..443	CDD:409353
		Ig strand C	449..454	CDD:409353
		Ig strand C'	457..459	CDD:409353
		Ig strand D	462..466	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	482..490	CDD:409353
		Ig strand G	493..503	CDD:409353
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000